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Strategies to access biosynthetic novelty in bacterial genomes for drug discovery

Nature reviews. Drug discovery, 2022-05, Vol.21 (5), p.359-378

2022

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A roadmap for metagenomic enzyme discovery

Natural product reports, 2021-11, Vol.38 (11), p.1994-223

2021

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Biosynthesis of polyketides by trans-AT polyketide synthases

Natural product reports, 2016-02, Vol.33 (2), p.231-316

2016

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A Polyketide Synthase-Peptide Synthetase Gene Cluster from an Uncultured Bacterial Symbiont of Paederus Beetles

Proceedings of the National Academy of Sciences - PNAS, 2002-10, Vol.99 (22), p.14002-14007

Piel, Jörn

2002

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In Vivo Production of Diverse β‐Amino Acid‐Containing Proteins

Angewandte Chemie (International ed.), 2022-07, Vol.61 (29), p.e202202695-n/a

International ed. in English, 2022

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Genomic insights into the marine sponge microbiome

Nature reviews. Microbiology, 2012-09, Vol.10 (9), p.641-654

2012

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Aranazoles: Extensively Chlorinated Nonribosomal Peptide–Polyketide Hybrids from the Cyanobacterium Fischerella sp. PCC 9339

Organic letters, 2018-09, Vol.20 (17), p.5238-5241

2018

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Approaches to Capturing and Designing Biologically Active Small Molecules Produced by Uncultured Microbes

Annual review of microbiology, 2011-01, Vol.65 (1), p.431-453

Piel, Jörn

2011

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Comparative Genomics Underlines Multiple Roles of Profftella, an Obligate Symbiont of Psyllids: Providing Toxins, Vitamins, and Carotenoids

Genome biology and evolution, 2020-11, Vol.12 (11), p.1975-1987

2020

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Metabolites from symbiotic bacteria

Natural product reports, 2004-08, Vol.21 (4), p.519-538

Piel, Jorn

2004

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Automated structure prediction of trans-acyltransferase polyketide synthase products

Nature chemical biology, 2019-08, Vol.15 (8), p.813

2019

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Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides

Science (American Association for the Advancement of Science), 2012-10, Vol.338 (6105), p.387-390

2012

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Autocatalytic backbone N-methylation in a family of ribosomal peptide natural products

Nature chemical biology, 2017-08, Vol.13 (8), p.833

2017

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Ribosomally derived lipopeptides containing distinct fatty acyl moieties

Proceedings of the National Academy of Sciences - PNAS, 2022-01, Vol.119 (3)

2022

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Natural noncanonical protein splicing yields products with diverse β-amino acid residues

Science (American Association for the Advancement of Science), 2018-02, Vol.359 (6377), p.779-782

2018

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Landornamides: Antiviral Ornithine‐Containing Ribosomal Peptides Discovered through Genome Mining

Angewandte Chemie (International ed.), 2020-07, Vol.59 (29), p.11763-11768

International ed. in English, 2020

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Phylum-wide comparative genomics unravel the diversity of secondary metabolism in Cyanobacteria

BMC genomics, 2014-11, Vol.15 (1), p.977-977, Article 977

2014

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Insights into the lifestyle of uncultured bacterial natural product factories associated with marine sponges

Proceedings of the National Academy of Sciences - PNAS, 2017-01, Vol.114 (3), p.E347-E356

2017

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Polytheonamide biosynthesis showcasing the metabolic potential of sponge-associated uncultivated ‘Entotheonella’ bacteria

Current opinion in chemical biology, 2016-04, Vol.31, p.8-14

2016

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Genome mining- and synthetic biology-enabled production of hypermodified peptides

Nature chemistry, 2019-10, Vol.11 (10), p.931

2019

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Paradigm Shift for Radical S‑Adenosyl‑l‑methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis

Journal of the American Chemical Society, 2018-07, Vol.140 (28), p.8634-8638

2018

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Enzymatic spiroketal formation via oxidative rearrangement of pentangular polyketides

Nature communications, 2021-03, Vol.12 (1), p.1431-1431, Article 1431

2021

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The genus Pseudovibrio contains metabolically versatile bacteria adapted for symbiosis

Environmental microbiology, 2013-07, Vol.15 (7), p.2095-2113

2013

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Opening up the Single‐Cell Toolbox for Microbial Natural Products Research

Angewandte Chemie (International ed.), 2021-08, Vol.60 (34), p.18412-18428

International ed. in English, 2021

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Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria

Nature communications, 2021-03, Vol.12 (1), p.1422-1422, Article 1422

2021

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Strategies to access biosynthetic novelty in bacterial genomes for drug discovery

A roadmap for metagenomic enzyme discovery

Biosynthesis of polyketides by trans-AT polyketide synthases

A Polyketide Synthase-Peptide Synthetase Gene Cluster from an Uncultured Bacterial Symbiont of Paederus Beetles

In Vivo Production of Diverse β‐Amino Acid‐Containing Proteins

Genomic insights into the marine sponge microbiome

Aranazoles: Extensively Chlorinated Nonribosomal Peptide–Polyketide Hybrids from the Cyanobacterium Fischerella sp. PCC 9339

Approaches to Capturing and Designing Biologically Active Small Molecules Produced by Uncultured Microbes

Comparative Genomics Underlines Multiple Roles of Profftella, an Obligate Symbiont of Psyllids: Providing Toxins, Vitamins, and Carotenoids

Metabolites from symbiotic bacteria

Automated structure prediction of trans-acyltransferase polyketide synthase products

Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides

Autocatalytic backbone N-methylation in a family of ribosomal peptide natural products

Ribosomally derived lipopeptides containing distinct fatty acyl moieties

Natural noncanonical protein splicing yields products with diverse β-amino acid residues

Landornamides: Antiviral Ornithine‐Containing Ribosomal Peptides Discovered through Genome Mining

Phylum-wide comparative genomics unravel the diversity of secondary metabolism in Cyanobacteria

Insights into the lifestyle of uncultured bacterial natural product factories associated with marine sponges

Polytheonamide biosynthesis showcasing the metabolic potential of sponge-associated uncultivated ‘Entotheonella’ bacteria

Genome mining- and synthetic biology-enabled production of hypermodified peptides

Paradigm Shift for Radical S‑Adenosyl‑l‑methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis

Enzymatic spiroketal formation via oxidative rearrangement of pentangular polyketides

The genus Pseudovibrio contains metabolically versatile bacteria adapted for symbiosis

Opening up the Single‐Cell Toolbox for Microbial Natural Products Research

Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria

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