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Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

Molecular cell, 2015-07, Vol.59 (2), p.285-297

2015

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Perturbation of the c‑Myc–Max Protein–Protein Interaction via Synthetic α‑Helix Mimetics

Journal of medicinal chemistry, 2015-04, Vol.58 (7), p.3002-3024

2015

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Cell Survival and Cell Death at the Intersection of Autophagy and Apoptosis: Implications for Current and Future Cancer Therapeutics

ACS pharmacology & translational science, 2021-12, Vol.4 (6), p.1728-1746

2021

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Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer

Journal of medicinal chemistry, 2020-12, Vol.63 (23), p.14609-14625

2020

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Fully Automated Continuous Flow Synthesis of Highly Functionalized Imidazo[1,2-a] Heterocycles

Organic letters, 2010-02, Vol.12 (3), p.412-415

2010

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Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia

Journal of medicinal chemistry, 2022-01, Vol.65 (2), p.1352-1369

2022

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Autophagy in Cancer: Regulation by Small Molecules

Trends in pharmacological sciences (Regular ed.), 2018-12, Vol.39 (12), p.1021-1032

2018

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One-Step Continuous Flow Synthesis of Highly Substituted Pyrrole-3-carboxylic Acid Derivatives via in Situ Hydrolysis of tert-Butyl Esters

Organic letters, 2010-11, Vol.12 (22), p.5182-5185

2010

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Chemical Biology Investigation of Cell Death Pathways Activated by Endoplasmic Reticulum Stress Reveals Cytoprotective Modulators of ASK1

The Journal of biological chemistry, 2009-01, Vol.284 (3), p.1593-1603

2009

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BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency

Cell host & microbe, 2015-09, Vol.18 (3), p.345-353

2015

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Novel potent azetidine-based compounds irreversibly inhibit Stat3 activation and induce antitumor response against human breast tumor growth in vivo

Cancer letters, 2022-05, Vol.534, p.215613-215613, Article 215613

2022

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2‑Aminopyridines via Reaction of Pyridine N‑Oxides and Activated Isocyanides

Journal of organic chemistry, 2014-03, Vol.79 (5), p.2274-2280

2014

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Metabotropic Glutamate Receptor 5 as a Target for the Treatment of Depression and Smoking: Robust Preclinical Data but Inconclusive Clinical Efficacy

Biological psychiatry (1969), 2018-06, Vol.83 (11), p.955-962

2018

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Identification and Development of a New Positron Emission Tomography Ligand 4‑(2-Fluoro-4‑[11C]methoxyphenyl)-5-((1-methyl‑1H‑pyrazol-3-yl)methoxy)picolinamide for Imaging Metabotropic Glutamate Receptor Subtype 2 (mGlu2)

Journal of medicinal chemistry, 2020-10, Vol.63 (20), p.11469-11483

2020

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Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis

PloS one, 2016-09, Vol.11 (9), p.e0161952-e0161952

2016

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Small Molecules Can Selectively Inhibit Ephrin Binding to the EphA4 and EphA2 Receptors

The Journal of biological chemistry, 2008-10, Vol.283 (43), p.29461-29472

2008

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Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2)

Biochemical journal, 2019-03, Vol.476 (5), p.875-887

2019

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Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor

Bioorganic & medicinal chemistry letters, 2018-01, Vol.28 (1), p.31-34

2018

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Rapid Multistep Synthesis of 1,2,4-Oxadiazoles in a Single Continuous Microreactor Sequence

Journal of organic chemistry, 2008-09, Vol.73 (18), p.7219-7223

2008

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Detection of Cellular Target Engagement for Small-Molecule Modulators of Striatal-Enriched Protein Tyrosine Phosphatase (STEP)

Methods in molecular biology (Clifton, N.J.), 2023, Vol.2706, p.167

2023

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Targeting Unc51-like Autophagy Activating Kinase 1 (ULK1) Overcomes Adaptive Drug Resistance in Acute Myelogenous Leukemia

Molecular cancer research, 2023-06, Vol.21 (6), p.548-563

2023

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Continuous-flow synthesis of highly functionalized imidazo-oxadiazoles facilitated by microfluidic extraction

Beilstein journal of organic chemistry, 2017-02, Vol.13 (1), p.239-246

2017

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Automated Multistep Continuous Flow Synthesis of 2-(1H-Indol-3-yl)thiazole Derivatives

Synthesis (Stuttgart), 2012, Vol.44 (16), p.2537-2546

2012

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Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins

F1000 research, 2017, Vol.6, p.587-587

2017

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Design and Synthesis of Systemically Active Metabotropic Glutamate Subtype‑2 and -3 (mGlu2/3) Receptor Positive Allosteric Modulators (PAMs): Pharmacological Characterization and Assessment in a Rat Model of Cocaine Dependence

Journal of medicinal chemistry, 2014-05, Vol.57 (10), p.4154-4172

2014

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Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

Perturbation of the c‑Myc–Max Protein–Protein Interaction via Synthetic α‑Helix Mimetics

Cell Survival and Cell Death at the Intersection of Autophagy and Apoptosis: Implications for Current and Future Cancer Therapeutics

Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer

Fully Automated Continuous Flow Synthesis of Highly Functionalized Imidazo[1,2-a] Heterocycles

Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia

Autophagy in Cancer: Regulation by Small Molecules

One-Step Continuous Flow Synthesis of Highly Substituted Pyrrole-3-carboxylic Acid Derivatives via in Situ Hydrolysis of tert-Butyl Esters

Chemical Biology Investigation of Cell Death Pathways Activated by Endoplasmic Reticulum Stress Reveals Cytoprotective Modulators of ASK1

BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency

Novel potent azetidine-based compounds irreversibly inhibit Stat3 activation and induce antitumor response against human breast tumor growth in vivo

2‑Aminopyridines via Reaction of Pyridine N‑Oxides and Activated Isocyanides

Metabotropic Glutamate Receptor 5 as a Target for the Treatment of Depression and Smoking: Robust Preclinical Data but Inconclusive Clinical Efficacy

Identification and Development of a New Positron Emission Tomography Ligand 4‑(2-Fluoro-4‑[11C]methoxyphenyl)-5-((1-methyl‑1H‑pyrazol-3-yl)methoxy)picolinamide for Imaging Metabotropic Glutamate Receptor Subtype 2 (mGlu2)

Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis

Small Molecules Can Selectively Inhibit Ephrin Binding to the EphA4 and EphA2 Receptors

Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2)

Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor

Rapid Multistep Synthesis of 1,2,4-Oxadiazoles in a Single Continuous Microreactor Sequence

Detection of Cellular Target Engagement for Small-Molecule Modulators of Striatal-Enriched Protein Tyrosine Phosphatase (STEP)

Targeting Unc51-like Autophagy Activating Kinase 1 (ULK1) Overcomes Adaptive Drug Resistance in Acute Myelogenous Leukemia

Continuous-flow synthesis of highly functionalized imidazo-oxadiazoles facilitated by microfluidic extraction

Automated Multistep Continuous Flow Synthesis of 2-(1H-Indol-3-yl)thiazole Derivatives

Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins

Design and Synthesis of Systemically Active Metabotropic Glutamate Subtype‑2 and -3 (mGlu2/3) Receptor Positive Allosteric Modulators (PAMs): Pharmacological Characterization and Assessment in a Rat Model of Cocaine Dependence

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