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Engineered Cardiac Tissues Generated in the Biowire II: A Platform for Human-Based Drug Discovery

Toxicological sciences, 2019-11, Vol.172 (1), p.89-97

2019

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A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm

Journal of biomolecular screening, 2016-01, Vol.21 (1), p.1-11

2016

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CardioMotion: identification of functional and structural cardiotoxic liabilities in small molecules through brightfield kinetic imaging

Toxicological sciences, 2023-07, Vol.195 (1), p.61-70

2023

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Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes

Frontiers in pharmacology, 2019-08, Vol.10, p.934-934

2019

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Cardiac sodium channel inhibition by lamotrigine: In vitro characterization and clinical implications

Clinical and translational science, 2022-08, Vol.15 (8), p.1978-1989

2022

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Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off‐label in the first wave of COVID‐19

Clinical and translational science, 2021-05, Vol.14 (3), p.1133-1146

2021

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Considerations for an In Vitro , Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms

Frontiers in pharmacology, 2019-08, Vol.10, p.884-884

2019

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Cardiotoxicity screening with simultaneous optogenetic pacing, voltage imaging and calcium imaging

Journal of pharmacological and toxicological methods, 2016-09, Vol.81, p.240-250

2016

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Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells

Scientific reports, 2020-03, Vol.10 (1), p.5627, Article 5627

2020

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Discovery of Potent STT3A/B Inhibitors and Assessment of Their Multipathogen Antiviral Potential and Safety

Journal of medicinal chemistry, 2024-08, Vol.67 (16), p.14586-14608

2024

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Novel KV7 ion channel openers for the treatment of epilepsy and implications for detrusor tissue contraction

Bioorganic & medicinal chemistry letters, 2018-12, Vol.28 (23-24), p.3793-3797

2018

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Characterization of sodium channel blockade using inducible pluripotent stem cell-derived cardiomyocytes

Journal of pharmacological and toxicological methods, 2019-09, Vol.99, p.106595, Article 106595

2019

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In vitro methods for detecting drug-induced hERG trafficking deficiencies

Journal of pharmacological and toxicological methods, 2019-09, Vol.99, p.106595, Article 106595

2019

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Comparison of in silico action potential modeling (AP-Predict) and the hiPSc-CM MEA assay in predicting drug-induced cardiotoxicity

Journal of pharmacological and toxicological methods, 2019-09, Vol.99, p.106595, Article 106595

2019

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Publisher Correction: Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells

Scientific reports, 2020-07, Vol.10 (1), p.11884-11884, Article 11884

2020

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Evaluating the use of microelectrode array technology and cell-based neuronal culture models for proconvulsant risk assessment: progress from the HESI NeuTox consortium

Journal of pharmacological and toxicological methods, 2019-09, Vol.99, p.106595, Article 106595

2019

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Correction to Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel

ACS medicinal chemistry letters, 2020-06, Vol.11 (6), p.1353-1353

2020

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Altered myocardial Ca2+cycling after left ventricular assist device support in the failing human heart

Journal of the American College of Cardiology, 2004-08, Vol.44 (4), p.837-845

2004

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Abnormal frequency-dependent responses represent the pathophysiologic signature of contractile failure in human myocardium

Journal of molecular and cellular cardiology, 2004, Vol.36 (1), p.33-42

2004

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Variations in neuron: Glia ratio may alter sensitivity to detect seizurogenic potential of drugs

Journal of pharmacological and toxicological methods, 2021-09, Vol.111, p.106977, Article 106977

2021

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Cation chloride cotransporter modulation of the seizure phenotype in rat cortical MEA

Journal of pharmacological and toxicological methods, 2021-09, Vol.111, p.106984, Article 106984

2021

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Embryonic Stem Cells in Predictive Cardiotoxicity: Laser Capture Microscopy Enables Assay Development

Toxicological sciences, 2006-03, Vol.90 (1), p.149-158

2006

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Characterization of sodium channel blockade using the rabbit ventricular wedge preparation

Journal of pharmacological and toxicological methods, 2011-07, Vol.64 (1), p.e10-e11

2011

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Engineered Cardiac Tissues Generated in the Biowire II: A Platform for Human-Based Drug Discovery

A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm

CardioMotion: identification of functional and structural cardiotoxic liabilities in small molecules through brightfield kinetic imaging

Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes

Cardiac sodium channel inhibition by lamotrigine: In vitro characterization and clinical implications

Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off‐label in the first wave of COVID‐19

Considerations for an In Vitro , Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms

Cardiotoxicity screening with simultaneous optogenetic pacing, voltage imaging and calcium imaging

Time for a Fully Integrated Nonclinical–Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective

Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells

Discovery of Potent STT3A/B Inhibitors and Assessment of Their Multipathogen Antiviral Potential and Safety

Novel KV7 ion channel openers for the treatment of epilepsy and implications for detrusor tissue contraction

Characterization of sodium channel blockade using inducible pluripotent stem cell-derived cardiomyocytes

In vitro methods for detecting drug-induced hERG trafficking deficiencies

Comparison of in silico action potential modeling (AP-Predict) and the hiPSc-CM MEA assay in predicting drug-induced cardiotoxicity

Publisher Correction: Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells

Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel

Evaluating the use of microelectrode array technology and cell-based neuronal culture models for proconvulsant risk assessment: progress from the HESI NeuTox consortium

Correction to Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel

Altered myocardial Ca2+cycling after left ventricular assist device support in the failing human heart

Abnormal frequency-dependent responses represent the pathophysiologic signature of contractile failure in human myocardium

Variations in neuron: Glia ratio may alter sensitivity to detect seizurogenic potential of drugs

Cation chloride cotransporter modulation of the seizure phenotype in rat cortical MEA

Embryonic Stem Cells in Predictive Cardiotoxicity: Laser Capture Microscopy Enables Assay Development

Characterization of sodium channel blockade using the rabbit ventricular wedge preparation

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