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Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2)

Journal of medicinal chemistry, 2015-09, Vol.58 (18), p.7173-7185

2015

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N → N’ acyl migration in the context of a medicinal chemistry program

Tetrahedron, 2022-09, Vol.123, p.132950, Article 132950

2022

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Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing

Journal of the American Chemical Society, 2020-05, Vol.142 (19), p.8706-8727

2020

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Route Optimization of the Non-covalent Modulator of Hemoglobin PF-07059013 for the Treatment of Sickle Cell Disease, Part I: From Discovery Synthesis to First Kilogram-Scale Manufacture

Organic process research & development, 2023-05, Vol.27 (5), p.854-865

2023

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Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting

Journal of medicinal chemistry, 2020-10, Vol.63 (19), p.10879-10896

2020

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PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease

Journal of medicinal chemistry, 2021-01, Vol.64 (1), p.326-342

2021

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Development of an O-Vinylation–Ring-Closing Metathesis Strategy to Access 3,3′-3,4-Dihydropyrans

Synlett, 2016-11, Vol.27 (18), p.2611-2615

2016

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Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5)

Scientific reports, 2015-12, Vol.5 (1), p.17391-17391, Article 17391

2015

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Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family

Journal of medicinal chemistry, 2016-02, Vol.59 (3), p.1165-1175

2016

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The Synthesis of Methyl-Substituted Spirocyclic Piperidine-Azetidine (2,7-Diazaspiro[3.5]nonane) and Spirocyclic Piperidine-Pyrrolidine (2,8-Diazaspiro[4.5]decane) Ring Systems

Journal of organic chemistry, 2016-05, Vol.81 (9), p.3509-3519

2016

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Lithium borohydride: a reagent of choice for the selective reductive amination of cyclohexanones

Tetrahedron letters, 2007-10, Vol.48 (40), p.7134-7136

2007

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Route Selection and Optimization in the Synthesis of Two Imidazopyridine Inhibitors of DGAT‑2

Organic process research & development, 2018-03, Vol.22 (3), p.360-367

2018

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Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5′-Adenosine Monophosphate-Activated Protein Kinase (AMPK)

Journal of medicinal chemistry, 2018-03, Vol.61 (6), p.2372-2383

2018

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Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase

Bioorganic & medicinal chemistry letters, 2015-11, Vol.25 (22), p.5352-5356

2015

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Development of a selective activity-based probe for glycosylated LIPA

Bioorganic & medicinal chemistry letters, 2016-04, Vol.26 (8), p.1993-1996

2016

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Evolution of the Synthesis of AMPK Activators for the Treatment of Diabetic Nephropathy: From Three Preclinical Candidates to the Investigational New Drug PF-06409577

Organic process research & development, 2018-06, Vol.22 (6), p.681-696

2018

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Reactive metabolite trapping studies on imidazo- and 2-methylimidazo[2,1-b]thiazole-based inverse agonists of the ghrelin receptor

Drug metabolism and disposition, 2013-07, Vol.41 (7), p.1375-1388

2013

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Synthesis of 7-Oxo-dihydrospiro[indazole-5,4′-piperidine] Acetyl-CoA Carboxylase Inhibitors

Journal of organic chemistry, 2012-02, Vol.77 (3), p.1497-1506

2012

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Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor

Bioorganic & medicinal chemistry letters, 2012-07, Vol.22 (13), p.4281-4287

2012

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One-pot synthesis of chiral azetidines from chloroaldehyde and chiral amines

Tetrahedron letters, 2011-07, Vol.52 (28), p.3618-3620

2011

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Synthesis of 7-Oxo-dihydrospiro[indazole-5,4'-piperidinel Acetyl-CoA Carboxylase Inhibitors

Journal of organic chemistry, 2012, Vol.77 (3), p.1497-1506

2012

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Chemical Probe Identification Platform for Orphan GPCRs Using Focused Compound Screening: GPR39 as a Case Example

ACS medicinal chemistry letters, 2013-11, Vol.4 (11), p.1079-1084

2013

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New fluorinated pyrrolidine and azetidine amides as dipeptidyl peptidase IV inhibitors

Bioorganic & medicinal chemistry letters, 2005-11, Vol.15 (21), p.4770-4773

2005

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Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms

Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2)

N → N’ acyl migration in the context of a medicinal chemistry program

Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing

Route Optimization of the Non-covalent Modulator of Hemoglobin PF-07059013 for the Treatment of Sickle Cell Disease, Part I: From Discovery Synthesis to First Kilogram-Scale Manufacture

Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting

Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis

PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease

Development of an O-Vinylation–Ring-Closing Metathesis Strategy to Access 3,3′-3,4-Dihydropyrans

Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5)

Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family

The Synthesis of Methyl-Substituted Spirocyclic Piperidine-Azetidine (2,7-Diazaspiro[3.5]nonane) and Spirocyclic Piperidine-Pyrrolidine (2,8-Diazaspiro[4.5]decane) Ring Systems

Lithium borohydride: a reagent of choice for the selective reductive amination of cyclohexanones

Route Selection and Optimization in the Synthesis of Two Imidazopyridine Inhibitors of DGAT‑2

Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5′-Adenosine Monophosphate-Activated Protein Kinase (AMPK)

Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase

Development of a selective activity-based probe for glycosylated LIPA

Evolution of the Synthesis of AMPK Activators for the Treatment of Diabetic Nephropathy: From Three Preclinical Candidates to the Investigational New Drug PF-06409577

Reactive metabolite trapping studies on imidazo- and 2-methylimidazo[2,1-b]thiazole-based inverse agonists of the ghrelin receptor

Synthesis of 7-Oxo-dihydrospiro[indazole-5,4′-piperidine] Acetyl-CoA Carboxylase Inhibitors

Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor

One-pot synthesis of chiral azetidines from chloroaldehyde and chiral amines

Synthesis of 7-Oxo-dihydrospiro[indazole-5,4'-piperidinel Acetyl-CoA Carboxylase Inhibitors

Chemical Probe Identification Platform for Orphan GPCRs Using Focused Compound Screening: GPR39 as a Case Example

New fluorinated pyrrolidine and azetidine amides as dipeptidyl peptidase IV inhibitors

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