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Comparison of azabicyclic esters and oxadiazoles as ligands for the muscarinic receptor

Journal of medicinal chemistry, 1991-09, Vol.34 (9), p.2726-2735

1991

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The discovery and optimisation of benzazepine sulfonamide and sulfones as potent agonists of the motilin receptor

Bioorganic & medicinal chemistry letters, 2009-11, Vol.19 (22), p.6452-6458

2009

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Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives

Journal of medicinal chemistry, 1992-04, Vol.35 (7), p.1280-1290

1992

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Design of [R-(Z)]-(+)-α-(Methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitrile (SB 202026), a Functionally Selective Azabicyclic Muscarinic M1 Agonist Incorporating the N-Methoxy Imidoyl Nitrile Group as a Novel Ester Bioisostere

Journal of medicinal chemistry, 1997-12, Vol.40 (26), p.4265-4280

1997

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Substituent variation in azabicyclic triazole- and tetrazole-based muscarinic receptor ligands

Journal of medicinal chemistry, 1992-06, Vol.35 (13), p.2392-2406

1992

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Synthesis of α-silylalkylbenzoxazoles and oxazoles from stable silylketenes

Tetrahedron, 2009-07, Vol.65 (28), p.5503-5512

2009

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A stereoselective synthesis of 3-substituted hexahydroindeno[2,1-b]pyrroles via an intramolecular azomethine ylide cycloaddition

Tetrahedron, 1998-12, Vol.54 (49), p.14905-14912

1998

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A Stereoselective Route to trans-1-Arylthio-2-aminoindanes

Synlett, 1996-05, Vol.1996 (5), p.477-478

Orlek, Barry S.

1996

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Stereoselective synthesis of protected amines and diamines from alkenes using N,N-Dichloro-t-butylcarbamate

Tetrahedron letters, 1991-08, Vol.32 (32), p.4045-4048

1991

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Characterisation of SB-221420-A - a neuronal Ca(2+) and Na(+) channel antagonist in experimental models of stroke

European journal of pharmacology, 2000-08, Vol.401 (3), p.419-428

2000

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Characterisation of SB-221420-A : a neuronal Ca2+ and Na+ channel antagonist in experimental models of stroke

European journal of pharmacology, 2000-08, Vol.401 (3), p.419-428

2000

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Evaluation of a series of anticonvulsant 1,2,3,4-tetrahydroisoquinolinyl-benzamides

Bioorganic & medicinal chemistry, 2000-08, Vol.8 (8), p.2085-2094

2000

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A molecular mechanism for toxin block in N-type calcium channels

Protein engineering, 1998-02, Vol.11 (2), p.95-99

1998

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Use of steric buttresses to enhance intramolecular cycloadditions

Journal of the Chemical Society. Chemical communications, 1993 (18), p.1412-1413

1993

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Steric acceleration of intramolecular azide cycloadditions

Journal of the Chemical Society. Chemical communications, 1993 (7), p.607-608

1993

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Identification of a series of 1,2,3,4-tetrahydroisoquinolinyl- benzamides with potential anticonvulsant activity

Bioorganic & medicinal chemistry letters, 1998-10, Vol.8 (20), p.2903-2906

1998

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On the chemistry of beta-lactamase inhibition by 6 beta-bromopenicillanic acid

Perkin transactions. 1, 1980, Vol.10, p.2322

1980

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Steric acceleration of intramolecular cycloaddition reactions

Tetrahedron, 1993-09, Vol.49 (36), p.8179-8194

1993

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A Short High Yielding Route to Methyl 2-(Quinuclidin-2-yl)acetate

Synlett, 1993-10, Vol.1993 (10), p.758-758

Orlek, Barry S.

1993

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Characterisation of SB-221420-A — a neuronal Ca 2+ and Na + channel antagonist in experimental models of stroke

European journal of pharmacology, 2000, Vol.401 (3), p.419-428

2000

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ChemInform Abstract: Synthesis of α-Silylalkylbenzoxazoles and Oxazoles from Stable Silylketenes

ChemInform, 2009-11, Vol.40 (44), p.no-no

2009

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On the chemical binding of 6β-bromopenicillanic acid to β-lactamase I

Journal of the Chemical Society. Chemical communications, 1979 (21), p.962-963

1979

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Diastereoselective routes to endo and exo ethyl 1-azabicyclo[2.2.1] hept-3-yl carboxylates

Tetrahedron letters, 1991-02, Vol.32 (9), p.1241-1244

1991

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Design and synthesis of novel muscarinic agonists containing the 1,2,4-triazine ring as an ester bioisostere

Bioorganic & medicinal chemistry letters, 1994-06, Vol.4 (12), p.1411-1414

1994

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Diastereoselective routes to [formula omitted] and [formula omitted] ethyl 1-azabicyclo[2.2.1] hept-3-YL carboxylates

Tetrahedron letters, 1991-02, Vol.32 (9), p.1241-1244

1991

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Comparison of azabicyclic esters and oxadiazoles as ligands for the muscarinic receptor

The discovery and optimisation of benzazepine sulfonamide and sulfones as potent agonists of the motilin receptor

Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives

Design of [R-(Z)]-(+)-α-(Methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitrile (SB 202026), a Functionally Selective Azabicyclic Muscarinic M1 Agonist Incorporating the N-Methoxy Imidoyl Nitrile Group as a Novel Ester Bioisostere

Substituent variation in azabicyclic triazole- and tetrazole-based muscarinic receptor ligands

Synthesis of α-silylalkylbenzoxazoles and oxazoles from stable silylketenes

A stereoselective synthesis of 3-substituted hexahydroindeno[2,1-b]pyrroles via an intramolecular azomethine ylide cycloaddition

A Stereoselective Route to trans-1-Arylthio-2-aminoindanes

Stereoselective synthesis of protected amines and diamines from alkenes using N,N-Dichloro-t-butylcarbamate

Characterisation of SB-221420-A - a neuronal Ca(2+) and Na(+) channel antagonist in experimental models of stroke

Characterisation of SB-221420-A : a neuronal Ca2+ and Na+ channel antagonist in experimental models of stroke

Evaluation of a series of anticonvulsant 1,2,3,4-tetrahydroisoquinolinyl-benzamides

A molecular mechanism for toxin block in N-type calcium channels

Use of steric buttresses to enhance intramolecular cycloadditions

Steric acceleration of intramolecular azide cycloadditions

Identification of a series of 1,2,3,4-tetrahydroisoquinolinyl- benzamides with potential anticonvulsant activity

On the chemistry of beta-lactamase inhibition by 6 beta-bromopenicillanic acid

Steric acceleration of intramolecular cycloaddition reactions

A Short High Yielding Route to Methyl 2-(Quinuclidin-2-yl)acetate

Characterisation of SB-221420-A — a neuronal Ca 2+ and Na + channel antagonist in experimental models of stroke

ChemInform Abstract: Synthesis of α-Silylalkylbenzoxazoles and Oxazoles from Stable Silylketenes

On the chemical binding of 6β-bromopenicillanic acid to β-lactamase I

Diastereoselective routes to endo and exo ethyl 1-azabicyclo[2.2.1] hept-3-yl carboxylates

Design and synthesis of novel muscarinic agonists containing the 1,2,4-triazine ring as an ester bioisostere

Diastereoselective routes to [formula omitted] and [formula omitted] ethyl 1-azabicyclo[2.2.1] hept-3-YL carboxylates

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