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1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors

Bioorganic & medicinal chemistry letters, 2006-03, Vol.16 (6), p.1574-1578

2006

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1,2,4-Triazole d-ribose derivatives: Design, synthesis and antitumoral evaluation

European journal of medicinal chemistry, 2012, Vol.47 (1), p.104-110

2012

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1,2,4-Triazolo[3,4- a]pyridine as a novel, constrained template for fibrinogen receptor (GPIIb/IIIa) antagonists

Bioorganic & medicinal chemistry letters, 2001-10, Vol.11 (19), p.2619-2622

2001

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1,2,5,6-tetrahydropyridine oxime ethers incorporating electron withdrawing groups are potent and selective muscarinic agonists

Bioorganic & medicinal chemistry letters, 1994-02, Vol.4 (4), p.557-562

1994

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1-(2,5-Dimethoxy-4-(trifluoromethyl)phenyl)-2-aminopropane: A Potent Serotonin 5-HT2A/2C Agonist

Journal of medicinal chemistry, 1994-12, Vol.37 (25), p.4346-4351

1994

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1,2-Dibenzamidobenzene Inhibitors of Human Factor Xa

Journal of medicinal chemistry, 2000-03, Vol.43 (5), p.859-872

2000

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1-(2-Ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors

Bioorganic & medicinal chemistry letters, 2010-05, Vol.20 (10), p.3120-3124

2010

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1-[2-[(Heteroarylmethoxy)aryl]carbamoyl]indolines are selective and orally active 5-HT2C receptor inverse agonists

Bioorganic & medicinal chemistry letters, 2000-08, Vol.10 (16), p.1867-1870

2000

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1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines : Novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/anxiolytic agents

Bioorganic & medicinal chemistry letters, 2000-08, Vol.10 (16), p.1863-1866

2000

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1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor xa inhibitors. Part 2: A survey of P4 motifs

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (5), p.1221-1227

2004

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1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor xa inhibitors. Part 3: Design, synthesis and sar of orally bioavailable benzamidine-P4 inhibitors

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (5), p.1229-1234

2004

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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent Anti-HIV activity

Bioorganic & medicinal chemistry letters, 2001-10, Vol.11 (20), p.2741-2745

2001

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1,3-Diaryl-4,5,6,7-tetrahydro-2H-isoindole Derivatives: A New Series of Potent and Selective COX-2 Inhibitors in Which a Sulfonyl Group Is Not a Structural Requisite

Journal of medicinal chemistry, 2000-11, Vol.43 (24), p.4582-4593

2000

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1-[[(3-Hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: A Potent, Selective, and Orally Bioavailable Dipeptidyl Peptidase IV Inhibitor with Antihyperglycemic Properties

Journal of medicinal chemistry, 2003-06, Vol.46 (13), p.2774-2789

2003

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1,4-Benzodiazepin-2-one derived neurokinin-1 receptor antagonists

Bioorganic & medicinal chemistry letters, 1997-08, Vol.7 (15), p.2037-2042

1997

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1,4-Benzodiazepine-2,5-diones as small molecule antagonists of the HDM2–p53 interaction: discovery and SAR

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (3), p.765-770

2005

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1,4-Bis-(2,3-epoxypropylamino)-9,10-anthracenedione and related compounds as potent antifungal and antimicrobial agents

Bioorganic & medicinal chemistry letters, 1997-12, Vol.7 (24), p.3153-3158

1997

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1,4-substituted indoles: a potent and selective class of angiotensin II receptor antagonists

Bioorganic & medicinal chemistry letters, 1994-01, Vol.4 (1), p.145-150

1994

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1,5-Substituted nipecotic amides: Selective PDE8 inhibitors displaying diastereomer-dependent microsomal stability

Bioorganic & medicinal chemistry letters, 2011-05, Vol.21 (10), p.3095-3098

2011

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1,7-Annulated indolocarbazoles as cyclin-dependent kinase inhibitors

Bioorganic & medicinal chemistry letters, 2004-06, Vol.14 (12), p.3217-3220

2004

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1-Alkylcarbonyloxymethyl Prodrugs of 5-Fluorouracil (5-FU): Synthesis, Physicochemical Properties, and Topical Delivery of 5-FU

Journal of pharmaceutical sciences, 1998-01, Vol.87 (1), p.15-20

1998

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1-Aminocyclobutane-1-carboxylate (ACBC): a specific antagonist of the N-methyl-D-aspartate receptor coupled glycine receptor

European journal of pharmacology, 1989-02, Vol.161 (2), p.281-282

1989

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1-Aryl-3,4-dihydroisoquinoline inhibitors of JNK3

Bioorganic & medicinal chemistry letters, 2009-04, Vol.19 (8), p.2230-2234

2009

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1-Benzyloxy-4,5-dihydro- 1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists

Bioorganic & medicinal chemistry letters, 2003-10, Vol.13 (19), p.3155-3159

2003

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IL-1 dependent model of inflammation mediated by neutrophils

Journal of pharmacological methods, 1989-09, Vol.22 (2), p.133-140

1989

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1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors

1,2,4-Triazole d-ribose derivatives: Design, synthesis and antitumoral evaluation

1,2,4-Triazolo[3,4- a]pyridine as a novel, constrained template for fibrinogen receptor (GPIIb/IIIa) antagonists

1,2,5,6-tetrahydropyridine oxime ethers incorporating electron withdrawing groups are potent and selective muscarinic agonists

1-(2,5-Dimethoxy-4-(trifluoromethyl)phenyl)-2-aminopropane: A Potent Serotonin 5-HT2A/2C Agonist

1,2-Dibenzamidobenzene Inhibitors of Human Factor Xa

1-(2-Ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors

1-[2-[(Heteroarylmethoxy)aryl]carbamoyl]indolines are selective and orally active 5-HT2C receptor inverse agonists

1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines : Novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/anxiolytic agents

1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor xa inhibitors. Part 2: A survey of P4 motifs

1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor xa inhibitors. Part 3: Design, synthesis and sar of orally bioavailable benzamidine-P4 inhibitors

1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent Anti-HIV activity

1,3-Diaryl-4,5,6,7-tetrahydro-2H-isoindole Derivatives: A New Series of Potent and Selective COX-2 Inhibitors in Which a Sulfonyl Group Is Not a Structural Requisite

1-[[(3-Hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: A Potent, Selective, and Orally Bioavailable Dipeptidyl Peptidase IV Inhibitor with Antihyperglycemic Properties

1,4-Benzodiazepin-2-one derived neurokinin-1 receptor antagonists

1,4-Benzodiazepine-2,5-diones as small molecule antagonists of the HDM2–p53 interaction: discovery and SAR

1,4-Bis-(2,3-epoxypropylamino)-9,10-anthracenedione and related compounds as potent antifungal and antimicrobial agents

1,4-substituted indoles: a potent and selective class of angiotensin II receptor antagonists

1,5-Substituted nipecotic amides: Selective PDE8 inhibitors displaying diastereomer-dependent microsomal stability

1,7-Annulated indolocarbazoles as cyclin-dependent kinase inhibitors

1-Alkylcarbonyloxymethyl Prodrugs of 5-Fluorouracil (5-FU): Synthesis, Physicochemical Properties, and Topical Delivery of 5-FU

1-Aminocyclobutane-1-carboxylate (ACBC): a specific antagonist of the N-methyl-D-aspartate receptor coupled glycine receptor

1-Aryl-3,4-dihydroisoquinoline inhibitors of JNK3

1-Benzyloxy-4,5-dihydro- 1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists

IL-1 dependent model of inflammation mediated by neutrophils

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