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Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism

Nature communications, 2023-05, Vol.14 (1), p.2847-2847, Article 2847

2023

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Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface

eLife, 2020-07, Vol.9

2020

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Trafficking, a key player in regulated intramembrane proteolysis

Seminars in cell & developmental biology, 2009-04, Vol.20 (2), p.183-190

2009

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ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

Proceedings of the National Academy of Sciences - PNAS, 2011-08, Vol.108 (34), p.E559-E568

2011

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A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency

Scientific reports, 2017-01, Vol.7 (1), p.41408-41408, Article 41408

2017

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The PIKfyve complex regulates the early melanosome homeostasis required for physiological amyloid formation

Journal of cell science, 2019-02, Vol.132 (5)

2019

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Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments

Molecular neurodegeneration, 2017-03, Vol.12 (1), p.25-25, Article 25

2017

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Inhomogeneity Based Characterization of Distribution Patterns on the Plasma Membrane

PLoS computational biology, 2016-09, Vol.12 (9), p.e1005095-e1005095

2016

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Endosome to trans-Golgi network transport of Proprotein Convertase 7 is mediated by a cluster of basic amino acids and palmitoylated cysteines

European journal of cell biology, 2017-08, Vol.96 (5), p.432-439

2017

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A fast growing spectrum of biological functions of γ-secretase in development and disease

Biochimica et biophysica acta, 2013-12, Vol.1828 (12), p.2815-2827

2013

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Contribution of the Presenilins in the cell biology, structure and function of γ-secretase

Seminars in cell & developmental biology, 2020-09, Vol.105, p.12-26

2020

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Retrograde traffic in the biosynthetic-secretory route: pathways and machinery

Current opinion in cell biology, 2003-08, Vol.15 (4), p.438-445

2003

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Bin1 and CD2AP polarize Aβ generation in neurons

EMBO reports, 2017-01, Vol.18 (1), p.5-7

2017

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Bin1 and CD2AP polarize A[beta] generation in neurons

EMBO reports, 2017-01, Vol.18 (1), p.5

2017

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Elucidating the molecular basis of altered Presenilin 2 expression on Alzheimer’s disease pathology

Alzheimer's & dementia, 2022-12, Vol.18 (S3), p.n/a

2022

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Contribution of Alzheimer’s disease risk genes in the maintenance of endolysosomal transport regulation: Molecular and cell biology/endosomal‐lysosomal dysfunction

Alzheimer's & dementia, 2020-12, Vol.16 (S2)

2020

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Contribution of Alzheimer’s disease risk genes in the maintenance of endolysosomal transport regulation

Alzheimer's & dementia, 2020-12, Vol.16, p.n/a

2020

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Altered PLD3 exonuclease activity impacts on lysosomal and mitochondrial homeostasis

Alzheimer's & dementia, 2022-12, Vol.18 (S4), p.n/a

2022

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PIKfyve activity regulates reformation of terminal storage lysosomes from endolysosomes

Traffic (Copenhagen, Denmark), 2017-11, Vol.18 (11), p.747-757

2017

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ATP13A3 is a major component of the enigmatic mammalian polyamine transport system

The Journal of biological chemistry, 2021-01, Vol.296, p.100182, Article 100182

2021

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Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum

The Journal of cell biology, 2021-09, Vol.220 (9), p.1

2021

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Deficiency of the lysosomal exonuclease PLD3 impacts the degradative route

Alzheimer's & dementia, 2021-12, Vol.17 (S3), p.e050868-n/a

2021

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Accumulation of APP C-terminal fragments causes endolysosomal dysfunction through the dysregulation of late endosome to lysosome-ER contact sites

Developmental cell, 2024-06, Vol.59 (12), p.1571-1592.e9

2024

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Contribution of Alzheimer’s disease risk genes in the maintenance of endolysosomal transport regulation

Alzheimer's & dementia, 2021-12, Vol.17, p.e053723-n/a

2021

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Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism

Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface

Trafficking, a key player in regulated intramembrane proteolysis

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency

The PIKfyve complex regulates the early melanosome homeostasis required for physiological amyloid formation

Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments

Inhomogeneity Based Characterization of Distribution Patterns on the Plasma Membrane

Endosome to trans-Golgi network transport of Proprotein Convertase 7 is mediated by a cluster of basic amino acids and palmitoylated cysteines

A fast growing spectrum of biological functions of γ-secretase in development and disease

Contribution of the Presenilins in the cell biology, structure and function of γ-secretase

Retrograde traffic in the biosynthetic-secretory route: pathways and machinery

Bin1 and CD2AP polarize Aβ generation in neurons

Bin1 and CD2AP polarize A[beta] generation in neurons

Elucidating the molecular basis of altered Presenilin 2 expression on Alzheimer’s disease pathology

Contribution of Alzheimer’s disease risk genes in the maintenance of endolysosomal transport regulation: Molecular and cell biology/endosomal‐lysosomal dysfunction

Contribution of Alzheimer’s disease risk genes in the maintenance of endolysosomal transport regulation

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

Altered PLD3 exonuclease activity impacts on lysosomal and mitochondrial homeostasis

PIKfyve activity regulates reformation of terminal storage lysosomes from endolysosomes

ATP13A3 is a major component of the enigmatic mammalian polyamine transport system

Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum

Deficiency of the lysosomal exonuclease PLD3 impacts the degradative route

Accumulation of APP C-terminal fragments causes endolysosomal dysfunction through the dysregulation of late endosome to lysosome-ER contact sites

Contribution of Alzheimer’s disease risk genes in the maintenance of endolysosomal transport regulation

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