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Pyridine-3-carboxamide-6-yl-ureas as novel inhibitors of bacterial DNA gyrase: Structure based design, synthesis, SAR and antimicrobial activity

European journal of medicinal chemistry, 2014-10, Vol.86, p.31-38

2014

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Design, synthesis and structure-activity relationships of substituted oxazole-benzamide antibacterial inhibitors of FtsZ

Bioorganic & medicinal chemistry letters, 2014-01, Vol.24 (1), p.353-359

2014

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Pseudomonas aeruginosa elastase (LasB) as a therapeutic target

Drug discovery today, 2021-09, Vol.26 (9), p.2108-2123

2021

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Designing Inhibitors of β‑Lactamase Enzymes to Overcome Carbapenem Resistance in Gram-Negative Bacteria

Accounts of chemical research, 2021-05, Vol.54 (9), p.2055-2064

2021

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Discovery of a Novel Metallo-β-Lactamase Inhibitor That Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacteriaceae

Antimicrobial agents and chemotherapy, 2018-05, Vol.62 (5)

2018

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A Flexible, Stereoselective Approach to the Decorated cis-Hydrindane Skeleton: Synthesis of the Proposed Structure of Faurinone

Chemistry : a European journal, 2008-08, Vol.14 (23), p.6862-6865

2008

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A catalytic asymmetric protocol for the enantioselective synthesis of 3(2H)-furanones

Chemical communications (Cambridge, England), 2007-01 (24), p.2494-2496

2007

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Preparation of N-Heterocycles by Radical Cyclisation of Enamides Mediated by Manganese(III) or Copper(I). A Comparison of Cyclisation Methods

Tetrahedron, 2000-06, Vol.56 (24), p.3941-3949

2000

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Chemical Optimization of Selective Pseudomonas aeruginosa LasB Elastase Inhibitors and Their Impact on LasB-Mediated Activation of IL-1β in Cellular and Animal Infection Models

ACS infectious diseases, 2023-02, Vol.9 (2), p.270-282

2023

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Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases

Bioorganic & medicinal chemistry letters, 2016-05, Vol.26 (10), p.2464-2469

2016

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Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases

Bioorganic & medicinal chemistry letters, 2013-10, Vol.23 (19), p.5437-5441

2013

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SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model

ACS infectious diseases, 2019-01, Vol.5 (1), p.131-140

2019

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Virtual Screening Approach to Identifying a Novel and Tractable Series of Pseudomonas aeruginosa Elastase Inhibitors

ACS medicinal chemistry letters, 2021-02, Vol.12 (2), p.217-227

2021

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ANT2681: SAR Studies Leading to the Identification of a Metallo-β-lactamase Inhibitor with Potential for Clinical Use in Combination with Meropenem for the Treatment of Infections Caused by NDM-Producing Enterobacteriaceae

ACS infectious diseases, 2020-09, Vol.6 (9), p.2419-2430

2020

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Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases

Bioorganic & medicinal chemistry letters, 2011-12, Vol.21 (24), p.7483-7488

2011

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Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases

Bioorganic & medicinal chemistry letters, 2011-12, Vol.21 (24), p.7489-7495

2011

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Design, synthesis and biological evaluation of α-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors

Bioorganic & medicinal chemistry letters, 2013-12, Vol.23 (24), p.6598-6603

2013

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Discovery and in vivo evaluation of alcohol-containing benzothiazoles as potent dual-targeting bacterial DNA supercoiling inhibitors

Bioorganic & medicinal chemistry letters, 2014-09, Vol.24 (17), p.4215-4222

2014

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A stereoselective, Sm(II)-mediated approach to decorated cis-hydrindanes: synthetic studies on faurinone and pleuromutilin

Organic & biomolecular chemistry, 2011-04, Vol.9 (7), p.2433-2451

2011

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Curriculum Challenges for Universities: Agenda for Change

1, 2022

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Towards Gender Equality in Law: An Analysis of State Failures from a Global Perspective

1, 2022

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Novel and Selective 5-HT2C/2B Receptor Antagonists as Potential Anxiolytic Agents: Synthesis, Quantitative Structure−Activity Relationships, and Molecular Modeling of Substituted 1-(3-Pyridylcarbamoyl)indolines

Journal of medicinal chemistry, 1998-05, Vol.41 (10), p.1598-1612

1998

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The Chemistry of Pseudomonic Acid. † 15. Synthesis and Antibacterial Activity of a Series of 5-Alkyl, 5-Alkenyl, and 5-Heterosubstituted Oxazoles

Journal of medicinal chemistry, 1996-01, Vol.39 (2), p.446-457

1996

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Pyridine-3-carboxamide-6-yl-ureas as novel inhibitors of bacterial DNA gyrase: Structure based design, synthesis, SAR and antimicrobial activity

Design, synthesis and structure-activity relationships of substituted oxazole-benzamide antibacterial inhibitors of FtsZ

Pseudomonas aeruginosa elastase (LasB) as a therapeutic target

Designing Inhibitors of β‑Lactamase Enzymes to Overcome Carbapenem Resistance in Gram-Negative Bacteria

Discovery of a Novel Metallo-β-Lactamase Inhibitor That Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacteriaceae

A Flexible, Stereoselective Approach to the Decorated cis-Hydrindane Skeleton: Synthesis of the Proposed Structure of Faurinone

A catalytic asymmetric protocol for the enantioselective synthesis of 3(2H)-furanones

Discovery of ANT3310, a Novel Broad-Spectrum Serine β‑Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacterales and Acinetobacter baumannii

Preparation of N-Heterocycles by Radical Cyclisation of Enamides Mediated by Manganese(III) or Copper(I). A Comparison of Cyclisation Methods

Chemical Optimization of Selective Pseudomonas aeruginosa LasB Elastase Inhibitors and Their Impact on LasB-Mediated Activation of IL-1β in Cellular and Animal Infection Models

Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases

Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases

SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model

Virtual Screening Approach to Identifying a Novel and Tractable Series of Pseudomonas aeruginosa Elastase Inhibitors

ANT2681: SAR Studies Leading to the Identification of a Metallo-β-lactamase Inhibitor with Potential for Clinical Use in Combination with Meropenem for the Treatment of Infections Caused by NDM-Producing Enterobacteriaceae

Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases

Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases

Design, synthesis and biological evaluation of α-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors

Discovery and in vivo evaluation of alcohol-containing benzothiazoles as potent dual-targeting bacterial DNA supercoiling inhibitors

A stereoselective, Sm(II)-mediated approach to decorated cis-hydrindanes: synthetic studies on faurinone and pleuromutilin

Curriculum Challenges for Universities: Agenda for Change

Towards Gender Equality in Law: An Analysis of State Failures from a Global Perspective

Biarylcarbamoylindolines Are Novel and Selective 5-HT2C Receptor Inverse Agonists: Identification of 5-Methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a Potential Antidepressant/Anxiolytic Agent

Novel and Selective 5-HT2C/2B Receptor Antagonists as Potential Anxiolytic Agents: Synthesis, Quantitative Structure−Activity Relationships, and Molecular Modeling of Substituted 1-(3-Pyridylcarbamoyl)indolines

The Chemistry of Pseudomonic Acid. † 15. Synthesis and Antibacterial Activity of a Series of 5-Alkyl, 5-Alkenyl, and 5-Heterosubstituted Oxazoles

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