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The utility of target-based discovery

Expert opinion on drug discovery, 2017-05, Vol.12 (5), p.427-429

Croston, Glenn E.

2017

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Movement to the Clinic of Soluble Epoxide Hydrolase Inhibitor EC5026 as an Analgesic for Neuropathic Pain and for Use as a Nonaddictive Opioid Alternative

Journal of medicinal chemistry, 2021-02, Vol.64 (4), p.1856-1872

2021

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Quinagolide Treatment Reduces Invasive and Angiogenic Properties of Endometrial Mesenchymal Stromal Cells

International journal of molecular sciences, 2022-02, Vol.23 (3), p.1775

2022

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Protective Mechanism of the Selective Vasopressin V 1A Receptor Agonist Selepressin against Endothelial Barrier Dysfunction

The Journal of pharmacology and experimental therapeutics, 2020-11, Vol.375 (2), p.286-295

2020

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Comparative pharmacology of a new recombinant FSH expressed by a human cell line

Endocrine Connections, 2017-07, Vol.6 (5), p.297-305

2017

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New, Potent, and Selective Peptidic Oxytocin Receptor Agonists

Journal of medicinal chemistry, 2014-06, Vol.57 (12), p.5306-5317

2014

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Functional cell-based uHTS in chemical genomic drug discovery

Trends in Biotechnology, 2002-03, Vol.20 (3), p.110-115

Croston, Glenn E

2002

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A Selective Peroxisome Proliferator-Activated Receptor-γ (PPARγ) Modulator Blocks Adipocyte Differentiation but Stimulates Glucose Uptake in 3T3-L1 Adipocytes

Molecular endocrinology (Baltimore, Md.), 2000-09, Vol.14 (9), p.1425-1433

2000

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Identification of novel subtype selective RAR agonists

Biochemical pharmacology, 2005-12, Vol.71 (1), p.156-162

2005

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Activation of specific RXR heterodimers by an antagonist of RXR homodimers

Nature (London), 1996-10, Vol.383 (6599), p.450-453

1996

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Discovery of the First Nonpeptide Agonist of the GPR14/Urotensin-II Receptor: 3-(4-Chlorophenyl)-3-(2- (dimethylamino)ethyl)isochroman-1-one (AC-7954)

Journal of medicinal chemistry, 2002-11, Vol.45 (23), p.4950-4953

2002

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Pharmacological Characterization of Apraglutide, a Novel Long-Acting Peptidic Glucagon-Like Peptide-2 Agonist, for the Treatment of Short Bowel Syndrome

The Journal of pharmacology and experimental therapeutics, 2020-05, Vol.373 (2), p.193-203

2020

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Sequence-Specific Antirepression of Histone H1-Mediated Inhibition of Basal RNA Polymerase II Transcription

Science (American Association for the Advancement of Science), 1991-02, Vol.251 (4994), p.643-649

1991

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Androgen Receptor-Mediated Antagonism of Estrogen-Dependent Low Density Lipoprotein Receptor Transcription in Cultured Hepatocytes

Endocrinology (Philadelphia), 1997-09, Vol.138 (9), p.3779-3786

1997

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Synthesis of Retinoid X Receptor-Specific Ligands That Are Potent Inducers of Adipogenesis in 3T3-L1 Cells

Journal of medicinal chemistry, 1999-02, Vol.42 (4), p.742-750

1999

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Selective Partial Agonism of Vasopressin 1a Receptors In Vitro by OCE-205

Journal of pharmacology & pharmacotherapeutics, 2023-03, Vol.14 (1), p.54-61

2023

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Identification of the First Retinoid X Receptor Homodimer Antagonist

Journal of medicinal chemistry, 1996-08, Vol.39 (17), p.3229-3234

1996

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Identification, Characterization, and Tissue Distribution of Human Peroxisome Proliferator-activated Receptor (PPAR) Isoforms PPARγ2 versus PPARγ1 and Activation with Retinoid X Receptor Agonists and Antagonists

The Journal of biological chemistry, 1997-03, Vol.272 (12), p.8071-8076

1997

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Modulating the Barrier Function of Human Alveolar Epithelial (hAELVi) Cell Monolayers as a Model of Inflammation

Alternatives to laboratory animals, 2020-09, Vol.48 (5-6), p.252-267

2020

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Discovery of Potent, Selective, and Short-Acting Peptidic V 2 Receptor Agonists

Journal of medicinal chemistry, 2019-05, Vol.62 (10), p.4991-5005

2019

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Rationale for haploinsufficiency correction therapy in neurofibromatosis type 1

Journal of Translational Genetics and Genomics, 2022, Vol.6 (4), p.403-28

2022

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Discovery of Potent, Selective, and Short-Acting Peptidic V2 Receptor Agonists

Journal of medicinal chemistry, 2019-05, Vol.62 (10), p.4991-5005

2019

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Synthesis and Pharmacological Characterization of Novel Glucagon-like Peptide‑2 (GLP-2) Analogues with Low Systemic Clearance

Journal of medicinal chemistry, 2016-04, Vol.59 (7), p.3129-3139

2016

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New, Potent, Selective, and Short-Acting Peptidic V 1a Receptor Agonists

Journal of medicinal chemistry, 2011-07, Vol.54 (13), p.4388-4398

2011

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Pharmacological Characterization of FE 202158, a Novel, Potent, Selective, and Short-Acting Peptidic Vasopressin V 1a Receptor Full Agonist for the Treatment of Vasodilatory Hypotension

The Journal of pharmacology and experimental therapeutics, 2011-06, Vol.337 (3), p.786-796

2011

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The utility of target-based discovery

Movement to the Clinic of Soluble Epoxide Hydrolase Inhibitor EC5026 as an Analgesic for Neuropathic Pain and for Use as a Nonaddictive Opioid Alternative

Quinagolide Treatment Reduces Invasive and Angiogenic Properties of Endometrial Mesenchymal Stromal Cells

Protective Mechanism of the Selective Vasopressin V 1A Receptor Agonist Selepressin against Endothelial Barrier Dysfunction

Comparative pharmacology of a new recombinant FSH expressed by a human cell line

New, Potent, and Selective Peptidic Oxytocin Receptor Agonists

Functional cell-based uHTS in chemical genomic drug discovery

A Selective Peroxisome Proliferator-Activated Receptor-γ (PPARγ) Modulator Blocks Adipocyte Differentiation but Stimulates Glucose Uptake in 3T3-L1 Adipocytes

Identification of novel subtype selective RAR agonists

Activation of specific RXR heterodimers by an antagonist of RXR homodimers

Discovery of the First Nonpeptide Agonist of the GPR14/Urotensin-II Receptor: 3-(4-Chlorophenyl)-3-(2- (dimethylamino)ethyl)isochroman-1-one (AC-7954)

Pharmacological Characterization of Apraglutide, a Novel Long-Acting Peptidic Glucagon-Like Peptide-2 Agonist, for the Treatment of Short Bowel Syndrome

Sequence-Specific Antirepression of Histone H1-Mediated Inhibition of Basal RNA Polymerase II Transcription

Androgen Receptor-Mediated Antagonism of Estrogen-Dependent Low Density Lipoprotein Receptor Transcription in Cultured Hepatocytes

Synthesis of Retinoid X Receptor-Specific Ligands That Are Potent Inducers of Adipogenesis in 3T3-L1 Cells

Selective Partial Agonism of Vasopressin 1a Receptors In Vitro by OCE-205

Identification of the First Retinoid X Receptor Homodimer Antagonist

Identification, Characterization, and Tissue Distribution of Human Peroxisome Proliferator-activated Receptor (PPAR) Isoforms PPARγ2 versus PPARγ1 and Activation with Retinoid X Receptor Agonists and Antagonists

Modulating the Barrier Function of Human Alveolar Epithelial (hAELVi) Cell Monolayers as a Model of Inflammation

Discovery of Potent, Selective, and Short-Acting Peptidic V 2 Receptor Agonists

Rationale for haploinsufficiency correction therapy in neurofibromatosis type 1

Discovery of Potent, Selective, and Short-Acting Peptidic V2 Receptor Agonists

Synthesis and Pharmacological Characterization of Novel Glucagon-like Peptide‑2 (GLP-2) Analogues with Low Systemic Clearance

New, Potent, Selective, and Short-Acting Peptidic V 1a Receptor Agonists

Pharmacological Characterization of FE 202158, a Novel, Potent, Selective, and Short-Acting Peptidic Vasopressin V 1a Receptor Full Agonist for the Treatment of Vasodilatory Hypotension

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