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Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-( N, N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor

Bioorganic & medicinal chemistry letters, 2009-04, Vol.19 (8), p.2179-2185

2009

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Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model

Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (21), p.6231-6236

2010

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Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (6), p.1838-1843

2011

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Design and synthesis of cell potent BACE-1 inhibitors: Structure–activity relationship of P1′ substituents

Bioorganic & medicinal chemistry letters, 2009-11, Vol.19 (22), p.6386-6391

2009

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Ruthenium-Catalyzed Alder Ene Type Reactions. A Formal Synthesis of Alternaric Acid

Journal of the American Chemical Society, 1998-09, Vol.120 (36), p.9228-9236

1998

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Novel cinnoline-based inhibitors of LRRK2 kinase activity

Bioorganic & medicinal chemistry letters, 2013-01, Vol.23 (1), p.71-74

2013

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Triazolopyridazine LRRK2 kinase inhibitors

Bioorganic & medicinal chemistry letters, 2013-04, Vol.23 (7), p.1967-1973

2013

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Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors

Bioorganic & medicinal chemistry letters, 2013-04, Vol.23 (7), p.1974-1977

2013

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A Formal Synthesis of (−)-Mycalamide A

Journal of the American Chemical Society, 2004-01, Vol.126 (1), p.48-49

2004

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Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Prime side chromane-containing inhibitors

Bioorganic & medicinal chemistry letters, 2013-08, Vol.23 (16), p.4674-4679

2013

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Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration

Bioorganic & medicinal chemistry letters, 2011-09, Vol.21 (18), p.5521-5527

2011

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Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (1), p.315-319

2011

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Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates

Bioorganic & medicinal chemistry letters, 2013-04, Vol.23 (7), p.2181-2186

2013

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Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (4), p.996-1000

2013

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Design, synthesis, and structure–activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (17), p.4920-4923

2009

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Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (24), p.7303-7307

2010

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Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: Structure–activity relationship of P2′ substituents

Bioorganic & medicinal chemistry letters, 2010-08, Vol.20 (16), p.4789-4794

2010

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Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Structure–activity relationship of the aryl region

Bioorganic & medicinal chemistry letters, 2010-10, Vol.20 (20), p.6034-6039

2010

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Design, synthesis and structure–activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2011-10, Vol.21 (19), p.5791-5794

2011

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N-Bridged bicyclic sulfonamides as inhibitors of γ-secretase

Bioorganic & medicinal chemistry letters, 2009-12, Vol.19 (24), p.6952-6956

2009

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Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious [gamma]-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (4), p.996-1000

2013

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Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent [gamma]-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2011-10, Vol.21 (19), p.5791-5794

2011

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Highly selective c-Jun N-terminal kinase UNK 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration

Bioorganic & medicinal chemistry letters, 2011, Vol.21 (1), p.315-319

2011

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Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline g-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (17), p.4920-4923

2009

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Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-( N, N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor

Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model

Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor

Design and synthesis of cell potent BACE-1 inhibitors: Structure–activity relationship of P1′ substituents

Ruthenium-Catalyzed Alder Ene Type Reactions. A Formal Synthesis of Alternaric Acid

Novel cinnoline-based inhibitors of LRRK2 kinase activity

Triazolopyridazine LRRK2 kinase inhibitors

Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors

A Formal Synthesis of (−)-Mycalamide A

Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Prime side chromane-containing inhibitors

Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration

Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration

Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates

Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors

Design, synthesis, and structure–activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline γ-secretase inhibitors

Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK

Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: Structure–activity relationship of P2′ substituents

Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Structure–activity relationship of the aryl region

Design, synthesis and structure–activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors

N-Bridged bicyclic sulfonamides as inhibitors of γ-secretase

Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious [gamma]-secretase inhibitors

Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent [gamma]-secretase inhibitors

Highly selective c-Jun N-terminal kinase UNK 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration

Corrigendum to “Design, synthesis, and structure–activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline γ-secretase inhibitors” [Bioorg. Med. Chem. Lett. 19 (2009) 4920]

Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline g-secretase inhibitors

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