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Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity

Bioorganic & medicinal chemistry letters, 2013-01, Vol.23 (1), p.360-365

2013

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Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor

Journal of medicinal chemistry, 2009-03, Vol.52 (6), p.1522-1524

2009

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Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-a Inhibitor

Journal of medicinal chemistry, 2009-03, Vol.52 (6), p.1522-1524

2009

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Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor

Bioorganic & medicinal chemistry letters, 2012-02, Vol.22 (3), p.1433-1438

2012

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Bexarotene metabolism in rat, dog, and human, synthesis of oxidative metabolites, and in vitro activity at retinoid receptors

Drug metabolism and disposition, 2001-07, Vol.29 (7), p.990

2001

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Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury

Bioorganic & medicinal chemistry letters, 2012-02, Vol.22 (3), p.1427-1432

2012

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The synthetic compound CC-5079 is a potent inhibitor of tubulin polymerization and tumor necrosis factor-α production with antitumor activity

Cancer research (Chicago, Ill.), 2006-01, Vol.66 (2), p.951-959

2006

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Chemoprevention of mammary carcinoma by LGD1069 (Targretin) : An RXR-selective ligand

Cancer research (Chicago, Ill.), 1996-12, Vol.56 (24), p.5566-5570

1996

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The Effect of Australian Pine (Casuarina equisetifolia) Removal on Loggerhead Sea Turtle (Caretta caretta) Incubation Temperatures on Keewaydin Island, Florida

Journal of coastal research, 2008-07, Vol.10055 (10055), p.214-220

2008

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9-cis-Retinoic Acid Suppresses Mammary Tumorigenesis in C3(1)-Simian Virus 40 T Antigen-transgenic Mice

Clinical cancer research, 2000-09, Vol.6 (9), p.3696-3704

2000

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Orally administered lenalidomide (CC-5013) is anti-angiogenic in vivo and inhibits endothelial cell migration and Akt phosphorylation in vitro

Microvascular research, 2005, Vol.69 (1), p.56-63

2005

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Oxidative metabolism of a rexinoid and rapid phase II metabolite identification by mass spectrometry

Drug metabolism and disposition, 1997-10, Vol.25 (10), p.1144

1997

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Reducing the risk of acid aspiration during cesarean section

Anesthesia and analgesia, 1974-11, Vol.53 (6), p.859-868

1974

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The Effect of Australian Pine (Casuarina equisetifolia) Removal on Loggerhead Sea Turtle (Caretta caretta) Incubation Temperatures on Keewaydin Island, Florida

Journal of coastal research, 2008-10, Vol.SI (55), p.214-214

2008

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Effects of retinoid treatment of rats on hepatic microsomal metabolism and cytochromes P450. Correlation between retinoic acid receptor/retinoid x receptor selectivity and effects on metabolic enzymes

Drug metabolism and disposition, 1998-03, Vol.26 (3), p.234

1998

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Metabolite interference in pharmacokinetic studies

Drug metabolism letters, 2007-12, Vol.1 (4), p.272

2007

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Discovery of (S)-N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl] acetamide (apremilast), a potent and orally active phosphodiesterase 4 and tumor necrosis factor-alpha inhibitor

Journal of medicinal chemistry, 2009-03, Vol.52 (6), p.1522-1524

2009

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Oxidative and reductive metabolism of 9-cis-retinoic acid in the rat. Identification of 13,14-dihydro-9-cis-retinoic acid and its taurine conjugate

Drug metabolism and disposition, 1996-03, Vol.24 (3), p.293

1996

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REDUCING THE RISK OF ACID ASPIRATION DURING CESAREAN SECTION

Obstetrical & gynecological survey, 1975-07, Vol.30 (7), p.430-431

1975

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Metabolism of leukotriene B4 in isolated rat hepatocytes. Involvement of 2,4-dienoyl-coenzyme A reductase in leukotriene B4 metabolism

The Journal of biological chemistry, 1990-09, Vol.265 (27), p.16288-16295

1990

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Novel 3-hydroxylated leukotriene B 4 metabolites from ethanol-treated rat hepatocytes

Journal of the American Society for Mass Spectrometry, 1992-10, Vol.3 (7), p.762-768

1992

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Metabolism of LTB 4 by Isolated Hepatocytes: New Metabolites and Effect of Ethanol a

Annals of the New York Academy of Sciences, 1991-07, Vol.629 (1), p.410-412

1991

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Metabolism of LTB4 by Isolated Hepatocytes: New Metabolites and Effect of Ethanola

Annals of the New York Academy of Sciences, 1991-07, Vol.629 (1), p.410-412

1991

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Chemotactic LTB4 metabolites produced by hepatocytes in the presence of ethanol

Biochemical and biophysical research communications, 1992-06, Vol.185 (2), p.604-610

1992

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Chemotactic LTB 4 metabolites produced by hepatocytes in the presence of ethanol

Biochemical and biophysical research communications, 1992, Vol.185 (2), p.604-610

1992

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Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity

Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor

Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-a Inhibitor

Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor

Bexarotene metabolism in rat, dog, and human, synthesis of oxidative metabolites, and in vitro activity at retinoid receptors

Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury

The synthetic compound CC-5079 is a potent inhibitor of tubulin polymerization and tumor necrosis factor-α production with antitumor activity

Chemoprevention of mammary carcinoma by LGD1069 (Targretin) : An RXR-selective ligand

The Effect of Australian Pine (Casuarina equisetifolia) Removal on Loggerhead Sea Turtle (Caretta caretta) Incubation Temperatures on Keewaydin Island, Florida

9-cis-Retinoic Acid Suppresses Mammary Tumorigenesis in C3(1)-Simian Virus 40 T Antigen-transgenic Mice

Orally administered lenalidomide (CC-5013) is anti-angiogenic in vivo and inhibits endothelial cell migration and Akt phosphorylation in vitro

Oxidative metabolism of a rexinoid and rapid phase II metabolite identification by mass spectrometry

Reducing the risk of acid aspiration during cesarean section

The Effect of Australian Pine (Casuarina equisetifolia) Removal on Loggerhead Sea Turtle (Caretta caretta) Incubation Temperatures on Keewaydin Island, Florida

Effects of retinoid treatment of rats on hepatic microsomal metabolism and cytochromes P450. Correlation between retinoic acid receptor/retinoid x receptor selectivity and effects on metabolic enzymes

Metabolite interference in pharmacokinetic studies

Discovery of (S)-N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl] acetamide (apremilast), a potent and orally active phosphodiesterase 4 and tumor necrosis factor-alpha inhibitor

Oxidative and reductive metabolism of 9-cis-retinoic acid in the rat. Identification of 13,14-dihydro-9-cis-retinoic acid and its taurine conjugate

REDUCING THE RISK OF ACID ASPIRATION DURING CESAREAN SECTION

Metabolism of leukotriene B4 in isolated rat hepatocytes. Involvement of 2,4-dienoyl-coenzyme A reductase in leukotriene B4 metabolism

Novel 3-hydroxylated leukotriene B 4 metabolites from ethanol-treated rat hepatocytes

Metabolism of LTB 4 by Isolated Hepatocytes: New Metabolites and Effect of Ethanol a

Metabolism of LTB4 by Isolated Hepatocytes: New Metabolites and Effect of Ethanola

Chemotactic LTB4 metabolites produced by hepatocytes in the presence of ethanol

Chemotactic LTB 4 metabolites produced by hepatocytes in the presence of ethanol

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