UB Paderborn / Katalog / Suche / in CDI

Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs

Nature structural & molecular biology, 2014-09, Vol.21 (9), p.803

2014

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Structure–Kinetic Relationship Studies for the Development of Long Residence Time LpxC Inhibitors

Journal of medicinal chemistry, 2022-09, Vol.65 (17), p.11854-11875

2022

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Evaluating crystal structures of LpxC from Pseudomonas aeruginosa (paLpxC) in complex with new small-molecule inhibitors

Acta crystallographica. Section A, Foundations and advances, 2022-07, Vol.78 (a1), p.a287-a287

Delker, Silvia

2022

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Structural insights into the function of the catalytically active human Taspase1

Structure (London), 2021-08, Vol.29 (8), p.873-885.e5

2021

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Unexpected Binding Modes of Nitric Oxide Synthase Inhibitors Effective in the Prevention of a Cerebral Palsy Phenotype in an Animal Model

Journal of the American Chemical Society, 2010-04, Vol.132 (15), p.5437-5442

2010

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Potent, Highly Selective, and Orally Bioavailable Gem-Difluorinated Monocationic Inhibitors of Neuronal Nitric Oxide Synthase

Journal of the American Chemical Society, 2010-10, Vol.132 (40), p.14229-14238

2010

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Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor

Bioorganic & medicinal chemistry letters, 2012-02, Vol.22 (3), p.1433-1438

2012

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Role of Zinc in Isoform-Selective Inhibitor Binding to Neuronal Nitric Oxide Synthase

Biochemistry (Easton), 2010-12, Vol.49 (51), p.10803-10810

2010

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Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives

Journal of medicinal chemistry, 2010-11, Vol.53 (21), p.7804-7824

2010

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Crystal structures of PRK1 in complex with the clinical compounds lestaurtinib and tofacitinib reveal ligand induced conformational changes

PloS one, 2014-08, Vol.9 (8), p.e103638-e103638

2014

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Symmetric Double-Headed Aminopyridines, a Novel Strategy for Potent and Membrane-Permeable Inhibitors of Neuronal Nitric Oxide Synthase

Journal of medicinal chemistry, 2011-04, Vol.54 (7), p.2039-2048

2011

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Extension of Drosophila melanogaster life span with a GPCR peptide inhibitor

Nature chemical biology, 2007-07, Vol.3 (7), p.415-419

2007

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Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase

Bioorganic & medicinal chemistry, 2013-03, Vol.21 (5), p.1333-1343

2013

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Unexpected Binding Modes of Nitric Oxide Synthase Inhibitors Effective in the Prevention of a Cerebral Palsy Phenotype in an Animal Model

Journal of the American Chemical Society, 2010-10, Vol.132 (41), p.14688-14688

2010

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The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen

Journal of medicinal chemistry, 2017-11, Vol.60 (21), p.8989-9002

2017

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New structural insights into the function of the catalytically active human Taspase1

Acta crystallographica. Section A, Foundations and advances, 2021-07, Vol.77 (a1), p.a110-a110

2021

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New Structural Insights into the Function of the Active Full Length Human Taspase1: A Novel Anticancer Therapeutic Target

Biophysical journal, 2020-02, Vol.118 (3), p.42a-42a

2020

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The Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme–Inhibitor Interactions in Nitric Oxide Synthases

Biochemistry (Easton), 2014-08, Vol.53 (32), p.5272-5279

2014

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Structure Determination of Active Full Length Human Taspase1: Towards Novel Anti-Cancer Therapeutics

Biophysical journal, 2019-02, Vol.116 (3), p.17

2019

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Inhibitor Binding Mode Differences Within the AGC Subfamily

Acta crystallographica. Section A, Foundations and advances, 2014-08, Vol.70 (a1), p.C1640-C1640

2014

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Crystallographic studies of ligand binding by Zn-α2-glycoprotein

Journal of structural biology, 2004-11, Vol.148 (2), p.205-213

2004

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Extension of Drosophila melanogaster lifespan with a GPCR peptide inhibitor

Nature chemical biology, 2007-06, Vol.3 (7), p.415-419

2007

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Delineating the structural basis of ligand binding within constitutive nitric oxide synthases: An analysis of isoform selective inhibitors crystallographically, enzymatically, and computationally

Delker, Silvia L

2009

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ProQuest

Crystallographic studies of ligand binding by Zn-α 2-glycoprotein

Journal of structural biology, 2004, Vol.148 (2), p.205-213

2004

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Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs

Structure–Kinetic Relationship Studies for the Development of Long Residence Time LpxC Inhibitors

Evaluating crystal structures of LpxC from Pseudomonas aeruginosa (paLpxC) in complex with new small-molecule inhibitors

Structural insights into the function of the catalytically active human Taspase1

Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba

Unexpected Binding Modes of Nitric Oxide Synthase Inhibitors Effective in the Prevention of a Cerebral Palsy Phenotype in an Animal Model

Potent, Highly Selective, and Orally Bioavailable Gem-Difluorinated Monocationic Inhibitors of Neuronal Nitric Oxide Synthase

Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor

Role of Zinc in Isoform-Selective Inhibitor Binding to Neuronal Nitric Oxide Synthase

Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives

Crystal structures of PRK1 in complex with the clinical compounds lestaurtinib and tofacitinib reveal ligand induced conformational changes

Symmetric Double-Headed Aminopyridines, a Novel Strategy for Potent and Membrane-Permeable Inhibitors of Neuronal Nitric Oxide Synthase

Extension of Drosophila melanogaster life span with a GPCR peptide inhibitor

Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase

Unexpected Binding Modes of Nitric Oxide Synthase Inhibitors Effective in the Prevention of a Cerebral Palsy Phenotype in an Animal Model

The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen

New structural insights into the function of the catalytically active human Taspase1

New Structural Insights into the Function of the Active Full Length Human Taspase1: A Novel Anticancer Therapeutic Target

The Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme–Inhibitor Interactions in Nitric Oxide Synthases

Structure Determination of Active Full Length Human Taspase1: Towards Novel Anti-Cancer Therapeutics

Inhibitor Binding Mode Differences Within the AGC Subfamily

Crystallographic studies of ligand binding by Zn-α2-glycoprotein

Extension of Drosophila melanogaster lifespan with a GPCR peptide inhibitor

Delineating the structural basis of ligand binding within constitutive nitric oxide synthases: An analysis of isoform selective inhibitors crystallographically, enzymatically, and computationally

Crystallographic studies of ligand binding by Zn-α 2-glycoprotein

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