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Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease

Nature neuroscience, 2014-02, Vol.17 (2), p.304-311

2014

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Targeting the 26S Proteasome To Protect Against Proteotoxic Diseases

Trends in molecular medicine, 2018-01, Vol.24 (1), p.18-29

2018

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Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer’s Disease

Neuron (Cambridge, Mass.), 2017-02, Vol.93 (3), p.533-541.e5

2017

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Neuronal activity enhances tau propagation and tau pathology in vivo

Nature neuroscience, 2016-08, Vol.19 (8), p.1085

2016

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Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

The Journal of biological chemistry, 2013-01, Vol.288 (3), p.1856-1870

2013

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Mechanisms of protein seeding in neurodegenerative diseases

JAMA neurology, 2013-03, Vol.70 (3), p.304

2013

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Selective vulnerability in neurodegenerative diseases

Nature neuroscience, 2018-10, Vol.21 (10), p.1350

2018

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Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus

PLoS biology, 2020-08, Vol.18 (8), p.e3000851-e3000851

2020

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Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology

Nature communications, 2017-11, Vol.8 (1), p.1464-14, Article 1464

2017

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Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo

Autophagy, 2012-04, Vol.8 (4), p.609-622

2012

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PAC1 receptor-mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain

Science translational medicine, 2021-05, Vol.13 (595)

2021

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The Endosomal-Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo

Frontiers in neuroscience, 2017-12, Vol.11, p.702-702

2017

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Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits

The Journal of neuroscience, 2010-12, Vol.30 (49), p.16419-16428

2010

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Anesthesia Leads to Tau Hyperphosphorylation through Inhibition of Phosphatase Activity by Hypothermia

The Journal of neuroscience, 2007-03, Vol.27 (12), p.3090-3097

2007

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In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease

Science advances, 2021-10, Vol.7 (44), p.eabh1448-eabh1448

2021

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Microarray analysis of CA1 pyramidal neurons in a mouse model of tauopathy reveals progressive synaptic dysfunction

Neurobiology of disease, 2012-02, Vol.45 (2), p.751-762

2012

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Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice

Translational psychiatry, 2022-03, Vol.12 (1), p.129-129, Article 129

2022

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Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer's disease

Acta neuropathologica communications, 2022-12, Vol.10 (1), p.188-188, Article 188

2022

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3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice

PloS one, 2016-07, Vol.11 (7), p.e0159463-e0159463

2016

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Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia

The FASEB journal, 2009-08, Vol.23 (8), p.2595-2604

2009

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Tau-targeting antibody therapies: too late, wrong epitope or wrong target?

Nature medicine, 2021-08, Vol.27 (8), p.1341-1342

2021

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Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden

Molecular neurodegeneration, 2010-11, Vol.5 (1), p.45-45, Article 45

2010

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Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

Nature medicine, 2016-01, Vol.22 (1), p.46-53

2016

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P62 accumulates through neuroanatomical circuits in response to tauopathy propagation

Acta neuropathologica communications, 2021-11, Vol.9 (1), p.177-177, Article 177

2021

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Structure−Activity Relationship of Cyanine Tau Aggregation Inhibitors

Journal of medicinal chemistry, 2009-06, Vol.52 (11), p.3539-3547

2009

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Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease

Targeting the 26S Proteasome To Protect Against Proteotoxic Diseases

Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer’s Disease

Neuronal activity enhances tau propagation and tau pathology in vivo

Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

Mechanisms of protein seeding in neurodegenerative diseases

Selective vulnerability in neurodegenerative diseases

Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus

Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology

Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo

PAC1 receptor-mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain

The Endosomal-Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo

Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits

Anesthesia Leads to Tau Hyperphosphorylation through Inhibition of Phosphatase Activity by Hypothermia

In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease

Microarray analysis of CA1 pyramidal neurons in a mouse model of tauopathy reveals progressive synaptic dysfunction

Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice

Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer's disease

3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice

Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia

Tau-targeting antibody therapies: too late, wrong epitope or wrong target?

Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

P62 accumulates through neuroanatomical circuits in response to tauopathy propagation

Structure−Activity Relationship of Cyanine Tau Aggregation Inhibitors

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