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TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

The Journal of experimental medicine, 2016-05, Vol.213 (5), p.667-675

2016

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A Plaque-Specific Antibody Clears Existing β-amyloid Plaques in Alzheimer's Disease Mice

Neuron (Cambridge, Mass.), 2012-12, Vol.76 (5), p.908-920

2012

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Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer’s disease mice

Molecular neurodegeneration, 2023-08, Vol.18 (1), p.1-59, Article 59

2023

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Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis

Proceedings of the National Academy of Sciences - PNAS, 2012-09, Vol.109 (38), p.15502-15507

2012

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Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model

Molecular neurodegeneration, 2018-12, Vol.13 (1), p.65-65, Article 65

2018

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Clusterin Promotes Amyloid Plaque Formation and is Critical for Neuritic Toxicity in a Mouse Model of Alzheimer's Disease

Proceedings of the National Academy of Sciences - PNAS, 2002-08, Vol.99 (16), p.10843-10848

2002

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Advancing combination therapy for Alzheimer's disease

Alzheimer's & dementia : translational research & clinical interventions, 2020, Vol.6 (1), p.e12073-n/a

2020

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Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

Science translational medicine, 2011-06, Vol.3 (89), p.89ra57

2011

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The Low Density Lipoprotein Receptor Regulates the Level of Central Nervous System Human and Murine Apolipoprotein E but Does Not Modify Amyloid Plaque Pathology in PDAPP Mice

The Journal of biological chemistry, 2005-07, Vol.280 (27), p.25754-25759

2005

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Midlife Blood Pressure, Plasma β-Amyloid, and the Risk for Alzheimer Disease: The Honolulu Asia Aging Study

Hypertension (Dallas, Tex. 1979), 2012-04, Vol.59 (4), p.780-786

2012

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Evidence for peripheral clearance of cerebral Aβ protein following chronic, active Aβ immunization in PSAPP mice

Neurobiology of disease, 2003-10, Vol.14 (1), p.10-18

2003

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Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-β

Neurobiology of disease, 2005-06, Vol.19 (1), p.66-76

2005

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Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia

Nature medicine, 2001-03, Vol.7 (3), p.338-343

2001

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Safety and biomarker effects of solanezumab in patients with Alzheimer’s disease

Alzheimer's & dementia, 2012-07, Vol.8 (4), p.261-271

2012

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Scavenger Receptor Class B, Type I (SR-BI) is the Major Route for the Delivery of High Density Lipoprotein Cholesterol to the Steroidogenic Pathway in Cultured Mouse Adrenocortical Cells

Proceedings of the National Academy of Sciences - PNAS, 1997-12, Vol.94 (25), p.13600-13605

1997

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A γ-secretase inhibitor decreases amyloid-β production in the central nervous system

Annals of neurology, 2009-07, Vol.66 (1), p.48-54

2009

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ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo

Journal of lipid research, 2008-06, Vol.49 (6), p.1254-1267

2008

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Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice

Neurochemistry international, 2001-11, Vol.39 (5), p.415-425

2001

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Brain to Plasma Amyloid-β Efflux: A Measure of Brain Amyloid Burden in a Mouse Model of Alzheimer's Disease

Science (American Association for the Advancement of Science), 2002-03, Vol.295 (5563), p.2264-2267

2002

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Safety and changes in plasma and cerebrospinal fluid amyloid beta after a single administration of an amyloid beta monoclonal antibody in subjects with Alzheimer disease

Clinical neuropharmacology, 2010-03, Vol.33 (2), p.67-73

2010

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Peripheral Anti-Aβ Antibody Alters CNS and Plasma Aβ Clearance and Decreases Brain Aβ Burden in a Mouse Model of Alzheimer's Disease

Proceedings of the National Academy of Sciences - PNAS, 2001-07, Vol.98 (15), p.8850-8855

2001

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Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model

Nature neuroscience, 2002-05, Vol.5 (5), p.452-457

2002

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The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of β-amyloid precursor protein

Journal of lipid research, 2007-05, Vol.48 (5), p.1022-1034

2007

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ApoE and Clusterin Cooperatively Suppress Aβ Levels and Deposition: Evidence that ApoE Regulates Extracellular Aβ Metabolism In Vivo

Neuron (Cambridge, Mass.), 2004-01, Vol.41 (2), p.193-202

2004

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In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life

The Journal of neuroscience, 2003-10, Vol.23 (26), p.8844-8853

2003

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TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

A Plaque-Specific Antibody Clears Existing β-amyloid Plaques in Alzheimer's Disease Mice

Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer’s disease mice

Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis

Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model

Clusterin Promotes Amyloid Plaque Formation and is Critical for Neuritic Toxicity in a Mouse Model of Alzheimer's Disease

Advancing combination therapy for Alzheimer's disease

Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

The Low Density Lipoprotein Receptor Regulates the Level of Central Nervous System Human and Murine Apolipoprotein E but Does Not Modify Amyloid Plaque Pathology in PDAPP Mice

Midlife Blood Pressure, Plasma β-Amyloid, and the Risk for Alzheimer Disease: The Honolulu Asia Aging Study

Evidence for peripheral clearance of cerebral Aβ protein following chronic, active Aβ immunization in PSAPP mice

Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-β

Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia

Safety and biomarker effects of solanezumab in patients with Alzheimer’s disease

Scavenger Receptor Class B, Type I (SR-BI) is the Major Route for the Delivery of High Density Lipoprotein Cholesterol to the Steroidogenic Pathway in Cultured Mouse Adrenocortical Cells

A γ-secretase inhibitor decreases amyloid-β production in the central nervous system

ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo

Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice

Brain to Plasma Amyloid-β Efflux: A Measure of Brain Amyloid Burden in a Mouse Model of Alzheimer's Disease

Safety and changes in plasma and cerebrospinal fluid amyloid beta after a single administration of an amyloid beta monoclonal antibody in subjects with Alzheimer disease

Peripheral Anti-Aβ Antibody Alters CNS and Plasma Aβ Clearance and Decreases Brain Aβ Burden in a Mouse Model of Alzheimer's Disease

Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model

The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of β-amyloid precursor protein

ApoE and Clusterin Cooperatively Suppress Aβ Levels and Deposition: Evidence that ApoE Regulates Extracellular Aβ Metabolism In Vivo

In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life

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