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Discovery of TRPM8 Antagonist (S)‑6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine

Journal of medicinal chemistry, 2018-09, Vol.61 (18), p.8186-8201

2018

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A Content Analysis of Coronavirus Tweets in the United States Just Prior to the Pandemic Declaration

Cyberpsychology, behavior and social networking, 2020-12, Vol.23 (12), p.889-893

2020

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College students' perceptions of COVID-19 conversations on social media

Journal of American college health, 2024, Vol.72 (1), p.166-176

2024

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Design, Optimization, and Biological Evaluation of Novel Keto-Benzimidazoles as Potent and Selective Inhibitors of Phosphodiesterase 10A (PDE10A)

Journal of medicinal chemistry, 2013-11, Vol.56 (21), p.8781-8792

2013

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Discovery of Clinical Candidate 1‑(4-(3-(4-(1H‑Benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), A Potent, Selective, and Efficacious Inhibitor of Phosphodiesterase 10A (PDE10A)

Journal of medicinal chemistry, 2014-08, Vol.57 (15), p.6632-6641

2014

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Identification of Antibody and Small Molecule Antagonists of Ferroportin-Hepcidin Interaction

Frontiers in pharmacology, 2017-11, Vol.8, p.838-838

2017

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Initial characterization of a PDE10A selective positron emission tomography tracer [11 C]AMG 7980 in non-human primates

Nuclear medicine and biology, 2014-04, Vol.41 (4), p.343-349

2014

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Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux

Bioorganic & medicinal chemistry letters, 2012-12, Vol.22 (24), p.7371-7375

2012

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Discovery of Potent, Orally Bioavailable Phthalazinone Bradykinin B1 Receptor Antagonists

Journal of medicinal chemistry, 2011-10, Vol.54 (20), p.7232-7246

2011

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Rapid Identification of a Novel Small Molecule Phosphodiesterase 10A (PDE10A) Tracer

Journal of medicinal chemistry, 2012-05, Vol.55 (10), p.4776-4787

2012

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Radiosynthesis and initial characterization of a PDE10A specific PET tracer [18 F]AMG 580 in non-human primates

Nuclear medicine and biology, 2015-08, Vol.42 (8), p.654-663

2015

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Trust and affect: how do they impact risk information seeking in a health context?

Journal of risk research, 2012-09, Vol.15 (8), p.897-911

2012

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Vaccination of Patients with Small-Cell Lung Cancer with Synthetic Fucosyl GM-1 Conjugated to Keyhole Limpet Hemocyanin

Clinical cancer research, 2004-09, Vol.10 (18), p.6094-6100

2004

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Discovery of AM-6494: A Potent and Orally Efficacious β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2

Journal of medicinal chemistry, 2020-03, Vol.63 (5), p.2263-2281

2020

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The role of affect in the decision to exercise: Does being happy lead to a more active lifestyle?

Psychology of sport and exercise, 2013-03, Vol.14 (2), p.275-282

2013

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Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe

Journal of medicinal chemistry, 2022-03, Vol.65 (6), p.4972-4990

2022

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AMG 193, a Clinical Stage MTA-Cooperative PRMT5 Inhibitor, Drives Antitumor Activity Preclinically and in Patients With MTAP-Deleted Cancers

Cancer discovery, 2024-09

2024

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Diastereoselective synthesis of fused cyclopropyl-3-amino-2,4-oxazine β-amyloid cleaving enzyme (BACE) inhibitors and their biological evaluation

Bioorganic & medicinal chemistry letters, 2018-04, Vol.28 (6), p.1111-1115

2018

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From the Laboratory to the Clinic: A Retrospective on Fully Synthetic Carbohydrate-Based Anticancer Vaccines

Angewandte Chemie (International ed.), 2000-03, Vol.39 (5), p.836-863

2000

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The development of a structurally distinct series of BACE1 inhibitors via the (Z)-fluoro-olefin amide bioisosteric replacement

Bioorganic & medicinal chemistry letters, 2020-07, Vol.30 (14), p.127240-127240, Article 127240

2020

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Unfolded Protein Response in Cancer: IRE1α Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability

ACS medicinal chemistry letters, 2015-01, Vol.6 (1), p.68-72

2015

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Discovery of a Covalent Inhibitor of KRAS G12C (AMG 510) for the Treatment of Solid Tumors

Journal of medicinal chemistry, 2020-01, Vol.63 (1), p.52-65

2020

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Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors

Journal of medicinal chemistry, 2020-01, Vol.63 (1), p.52-65

2020

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AMG 580: a novel small molecule phosphodiesterase 10A (PDE10A) positron emission tomography tracer

The Journal of pharmacology and experimental therapeutics, 2015-02, Vol.352 (2), p.327-337

2015

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Discovery of TRPM8 Antagonist (S)‑6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine

A Content Analysis of Coronavirus Tweets in the United States Just Prior to the Pandemic Declaration

College students' perceptions of COVID-19 conversations on social media

Design, Optimization, and Biological Evaluation of Novel Keto-Benzimidazoles as Potent and Selective Inhibitors of Phosphodiesterase 10A (PDE10A)

Discovery of Clinical Candidate 1‑(4-(3-(4-(1H‑Benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), A Potent, Selective, and Efficacious Inhibitor of Phosphodiesterase 10A (PDE10A)

Identification of Antibody and Small Molecule Antagonists of Ferroportin-Hepcidin Interaction

Initial characterization of a PDE10A selective positron emission tomography tracer [11 C]AMG 7980 in non-human primates

Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux

Discovery of Potent, Orally Bioavailable Phthalazinone Bradykinin B1 Receptor Antagonists

Rapid Identification of a Novel Small Molecule Phosphodiesterase 10A (PDE10A) Tracer

Radiosynthesis and initial characterization of a PDE10A specific PET tracer [18 F]AMG 580 in non-human primates

Trust and affect: how do they impact risk information seeking in a health context?

Vaccination of Patients with Small-Cell Lung Cancer with Synthetic Fucosyl GM-1 Conjugated to Keyhole Limpet Hemocyanin

Discovery of AM-6494: A Potent and Orally Efficacious β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2

The role of affect in the decision to exercise: Does being happy lead to a more active lifestyle?

Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe

AMG 193, a Clinical Stage MTA-Cooperative PRMT5 Inhibitor, Drives Antitumor Activity Preclinically and in Patients With MTAP-Deleted Cancers

Diastereoselective synthesis of fused cyclopropyl-3-amino-2,4-oxazine β-amyloid cleaving enzyme (BACE) inhibitors and their biological evaluation

From the Laboratory to the Clinic: A Retrospective on Fully Synthetic Carbohydrate-Based Anticancer Vaccines

The development of a structurally distinct series of BACE1 inhibitors via the (Z)-fluoro-olefin amide bioisosteric replacement

Unfolded Protein Response in Cancer: IRE1α Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability

Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers

Discovery of a Covalent Inhibitor of KRAS G12C (AMG 510) for the Treatment of Solid Tumors

Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors

AMG 580: a novel small molecule phosphodiesterase 10A (PDE10A) positron emission tomography tracer

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