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A specificity map for the PDZ domain family

PLoS biology, 2008-09, Vol.6 (9), p.e239-e239

2008

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Variants of the Antibody Herceptin That Interact with HER2 and VEGF at the Antigen Binding Site

Science (American Association for the Advancement of Science), 2009-03, Vol.323 (5921), p.1610-1614

2009

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A Structural Portrait of the PDZ Domain Family

Journal of molecular biology, 2014-10, Vol.426 (21), p.3509-3519

2014

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Discovery of Potent and Selective RSK Inhibitors as Biological Probes

Journal of medicinal chemistry, 2015-09, Vol.58 (17), p.6766-6783

2015

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Structure of IL-33 and Its Interaction with the ST2 and IL-1RAcP Receptors—Insight into Heterotrimeric IL-1 Signaling Complexes

Structure (London), 2009-10, Vol.17 (10), p.1398-1410

2009

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Inhibition of Wnt signaling by Dishevelled PDZ peptides

Nature chemical biology, 2009-04, Vol.5 (4), p.217-219

2009

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Design and Discovery of N‑(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic

Journal of medicinal chemistry, 2020-03, Vol.63 (5), p.2013-2027

2020

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Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers

Molecular cancer research, 2014-05, Vol.12 (5), p.803-812

2014

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Comprehensive Analysis of the Factors Contributing to the Stability and Solubility of Autonomous Human VH Domains

The Journal of biological chemistry, 2008-02, Vol.283 (6), p.3639-3654

2008

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A Drug Resistance Screen Using a Selective MET Inhibitor Reveals a Spectrum of Mutations That Partially Overlap with Activating Mutations Found in Cancer Patients

Cancer research (Chicago, Ill.), 2011-08, Vol.71 (15), p.5255-5264

2011

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The Crystal Structure of Murine Coronin-1: A Regulator of Actin Cytoskeletal Dynamics in Lymphocytes

Structure (London), 2006, Vol.14 (1), p.87-96

2006

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GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis

Science advances, 2021-10, Vol.7 (40), p.eabj2485-eabj2485

2021

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Discovery and Optimization of Phosphopantetheine Adenylyltransferase Inhibitors with Gram-Negative Antibacterial Activity

Journal of medicinal chemistry, 2018-04, Vol.61 (8), p.3325-3349

2018

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Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria

Journal of medicinal chemistry, 2018-04, Vol.61 (8), p.3309-3324

2018

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Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding

The EMBO journal, 2007-11, Vol.26 (23), p.4902-4912

2007

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Design and synthesis of potent RSK inhibitors

Bioorganic & medicinal chemistry letters, 2018-10, Vol.28 (19), p.3197-3201

2018

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Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3

Protein science, 2007-11, Vol.16 (11), p.2454-2471

2007

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Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma

ACS medicinal chemistry letters, 2015-09, Vol.6 (9), p.961-965

2015

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Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors

Bioorganic & medicinal chemistry letters, 2017-12, Vol.27 (23), p.5221-5224

2017

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Anakinra in the treatment of polyarticular-course juvenile rheumatoid arthritis: safety and preliminary efficacy results of a randomized multicenter study

Clinical rheumatology, 2009-02, Vol.28 (2), p.129-137

2009

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Convergent and Divergent Ligand Specificity among PDZ Domains of the LAP and Zonula Occludens (ZO) Families

The Journal of biological chemistry, 2006-08, Vol.281 (31), p.22299-22311

2006

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Structural and functional analysis of the ligand specificity of the HtrA2/Omi PDZ domain

Protein science, 2007-08, Vol.16 (8), p.1738-1750

2007

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2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors

Bioorganic & medicinal chemistry letters, 2014-03, Vol.24 (6), p.1592-1596

2014

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Perception of noxious and innocuous heat stimulation among healthy women and women with fibromyalgia: association with mood, somatic focus, and catastrophizing

Pain (Amsterdam), 2003-04, Vol.102 (3), p.243-250

2003

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Design and Discovery of N‑(2-Methyl-5′-morpholino-6′-((tetrahydro‑2H‑pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers

Journal of medicinal chemistry, 2017-06, Vol.60 (12), p.4869-4881

2017

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A specificity map for the PDZ domain family

Variants of the Antibody Herceptin That Interact with HER2 and VEGF at the Antigen Binding Site

A Structural Portrait of the PDZ Domain Family

Discovery of Potent and Selective RSK Inhibitors as Biological Probes

Structure of IL-33 and Its Interaction with the ST2 and IL-1RAcP Receptors—Insight into Heterotrimeric IL-1 Signaling Complexes

Inhibition of Wnt signaling by Dishevelled PDZ peptides

Design and Discovery of N‑(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic

Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers

Comprehensive Analysis of the Factors Contributing to the Stability and Solubility of Autonomous Human VH Domains

A Drug Resistance Screen Using a Selective MET Inhibitor Reveals a Spectrum of Mutations That Partially Overlap with Activating Mutations Found in Cancer Patients

The Crystal Structure of Murine Coronin-1: A Regulator of Actin Cytoskeletal Dynamics in Lymphocytes

GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis

Discovery and Optimization of Phosphopantetheine Adenylyltransferase Inhibitors with Gram-Negative Antibacterial Activity

Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria

Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding

Design and synthesis of potent RSK inhibitors

Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3

Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma

Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors

Anakinra in the treatment of polyarticular-course juvenile rheumatoid arthritis: safety and preliminary efficacy results of a randomized multicenter study

Convergent and Divergent Ligand Specificity among PDZ Domains of the LAP and Zonula Occludens (ZO) Families

Structural and functional analysis of the ligand specificity of the HtrA2/Omi PDZ domain

2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors

Perception of noxious and innocuous heat stimulation among healthy women and women with fibromyalgia: association with mood, somatic focus, and catastrophizing

Design and Discovery of N‑(2-Methyl-5′-morpholino-6′-((tetrahydro‑2H‑pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers

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