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Evaluating the In Vitro Inhibition of UGT1A1, OATP1B1, OATP1B3, MRP2, and BSEP in Predicting Drug-Induced Hyperbilirubinemia

Molecular pharmaceutics, 2013-08, Vol.10 (8), p.3067-3075

2013

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Applying Stable Isotope Labeled Amino Acids in Micropatterned Hepatocyte Coculture to Directly Determine the Degradation Rate Constant for CYP3A4

Drug metabolism and disposition, 2017-06, Vol.45 (6), p.581-585

2017

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Comprehensive Evaluation of Bile Acid Homeostasis in Human Hepatocyte Co-Culture in the Presence of Troglitazone, Pioglitazone, and Acetylsalicylic Acid

Molecular pharmaceutics, 2019-10, Vol.16 (10), p.4230-4240

2019

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Insensitivity to Pain upon Adult-Onset Deletion of Nav1.7 or Its Blockade with Selective Inhibitors

The Journal of neuroscience, 2018-11, Vol.38 (47), p.10180-10201

2018

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Unequal Absorption of Radiolabeled and Nonradiolabeled Drug from the Oral Dose Leads to Incorrect Estimates of Drug Absorption and Circulating Metabolites in a Mass Balance Study

Drug metabolism letters, 2019, Vol.13 (1), p.37-44

2019

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Evaluation of a Competitive Equilibrium Dialysis Approach for Assessing the Impact of Protein Binding on Clearance Predictions

Journal of pharmaceutical sciences, 2021-01, Vol.110 (1), p.536-542

2021

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Sequential double-guidewire technique and transpancreatic precut sphincterotomy for difficult biliary cannulation

Saudi journal of gastroenterology, 2015-01, Vol.21 (1), p.18-24

2015

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GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer

Journal of medicinal chemistry, 2021-08, Vol.64 (16), p.11841-11856

2021

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Investigating the Utility of Humanized Pregnane X Receptor-Constitutive Androstane Receptor-CYP3A4/7 Mouse Model to Assess CYP3A-Mediated Induction

Drug metabolism and disposition, 2021-07, Vol.49 (7), p.540-547

2021

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The Role of pH in the Glucuronidation of Raloxifene, Mycophenolic Acid and Ezetimibe

Molecular pharmaceutics, 2009-08, Vol.6 (4), p.1216-1227

2009

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Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production

Journal of medicinal chemistry, 2020-09, Vol.63 (18), p.10433-10459

2020

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Investigating the Impact of Albumin on the Liver Uptake of Pitavastatin and Warfarin in Nagase Analbuminemic Rats

Drug metabolism and disposition, 2019-11, Vol.47 (11), p.1307-1313

2019

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Analysis of the bile acid composition in a fibroblast growth factor 19-expressing liver-humanized mouse model and its use for CYP3A4-mediated drug-drug interaction studies

Drug metabolism and disposition, 2023-10, Vol.51 (10), p.1391-1402

2023

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Repeat kidney transplant recipients with active rejection have elevated donor‐derived cell‐free DNA

American journal of transplantation, 2019-05, Vol.19 (5), p.1597-1598

2019

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Safety, Tolerability, and Pharmacokinetics of GDC-0276, a Novel NaV1.7 Inhibitor, in a First-in-Human, Single- and Multiple-Dose Study in Healthy Volunteers

Clinical drug investigation, 2019-09, Vol.39 (9), p.873-887

2019

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The role of P-glycoprotein in the bioactivation of raloxifene

Drug metabolism and disposition, 2006-12, Vol.34 (12), p.2073-2078

2006

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Differential effects of Rifampin and Ketoconazole on the blood and liver concentration of atorvastatin in wild-type and Cyp3a and Oatp1a/b knockout mice

Drug metabolism and disposition, 2014-06, Vol.42 (6), p.1067-1073

2014

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Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain

Journal of medicinal chemistry, 2019-04, Vol.62 (8), p.4091-4109

2019

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Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310

Journal of medicinal chemistry, 2021-03, Vol.64 (6), p.2953-2966

2021

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Rifampin-Mediated Induction of Tamoxifen Metabolism in a Humanized PXR-CAR-CYP3A4/3A7-CYP2D6 Mouse Model

Drug metabolism and disposition, 2016-11, Vol.44 (11), p.1736-1741

2016

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Unremarkable impact of Oatp inhibition on the liver concentration of fluvastatin, lovastatin and pitavastatin in wild-type and Oatp1a/1b knockout mouse

Xenobiotica, 2019-05, Vol.49 (5), p.602-610

2019

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Selective NaV1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain

Cell reports (Cambridge), 2018-09, Vol.24 (12), p.3133-3145

2018

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Discovery of 5‑Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability

Journal of medicinal chemistry, 2017-05, Vol.60 (10), p.4458-4473

2017

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Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927

Bioorganic & medicinal chemistry letters, 2019-08, Vol.29 (16), p.2090-2093

2019

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Evaluating the In Vitro Inhibition of UGT1A1, OATP1B1, OATP1B3, MRP2, and BSEP in Predicting Drug-Induced Hyperbilirubinemia

Applying Stable Isotope Labeled Amino Acids in Micropatterned Hepatocyte Coculture to Directly Determine the Degradation Rate Constant for CYP3A4

Comprehensive Evaluation of Bile Acid Homeostasis in Human Hepatocyte Co-Culture in the Presence of Troglitazone, Pioglitazone, and Acetylsalicylic Acid

Insensitivity to Pain upon Adult-Onset Deletion of Nav1.7 or Its Blockade with Selective Inhibitors

Unequal Absorption of Radiolabeled and Nonradiolabeled Drug from the Oral Dose Leads to Incorrect Estimates of Drug Absorption and Circulating Metabolites in a Mass Balance Study

Evaluation of a Competitive Equilibrium Dialysis Approach for Assessing the Impact of Protein Binding on Clearance Predictions

Sequential double-guidewire technique and transpancreatic precut sphincterotomy for difficult biliary cannulation

GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer

Investigating the Utility of Humanized Pregnane X Receptor-Constitutive Androstane Receptor-CYP3A4/7 Mouse Model to Assess CYP3A-Mediated Induction

The Role of pH in the Glucuronidation of Raloxifene, Mycophenolic Acid and Ezetimibe

Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production

Investigating the Impact of Albumin on the Liver Uptake of Pitavastatin and Warfarin in Nagase Analbuminemic Rats

Analysis of the bile acid composition in a fibroblast growth factor 19-expressing liver-humanized mouse model and its use for CYP3A4-mediated drug-drug interaction studies

Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma

Repeat kidney transplant recipients with active rejection have elevated donor‐derived cell‐free DNA

Safety, Tolerability, and Pharmacokinetics of GDC-0276, a Novel NaV1.7 Inhibitor, in a First-in-Human, Single- and Multiple-Dose Study in Healthy Volunteers

The role of P-glycoprotein in the bioactivation of raloxifene

Differential effects of Rifampin and Ketoconazole on the blood and liver concentration of atorvastatin in wild-type and Cyp3a and Oatp1a/b knockout mice

Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain

Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310

Rifampin-Mediated Induction of Tamoxifen Metabolism in a Humanized PXR-CAR-CYP3A4/3A7-CYP2D6 Mouse Model

Unremarkable impact of Oatp inhibition on the liver concentration of fluvastatin, lovastatin and pitavastatin in wild-type and Oatp1a/1b knockout mouse

Selective NaV1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain

Discovery of 5‑Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability

Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927

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