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Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions

Science (American Association for the Advancement of Science), 2014-11, Vol.346 (6210), p.759-763

2014

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Soluble CD4 and CD4-mimetic compounds inhibit HIV-1 infection by induction of a short-lived activated state

PLoS pathogens, 2009-04, Vol.5 (4), p.e1000360-e1000360

2009

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Contribution of intrinsic reactivity of the HIV-1 envelope glycoproteins to CD4-independent infection and global inhibitor sensitivity

PLoS pathogens, 2011-06, Vol.7 (6), p.e1002101-e1002101

2011

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Structure-Based Design, Synthesis and Validation of CD4-Mimetic Small Molecule Inhibitors of HIV‑1 Entry: Conversion of a Viral Entry Agonist to an Antagonist

Accounts of chemical research, 2014-04, Vol.47 (4), p.1228-1237

2014

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Crystal structures of HIV-1 gp120 envelope glycoprotein in complex with NBD analogues that target the CD4-binding site

PloS one, 2014-01, Vol.9 (1), p.e85940

2014

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Structure-Based Design, Synthesis, and Characterization of Dual Hotspot Small-Molecule HIV-1 Entry Inhibitors

Journal of medicinal chemistry, 2012-05, Vol.55 (9), p.4382-4396

2012

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Nonequilibrium dynamics of helix reorganization observed by transient 2D IR spectroscopy

Proceedings of the National Academy of Sciences - PNAS, 2013-10, Vol.110 (43), p.17314-17319

2013

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Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV‑1 Entry Inhibition

ACS medicinal chemistry letters, 2016-03, Vol.7 (3), p.330-334

2016

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CD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodies

Journal of virology, 2014-06, Vol.88 (12), p.6542-6555

2014

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Antibody-Dependent Cellular Cytotoxicity against Reactivated HIV-1-Infected Cells

Journal of virology, 2016-02, Vol.90 (4), p.2021-2030

2016

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An inducible cell-cell fusion system with integrated ability to measure the efficiency and specificity of HIV-1 entry inhibitors

PloS one, 2011-11, Vol.6 (11), p.e26731-e26731

2011

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Structure-activity relationships of tubulysin analogues

Bioorganic & medicinal chemistry letters, 2020-07, Vol.30 (14), p.127241-127241, Article 127241

2020

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Tetrazine Phototriggers: Probes for Peptide Dynamics

Angewandte Chemie (International ed.), 2010-05, Vol.49 (21), p.3612-3616

2010

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Small CD4 Mimetics Prevent HIV-1 Uninfected Bystander CD4+ T Cell Killing Mediated by Antibody-dependent Cell-mediated Cytotoxicity

EBioMedicine, 2016-01, Vol.3 (C), p.122-134

2016

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Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening

Bioorganic & medicinal chemistry, 2011-01, Vol.19 (1), p.91-101

2011

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Small-Molecule CD4 Mimics Interact with a Highly Conserved Pocket on HIV-1 gp120

Structure (London), 2008-11, Vol.16 (11), p.1689-1701

2008

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CD4 mimetics sensitize HIV-1-infected cells to ADCC

Proceedings of the National Academy of Sciences - PNAS, 2015-05, Vol.112 (20), p.E2687-E2694

2015

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Structure-Based Design and Synthesis of an HIV‑1 Entry Inhibitor Exploiting X‑ray and Thermodynamic Characterization

ACS medicinal chemistry letters, 2013-03, Vol.4 (3), p.338-343

2013

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Identification of a Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Variant Resistant to Cold Inactivation

Journal of Virology, 2009-05, Vol.83 (9), p.4476-4488

2009

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The Design and Synthesis of Alanine-Rich α‑Helical Peptides Constrained by an S,S‑Tetrazine Photochemical Trigger: A Fragment Union Approach

Journal of organic chemistry, 2014-01, Vol.79 (2), p.759-768

2014

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Design, Synthesis, and Photochemical Validation of Peptide Linchpins Containing the S,S-Tetrazine Phototrigger

Organic letters, 2012-07, Vol.14 (13), p.3518-3521

2012

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Di-cysteine S,S-tetrazine: A potential ultra-fast photochemical trigger to explore the early events of peptide/protein folding

Journal of photochemistry and photobiology. A, Chemistry., 2012-04, Vol.234, p.156-163

2012

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Transitions to and from the CD4-Bound Conformation Are Modulated by a Single-Residue Change in the Human Immunodeficiency Virus Type 1 gp120 Inner Domain

Journal of Virology, 2009-09, Vol.83 (17), p.8364-8378

2009

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Conformational and Structural Features of HIV-1 gp120 Underlying the Dual Receptor Antagonism by Cross-Reactive Neutralizing Antibody m18

Biochemistry (Easton), 2011-04, Vol.50 (14), p.2756-2768

2011

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Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions

Soluble CD4 and CD4-mimetic compounds inhibit HIV-1 infection by induction of a short-lived activated state

Contribution of intrinsic reactivity of the HIV-1 envelope glycoproteins to CD4-independent infection and global inhibitor sensitivity

Structure-Based Design, Synthesis and Validation of CD4-Mimetic Small Molecule Inhibitors of HIV‑1 Entry: Conversion of a Viral Entry Agonist to an Antagonist

Crystal structures of HIV-1 gp120 envelope glycoprotein in complex with NBD analogues that target the CD4-binding site

Structure-Based Design, Synthesis, and Characterization of Dual Hotspot Small-Molecule HIV-1 Entry Inhibitors

Nonequilibrium dynamics of helix reorganization observed by transient 2D IR spectroscopy

Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV‑1 Entry Inhibition

Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins

CD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodies

Antibody-Dependent Cellular Cytotoxicity against Reactivated HIV-1-Infected Cells

An inducible cell-cell fusion system with integrated ability to measure the efficiency and specificity of HIV-1 entry inhibitors

Structure-activity relationships of tubulysin analogues

Tetrazine Phototriggers: Probes for Peptide Dynamics

Small CD4 Mimetics Prevent HIV-1 Uninfected Bystander CD4+ T Cell Killing Mediated by Antibody-dependent Cell-mediated Cytotoxicity

Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening

Small-Molecule CD4 Mimics Interact with a Highly Conserved Pocket on HIV-1 gp120

CD4 mimetics sensitize HIV-1-infected cells to ADCC

Structure-Based Design and Synthesis of an HIV‑1 Entry Inhibitor Exploiting X‑ray and Thermodynamic Characterization

Identification of a Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Variant Resistant to Cold Inactivation

The Design and Synthesis of Alanine-Rich α‑Helical Peptides Constrained by an S,S‑Tetrazine Photochemical Trigger: A Fragment Union Approach

Design, Synthesis, and Photochemical Validation of Peptide Linchpins Containing the S,S-Tetrazine Phototrigger

Di-cysteine S,S-tetrazine: A potential ultra-fast photochemical trigger to explore the early events of peptide/protein folding

Transitions to and from the CD4-Bound Conformation Are Modulated by a Single-Residue Change in the Human Immunodeficiency Virus Type 1 gp120 Inner Domain

Conformational and Structural Features of HIV-1 gp120 Underlying the Dual Receptor Antagonism by Cross-Reactive Neutralizing Antibody m18

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