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Human Antibodies that Neutralize HIV-1: Identification, Structures, and B Cell Ontogenies

Immunity (Cambridge, Mass.), 2012-09, Vol.37 (3), p.412-425

2012

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Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization

Cell, 2013-03, Vol.153 (1), p.126-138

2013

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Structure of Respiratory Syncytial Virus Fusion Glycoprotein in the Postfusion Conformation Reveals Preservation of Neutralizing Epitopes

Journal of Virology, 2011-08, Vol.85 (15), p.7788-7796

2011

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Cooperation of B Cell Lineages in Induction of HIV-1-Broadly Neutralizing Antibodies

Cell, 2014-07, Vol.158 (3), p.481-491

2014

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Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

Nature (London), 2012-11, Vol.491 (7424), p.406-412

2012

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Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

Science (American Association for the Advancement of Science), 2010-08, Vol.329 (5993), p.811-817

2010

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Microsecond Dynamics and Network Analysis of the HIV-1 SOSIP Env Trimer Reveal Collective Behavior and Conserved Microdomains of the Glycan Shield

Structure (London), 2017-10, Vol.25 (10), p.1631-1639.e2

2017

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Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses

Cell, 2016-07, Vol.166 (3), p.609-623

2016

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Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

Science (American Association for the Advancement of Science), 2011-09, Vol.333 (6049), p.1593-1602

2011

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Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1

Journal of Virology, 2010-08, Vol.84 (16), p.8098-8110

2010

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Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8

PloS one, 2016-06, Vol.11 (6), p.e0157409

2016

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Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops

Proceedings of the National Academy of Sciences - PNAS, 2012-04, Vol.109 (15), p.5663-5668

2012

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Crystal structure of a fully glycosylated HIV-1 gp120 core reveals a stabilizing role for the glycan at Asn262

Proteins, structure, function, and bioinformatics, 2015-03, Vol.83 (3), p.590-596

2015

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Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold

Science (American Association for the Advancement of Science), 2011-10, Vol.334 (6054), p.373-376

2011

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Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility

Proceedings of the National Academy of Sciences - PNAS, 2010-01, Vol.107 (3), p.1166-1171

2010

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Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus Infection

Journal of virology, 2015-08, Vol.89 (16), p.8334-8345

2015

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Topological Layers in the HIV-1 gp120 Inner Domain Regulate gp41 Interaction and CD4-Triggered Conformational Transitions

Molecular cell, 2010-03, Vol.37 (5), p.656-667

2010

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Structural definition of a conserved neutralization epitope on HIV-1 gp120

Nature, 2007-02, Vol.445 (7129), p.732-737

2007

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Completeness of HIV-1 Envelope Glycan Shield at Transmission Determines Neutralization Breadth

Cell reports (Cambridge), 2018-10, Vol.25 (4), p.893-908.e7

2018

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Structure of a V3-Containing HIV-1 gp120 Core

Science (American Association for the Advancement of Science), 2005-11, Vol.310 (5750), p.1025-1028

2005

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Crystal Structures of GII.10 and GII.12 Norovirus Protruding Domains in Complex with Histo-Blood Group Antigens Reveal Details for a Potential Site of Vulnerability

Journal of Virology, 2011-07, Vol.85 (13), p.6687-6701

2011

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Structure and Mechanistic Analysis of the Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5 in Complex with Its gp41 Epitope

Journal of Virology, 2004-10, Vol.78 (19), p.10724-10737

2004

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Human Antibodies that Neutralize HIV-1: Identification, Structures, and B Cell Ontogenies

Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization

Structure of Respiratory Syncytial Virus Fusion Glycoprotein in the Postfusion Conformation Reveals Preservation of Neutralizing Epitopes

Cooperation of B Cell Lineages in Induction of HIV-1-Broadly Neutralizing Antibodies

Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G

Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

Microsecond Dynamics and Network Analysis of the HIV-1 SOSIP Env Trimer Reveal Collective Behavior and Conserved Microdomains of the Glycan Shield

Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses

Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1

Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8

Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies

Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops

Crystal structure of a fully glycosylated HIV-1 gp120 core reveals a stabilizing role for the glycan at Asn262

Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold

Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility

Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus Infection

Topological Layers in the HIV-1 gp120 Inner Domain Regulate gp41 Interaction and CD4-Triggered Conformational Transitions

Structural definition of a conserved neutralization epitope on HIV-1 gp120

Completeness of HIV-1 Envelope Glycan Shield at Transmission Determines Neutralization Breadth

Immunoglobulin Gene Insertions and Deletions in the Affinity Maturation of HIV-1 Broadly Reactive Neutralizing Antibodies

Structure of a V3-Containing HIV-1 gp120 Core

Crystal Structures of GII.10 and GII.12 Norovirus Protruding Domains in Complex with Histo-Blood Group Antigens Reveal Details for a Potential Site of Vulnerability

Structure and Mechanistic Analysis of the Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5 in Complex with Its gp41 Epitope

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