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NSD2 contributes to oncogenic RAS-driven transcription in lung cancer cells through long-range epigenetic activation

Scientific reports, 2016-09, Vol.6 (1), p.32952, Article 32952

2016

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Characterization of LY2228820 dimesylate, a potent and selective inhibitor of p38 MAPK with antitumor activity

Molecular cancer therapeutics, 2014-02, Vol.13 (2), p.364-374

2014

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Synthesis, Structure−Activity Relationship, and Biological Studies of Indolocarbazoles as Potent Cyclin D1-CDK4 Inhibitors

Journal of medicinal chemistry, 2003-05, Vol.46 (11), p.2027-2030

2003

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Discovery of N‑(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)‑3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model

Journal of medicinal chemistry, 2017-12, Vol.60 (23), p.9599-9616

2017

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Novel, potent and selective cyclin D1/CDK4 inhibitors: indolo[6,7- a]pyrrolo[3,4- c]carbazoles

Bioorganic & medicinal chemistry letters, 2003-07, Vol.13 (14), p.2261-2267

2003

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Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models

Scientific reports, 2018-10, Vol.8 (1), p.15458-12, Article 15458

2018

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Structure-based design of a new class of highly selective aminoimidazo[1,2- a]pyridine-based inhibitors of cyclin dependent kinases

Bioorganic & medicinal chemistry letters, 2005-04, Vol.15 (7), p.1943-1947

2005

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Kinetic Characterization of Novel Pyrazole TGF-β Receptor I Kinase Inhibitors and Their Blockade of the Epithelial−Mesenchymal Transition

Biochemistry (Easton), 2005-02, Vol.44 (7), p.2293-2304

2005

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Glioma-propagating cells as an in vitro screening platform: PLK1 as a case study

Journal of biomolecular screening, 2012-10, Vol.17 (9), p.1136-1150

2012

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X-ray Structure of Ornithine Decarboxylase from Trypanosoma brucei: The Native Structure and the Structure in Complex with α-Difluoromethylornithine

Biochemistry (Easton), 1999-11, Vol.38 (46), p.15174-15184

1999

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Altering the Reaction Specificity of Eukaryotic Ornithine Decarboxylase

Biochemistry (Easton), 2000-09, Vol.39 (37), p.11247-11257

2000

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Ornithine Decarboxylase Promotes Catalysis by Binding the Carboxylate in a Buried Pocket Containing Phenylalanine 397

Biochemistry (Easton), 2003-03, Vol.42 (10), p.2933-2940

2003

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Aminoimidazo[1,2- a]pyridines as a new structural class of cyclin-dependent kinase inhibitors. Part 1: Design, synthesis, and biological evaluation

Bioorganic & medicinal chemistry letters, 2004-12, Vol.14 (24), p.6095-6099

2004

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Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (21), p.3841-3846

2003

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Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (21), p.3835-3839

2003

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Synthesis of quinolinyl/isoquinolinyl[ a]pyrrolo [3,4- c] carbazoles as cyclin D1/CDK4 inhibitors

Bioorganic & medicinal chemistry letters, 2003-04, Vol.13 (7), p.1231-1235

2003

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Kinetic and Thermodynamic Analysis of a Physiologic Intermolecular Electron-Transfer Reaction between Methylamine Dehydrogenase and Amicyanin

Biochemistry (Easton), 1994-05, Vol.33 (19), p.5696-5701

1994

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Lysine-69 Plays a Key Role in Catalysis by Ornithine Decarboxylase through Acceleration of the Schiff Base Formation, Decarboxylation, and Product Release Steps

Biochemistry (Easton), 1999-09, Vol.38 (36), p.11814-11826

1999

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1,7-Annulated indolocarbazoles as cyclin-dependent kinase inhibitors

Bioorganic & medicinal chemistry letters, 2004-06, Vol.14 (12), p.3217-3220

2004

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Preparation of novel aza-1,7-annulated indoles and their conversion to potent indolocarbazole kinase inhibitors

Bioorganic & medicinal chemistry letters, 2004-08, Vol.14 (15), p.3925-3928

2004

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Characterization of the Reaction Mechanism for Trypanosoma brucei Ornithine Decarboxylase by Multiwavelength Stopped-Flow Spectroscopy

Biochemistry (Easton), 1997-12, Vol.36 (49), p.15147-15155

1997

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Abstract P142: Preclinical characterization of LOX-22783, a highly potent, mutant-selective and brain-penetrant allosteric PI3Kα H1047R inhibitor

Molecular cancer therapeutics, 2021-12, Vol.20 (12_Supplement), p.P142-P142

2021

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Free energy dependence of the electron transfer reaction between methylamine dehydrogenase and amicyanin

Journal of the American Chemical Society, 1994-11, Vol.116 (24), p.11201-11202

1994

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Role of Arg-277 in the Binding of Pyridoxal 5‘-Phosphate to Trypanosoma brucei Ornithine Decarboxylase

Biochemistry (Easton), 1997-04, Vol.36 (15), p.4558-4567

1997

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NSD2 contributes to oncogenic RAS-driven transcription in lung cancer cells through long-range epigenetic activation

Characterization of LY2228820 dimesylate, a potent and selective inhibitor of p38 MAPK with antitumor activity

Synthesis, Structure−Activity Relationship, and Biological Studies of Indolocarbazoles as Potent Cyclin D1-CDK4 Inhibitors

Novel, potent and selective cyclin D1/CDK4 inhibitors: indolo[6,7- a]pyrrolo[3,4- c]carbazoles

Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models

Structure-based design of a new class of highly selective aminoimidazo[1,2- a]pyridine-based inhibitors of cyclin dependent kinases

Kinetic Characterization of Novel Pyrazole TGF-β Receptor I Kinase Inhibitors and Their Blockade of the Epithelial−Mesenchymal Transition

Glioma-propagating cells as an in vitro screening platform: PLK1 as a case study

X-ray Structure of Ornithine Decarboxylase from Trypanosoma brucei: The Native Structure and the Structure in Complex with α-Difluoromethylornithine

Altering the Reaction Specificity of Eukaryotic Ornithine Decarboxylase

Ornithine Decarboxylase Promotes Catalysis by Binding the Carboxylate in a Buried Pocket Containing Phenylalanine 397

Aminoimidazo[1,2- a]pyridines as a new structural class of cyclin-dependent kinase inhibitors. Part 1: Design, synthesis, and biological evaluation

Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides

Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors

Synthesis of quinolinyl/isoquinolinyl[ a]pyrrolo [3,4- c] carbazoles as cyclin D1/CDK4 inhibitors

Kinetic and Thermodynamic Analysis of a Physiologic Intermolecular Electron-Transfer Reaction between Methylamine Dehydrogenase and Amicyanin

The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines

Lysine-69 Plays a Key Role in Catalysis by Ornithine Decarboxylase through Acceleration of the Schiff Base Formation, Decarboxylation, and Product Release Steps

1,7-Annulated indolocarbazoles as cyclin-dependent kinase inhibitors

Preparation of novel aza-1,7-annulated indoles and their conversion to potent indolocarbazole kinase inhibitors

Characterization of the Reaction Mechanism for Trypanosoma brucei Ornithine Decarboxylase by Multiwavelength Stopped-Flow Spectroscopy

Abstract P142: Preclinical characterization of LOX-22783, a highly potent, mutant-selective and brain-penetrant allosteric PI3Kα H1047R inhibitor

Free energy dependence of the electron transfer reaction between methylamine dehydrogenase and amicyanin

Role of Arg-277 in the Binding of Pyridoxal 5‘-Phosphate to Trypanosoma brucei Ornithine Decarboxylase

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