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Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs

Nature structural & molecular biology, 2014-09, Vol.21 (9), p.803-809

2014

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p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates

Proceedings of the National Academy of Sciences - PNAS, 2017-04, Vol.114 (14), p.3565-3571

2017

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Cereblon modulators: Low molecular weight inducers of protein degradation

Drug discovery today. Technologies, 2019-04, Vol.31, p.29-34

2019

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A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase

Nature (London), 2016-06, Vol.535 (7611), p.252-257

2016

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Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity

British journal of haematology, 2014-01, Vol.164 (2), p.233-244

2014

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A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase

Nature (London), 2016-07, Vol.535 (7611), p.252-257

2016

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A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos

Journal of medicinal chemistry, 2018-01, Vol.61 (2), p.535-542

2018

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Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

Nature (London), 2015-07, Vol.523 (7559), p.183-188

2015

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Inhibition of Human Telomerase by a G-Quadruplex-Interactive Compound

Journal of medicinal chemistry, 1997-07, Vol.40 (14), p.2113-2116

1997

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CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia

Journal of medicinal chemistry, 2021-02, Vol.64 (4), p.1835-1843

2021

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Increased hemoglobin affinity for oxygen with GBT1118 improves hypoxia tolerance in sickle cell mice

American journal of physiology. Heart and circulatory physiology, 2021-08, Vol.321 (2), p.H400-H411

2021

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GBT021601 improves red blood cell health and the pathophysiology of sickle cell disease in a murine model

British journal of haematology, 2023-07, Vol.202 (1), p.173-183

2023

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Pomalidomide in combination with dexamethasone results in synergistic anti‐tumour responses in pre‐clinical models of lenalidomide‐resistant multiple myeloma

British journal of haematology, 2016-03, Vol.172 (6), p.889-901

2016

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Discovery of the Selective Protein Kinase C-θ Kinase Inhibitor, CC-90005

Journal of medicinal chemistry, 2021-08, Vol.64 (16), p.11886-11903

2021

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CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization

Molecular cancer therapeutics, 2015-06, Vol.14 (6), p.1295-1305

2015

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Substrate Recognition and Ubiquitination of SCFSkp2/Cks1 Ubiquitin-Protein Isopeptide Ligase

The Journal of biological chemistry, 2007-05, Vol.282 (21), p.15462-15470

2007

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Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor

Bioorganic & medicinal chemistry letters, 2012-02, Vol.22 (3), p.1433-1438

2012

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Discovery of Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor CC-223

Journal of medicinal chemistry, 2015-07, Vol.58 (13), p.5323-5333

2015

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Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury

Bioorganic & medicinal chemistry letters, 2012-02, Vol.22 (3), p.1427-1432

2012

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Increased Hemoglobin Affinity for Oxygen with GBT021601 Reduces Pulmonary Hypertension and Lung Vascular Inflammation in a Murine Model of Sickle Cell Disease

Blood, 2022-11, Vol.140 (Supplement 1), p.5375-5376

2022

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GBT021601 Prevents Microvascular Dysfunction and Improves Hypoxia-Reoxygenation-Induced Vaso-Occlusion in a Murine Model of Sickle Cell Disease

Blood, 2022-11, Vol.140 (Supplement 1), p.5377-5378

2022

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GBT021601 Inhibits HbS Polymerization, Prevents RBC Sickling and Improves the Pathophysiology of Sickle Cell Disease in a Murine Model

Blood, 2020-11, Vol.136 (Supplement 1), p.7-8

2020

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Cellular transformation of the investigational new anticancer drug NB1011, a phosphoramidate of 5-(2-bromovinyl)-2′-deoxyuridine, results in modification of cellular proteins not DNA

Biochemical pharmacology, 2003-03, Vol.65 (5), p.823-831

2003

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CC-90009, a Novel Cereblon E3 Ligase Modulator, Targets GSPT1 for Degradation to Induce Potent Tumoricidal Activity Against Acute Myeloid Leukemia (AML)

Blood, 2019-11, Vol.134 (Supplement_1), p.2703-2703

2019

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Kinetic properties of human thymidylate synthase, an anticancer drug target

Biochemical and biophysical research communications, 2003-07, Vol.307 (2), p.297-300

2003

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Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs

p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates

Cereblon modulators: Low molecular weight inducers of protein degradation

A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase

Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase

A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos

Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

Inhibition of Human Telomerase by a G-Quadruplex-Interactive Compound

CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia

Increased hemoglobin affinity for oxygen with GBT1118 improves hypoxia tolerance in sickle cell mice

GBT021601 improves red blood cell health and the pathophysiology of sickle cell disease in a murine model

Pomalidomide in combination with dexamethasone results in synergistic anti‐tumour responses in pre‐clinical models of lenalidomide‐resistant multiple myeloma

Discovery of the Selective Protein Kinase C-θ Kinase Inhibitor, CC-90005

CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization

Substrate Recognition and Ubiquitination of SCFSkp2/Cks1 Ubiquitin-Protein Isopeptide Ligase

Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor

Discovery of Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor CC-223

Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury

Increased Hemoglobin Affinity for Oxygen with GBT021601 Reduces Pulmonary Hypertension and Lung Vascular Inflammation in a Murine Model of Sickle Cell Disease

GBT021601 Prevents Microvascular Dysfunction and Improves Hypoxia-Reoxygenation-Induced Vaso-Occlusion in a Murine Model of Sickle Cell Disease

GBT021601 Inhibits HbS Polymerization, Prevents RBC Sickling and Improves the Pathophysiology of Sickle Cell Disease in a Murine Model

Cellular transformation of the investigational new anticancer drug NB1011, a phosphoramidate of 5-(2-bromovinyl)-2′-deoxyuridine, results in modification of cellular proteins not DNA

CC-90009, a Novel Cereblon E3 Ligase Modulator, Targets GSPT1 for Degradation to Induce Potent Tumoricidal Activity Against Acute Myeloid Leukemia (AML)

Kinetic properties of human thymidylate synthase, an anticancer drug target

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