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Medicinal Chemistry Perspective of Fused Isoxazole Derivatives

Current topics in medicinal chemistry, 2016-10, Vol.16 (26), p.2863

2016

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Isoxazole ring as a useful scaffold in a search for new therapeutic agents

European journal of medicinal chemistry, 2017-09, Vol.137, p.292-309

2017

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An Isoxazole Strategy for Molybdenum-Mediated Synthesis of 5-Mono- and 4,5-Disubstituted 1 H -Pyrrole-2,3-diones

Journal of organic chemistry, 2022-05, Vol.87 (9), p.6459-6470

2022

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Phase I Trial of First-in-Class ATR Inhibitor M6620 (VX-970) as Monotherapy or in Combination With Carboplatin in Patients With Advanced Solid Tumors

Journal of clinical oncology, 2020-09, Vol.38 (27), p.3195-3204

2020

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Antimicrobial, Antioxidant, and Anticancer Activities of Some Novel Isoxazole Ring Containing Chalcone and Dihydropyrazole Derivatives

Molecules (Basel, Switzerland), 2020-02, Vol.25 (5), p.1047

2020

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Direct ring fluorination of 3-substituted 5-(1,3-dioxane) acetal isoxazoles: application to the formal synthesis of a bioactive fluorinated isoxazole

Comptes rendus. Chimie, 2024-07, Vol.27 (S2), p.33-38

2024

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Isoxazole Derivatives as Regulators of Immune Functions

Molecules (Basel, Switzerland), 2018-10, Vol.23 (10), p.2724

2018

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Isoxazolidine: A Privileged Scaffold for Organic and Medicinal Chemistry

Chemical reviews, 2016-12, Vol.116 (24), p.15235-15283

2016

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Discovery and mode of action of afoxolaner, a new isoxazoline parasiticide for dogs

Veterinary parasitology, 2014-04, Vol.201 (3-4), p.179-189

2014

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Structure-guided modification of isoxazole-type FXR agonists: Identification of a potent and orally bioavailable FXR modulator

European journal of medicinal chemistry, 2021-01, Vol.209, p.112910-112910, Article 112910

2021

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Isoxazoline containing natural products as anticancer agents: A review

European journal of medicinal chemistry, 2014-04, Vol.77, p.121-133

2014

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Phase 1 study of the ATR inhibitor berzosertib (formerly M6620, VX-970) combined with gemcitabine ± cisplatin in patients with advanced solid tumours

British journal of cancer, 2021-08, Vol.125 (4), p.510-519

2021

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Development and comparison of intramuscularly long-acting paliperidone palmitate nanosuspensions with different particle size

International journal of pharmaceutics, 2014-09, Vol.472 (1-2), p.380-385

2014

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Exploration of isoxazole analogs: Synthesis, COX inhibition, anticancer screening, 3D multicellular tumor spheroids, and molecular modeling

European journal of medicinal chemistry, 2024-05, Vol.271, p.116397-116397, Article 116397

2024

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Efficacy and Safety of the 3-Month Formulation of Paliperidone Palmitate vs Placebo for Relapse Prevention of Schizophrenia: A Randomized Clinical Trial

JAMA psychiatry (Chicago, Ill.), 2015-08, Vol.72 (8), p.830

2015

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Design, synthesis, and biological evaluation of 5-(1H-indol-5-yl)isoxazole-3-carboxylic acids as novel xanthine oxidase inhibitors

European journal of medicinal chemistry, 2024-05, Vol.271, p.116443-116443, Article 116443

2024

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Synthesis and antioxidant activity of oxazolyl/thiazolylsulfonylmethyl pyrazoles and isoxazoles

European journal of medicinal chemistry, 2011-10, Vol.46 (10), p.5034-5038

2011

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Synthesis of novel triazole/isoxazole functionalized 7-(trifluoromethyl)pyrido[2,3-d]pyrimidine derivatives as promising anticancer and antibacterial agents

Bioorganic & medicinal chemistry letters, 2016-06, Vol.26 (12), p.2927-2930

2016

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Crystal structure of the human σ1 receptor

Nature (London), 2016-04, Vol.532 (7600), p.527-530

2016

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Phase 1 study of the ATR inhibitor berzosertib in combination with cisplatin in patients with advanced solid tumours

British journal of cancer, 2021-08, Vol.125 (4), p.520-527

2021

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Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6)

European journal of medicinal chemistry, 2017-09, Vol.138 (C), p.661-668

2017

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Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents

European journal of medicinal chemistry, 2011-02, Vol.46 (2), p.691-703

2011

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Real-world outcomes of paliperidone palmitate compared to daily oral antipsychotic therapy in schizophrenia: a randomized, open-label, review board-blinded 15-month study

The journal of clinical psychiatry, 2015-05, Vol.76 (5), p.554

2015

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Activation and allosteric modulation of a muscarinic acetylcholine receptor

Nature (London), 2013-12, Vol.504 (7478), p.101-106

2013

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Medicinal Chemistry Perspective of Fused Isoxazole Derivatives

Isoxazole ring as a useful scaffold in a search for new therapeutic agents

An Isoxazole Strategy for Molybdenum-Mediated Synthesis of 5-Mono- and 4,5-Disubstituted 1 H -Pyrrole-2,3-diones

Phase I Trial of First-in-Class ATR Inhibitor M6620 (VX-970) as Monotherapy or in Combination With Carboplatin in Patients With Advanced Solid Tumors

Antimicrobial, Antioxidant, and Anticancer Activities of Some Novel Isoxazole Ring Containing Chalcone and Dihydropyrazole Derivatives

Direct ring fluorination of 3-substituted 5-(1,3-dioxane) acetal isoxazoles: application to the formal synthesis of a bioactive fluorinated isoxazole

Isoxazole Derivatives as Regulators of Immune Functions

Isoxazolidine: A Privileged Scaffold for Organic and Medicinal Chemistry

Discovery and mode of action of afoxolaner, a new isoxazoline parasiticide for dogs

DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors

Structure-guided modification of isoxazole-type FXR agonists: Identification of a potent and orally bioavailable FXR modulator

Isoxazoline containing natural products as anticancer agents: A review

Phase 1 study of the ATR inhibitor berzosertib (formerly M6620, VX-970) combined with gemcitabine ± cisplatin in patients with advanced solid tumours

Development and comparison of intramuscularly long-acting paliperidone palmitate nanosuspensions with different particle size

Exploration of isoxazole analogs: Synthesis, COX inhibition, anticancer screening, 3D multicellular tumor spheroids, and molecular modeling

Efficacy and Safety of the 3-Month Formulation of Paliperidone Palmitate vs Placebo for Relapse Prevention of Schizophrenia: A Randomized Clinical Trial

Design, synthesis, and biological evaluation of 5-(1H-indol-5-yl)isoxazole-3-carboxylic acids as novel xanthine oxidase inhibitors

Synthesis and antioxidant activity of oxazolyl/thiazolylsulfonylmethyl pyrazoles and isoxazoles

Synthesis of novel triazole/isoxazole functionalized 7-(trifluoromethyl)pyrido[2,3-d]pyrimidine derivatives as promising anticancer and antibacterial agents

Crystal structure of the human σ1 receptor

Phase 1 study of the ATR inhibitor berzosertib in combination with cisplatin in patients with advanced solid tumours

Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6)

Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents

Real-world outcomes of paliperidone palmitate compared to daily oral antipsychotic therapy in schizophrenia: a randomized, open-label, review board-blinded 15-month study

Activation and allosteric modulation of a muscarinic acetylcholine receptor

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