UB Paderborn / Katalog / Suche / in CDI

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

Cell, 2016-06, Vol.166 (1), p.193-208

2016

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Treatment strategies targeting amyloid β-protein

Cold Spring Harbor perspectives in medicine, 2012-09, Vol.2 (9), p.a006387-a006387

2012

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Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System

The Journal of biological chemistry, 2009-01, Vol.284 (5), p.2598-2602

2009

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Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies

Alzheimer's research & therapy, 2011-09, Vol.3 (5), p.28-28

2011

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Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region

The Journal of biological chemistry, 2011-11, Vol.286 (46), p.39804-39812

2011

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Amyloid β-Protein Precursor Juxtamembrane Domain Regulates Specificity of γ-Secretase-dependent Cleavages

The Journal of biological chemistry, 2007-11, Vol.282 (48), p.35350-35360

2007

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Purification and cloning of amyloid precursor protein β-secretase from human brain

Nature (London), 1999-12, Vol.402 (6761), p.537-540

1999

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Evidence that enzyme processivity mediates differential Aβ production by PS1 and PS2

Current Alzheimer research, 2013-01, Vol.10 (1), p.4

2013

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Crystal structure reveals conservation of amyloid-β conformation recognized by 3D6 following humanization to bapineuzumab

Alzheimer's research & therapy, 2014-01, Vol.6 (3), p.31-31

2014

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Discovery of (R)‑4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro‑1H‑pyrazolo[4,3‑c]quinoline (ELND006) and (R)‑4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro‑2H‑pyrazolo[4,3‑c]quinoline (ELND007): Metabolically Stable γ‑Secretase Inhibitors that Selectively Inhibit the Production of Amyloid‑β over Notch

Journal of medicinal chemistry, 2013-07, Vol.56 (13), p.5261-5274

2013

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Structural Correlates of Antibodies Associated with Acute Reversal of Amyloid β-related Behavioral Deficits in a Mouse Model of Alzheimer Disease

The Journal of biological chemistry, 2010-01, Vol.285 (5), p.3417-3427

2010

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Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (4), p.996-1000

2013

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Discovery of sulfonamide–pyrazole γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (7), p.2148-2150

2010

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Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease

Alzheimer's research & therapy, 2010-12, Vol.2 (6), p.36-36

2010

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Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and Efficacious γ-Secretase Inhibitors

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (7), p.2195-2199

2010

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Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious γ-secretase inhibitors (Part II)

Bioorganic & medicinal chemistry letters, 2010-06, Vol.20 (12), p.3502-3506

2010

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N-Bridged bicyclic sulfonamides as inhibitors of γ-secretase

Bioorganic & medicinal chemistry letters, 2009-12, Vol.19 (24), p.6952-6956

2009

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Immunotherapy reduces vascular amyloid-beta in PDAPP mice

The Journal of neuroscience, 2008-07, Vol.28 (27), p.6787-6793

2008

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Pharmacokinetic and pharmacodynamic analysis of a novel gamma secretase inhibitor in a nontransgenic A-beta mouse efficacy model

Alzheimer's & dementia, 2009-07, Vol.5 (4), p.P437-P437

2009

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Pharmacokinetic and pharmacodynamic analysis of a novel gamma secretase inhibitor in a non-transgenic A-beta mouse efficacy model

Alzheimer's & dementia, 2009-07, Vol.5 (4), p.P182-P182

2009

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Identification of γ-Secretase Inhibitor Potency Determinants on Presenilin

The Journal of biological chemistry, 2008-02, Vol.283 (5), p.2927-2938

2008

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Caspase-mediated Cleavage of DNA Topoisomerase I at Unconventional Sites during Apoptosis

The Journal of biological chemistry, 1999-02, Vol.274 (7), p.4335-4340

1999

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Discovery of ( R )-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1 H -pyrazolo[4,3- c ]quinoline (ELND006) and ( R )-4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2 H -pyrazolo[4,3- c ]quinoline (ELND007): Metabolically Stable γ-Secretase Inhibitors that Selectively Inhibit the Production of Amyloid-β over Notch

Journal of medicinal chemistry, 2013-07, Vol.56 (13), p.5261-5274

2013

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Antagonistic Effects of β-Site Amyloid Precursor Protein-cleaving Enzymes 1 and 2 on β-Amyloid Peptide Production in Cells

The Journal of biological chemistry, 2003-08, Vol.278 (34), p.31512-31520

2003

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Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

Treatment strategies targeting amyloid β-protein

Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System

Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies

Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region

Amyloid β-Protein Precursor Juxtamembrane Domain Regulates Specificity of γ-Secretase-dependent Cleavages

Purification and cloning of amyloid precursor protein β-secretase from human brain

Evidence that enzyme processivity mediates differential Aβ production by PS1 and PS2

Crystal structure reveals conservation of amyloid-β conformation recognized by 3D6 following humanization to bapineuzumab

Structural Correlates of Antibodies Associated with Acute Reversal of Amyloid β-related Behavioral Deficits in a Mouse Model of Alzheimer Disease

Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors

Discovery of sulfonamide–pyrazole γ-secretase inhibitors

Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease

Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and Efficacious γ-Secretase Inhibitors

Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious γ-secretase inhibitors (Part II)

N-Bridged bicyclic sulfonamides as inhibitors of γ-secretase

Immunotherapy reduces vascular amyloid-beta in PDAPP mice

Pharmacokinetic and pharmacodynamic analysis of a novel gamma secretase inhibitor in a nontransgenic A-beta mouse efficacy model

Pharmacokinetic and pharmacodynamic analysis of a novel gamma secretase inhibitor in a non-transgenic A-beta mouse efficacy model

Identification of γ-Secretase Inhibitor Potency Determinants on Presenilin

Caspase-mediated Cleavage of DNA Topoisomerase I at Unconventional Sites during Apoptosis

BACE knockout mice are healthy despite lacking the primary β-secretase activity in brain: implications for Alzheimer's disease therapeutics

Antagonistic Effects of β-Site Amyloid Precursor Protein-cleaving Enzymes 1 and 2 on β-Amyloid Peptide Production in Cells

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