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3D human liver spheroids for translational pharmacology and toxicology

Basic & clinical pharmacology & toxicology, 2022-01, Vol.130 (S1), p.5-15

2022

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Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long‐term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics

The FASEB journal, 2017-06, Vol.31 (6), p.2696-2708

2017

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How to Consider Rare Genetic Variants in Personalized Drug Therapy

Clinical pharmacology and therapeutics, 2018-05, Vol.103 (5), p.745-748

2018

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Human soluble ACE2 improves the effect of remdesivir in SARS‐CoV‐2 infection

EMBO molecular medicine, 2021-01, Vol.13 (1), p.e13426-n/a

2021

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Development of the PGx‐Passport: A Panel of Actionable Germline Genetic Variants for Pre‐Emptive Pharmacogenetic Testing

Clinical pharmacology and therapeutics, 2019-10, Vol.106 (4), p.866-873

2019

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Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation

Hepatology (Baltimore, Md.), 2016-11, Vol.64 (5), p.1743-1756

2016

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Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three‐Dimensional Spheroid Cultures of Primary Human Hepatocytes

Clinical pharmacology and therapeutics, 2020-10, Vol.108 (4), p.844-855

2020

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Cross‐Ancestry Genome‐Wide Association Study Defines the Extended CYP2D6 Locus as the Principal Genetic Determinant of Endoxifen Plasma Concentrations

Clinical pharmacology and therapeutics, 2023-03, Vol.113 (3), p.712-723

2023

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The Past, Present and Future of Intestinal In Vitro Cell Systems for Drug Absorption Studies

Journal of pharmaceutical sciences, 2021-01, Vol.110 (1), p.50-65

2021

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A 3D Cell Culture Model Identifies Wnt/β‐Catenin Mediated Inhibition of p53 as a Critical Step during Human Hepatocyte Regeneration

Advanced science, 2020-08, Vol.7 (15), p.2000248-n/a

2020

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Robust and Seamless Integration of Thiol‐Ene‐Epoxy Thermosets with Thermoplastics and Glass as Hybrid Microfluidic Devices Suitable for Drug Studies

Advanced materials interfaces, 2024-05, Vol.11 (14), p.n/a

2024

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Bioengineered Pancreas–Liver Crosstalk in a Microfluidic Coculture Chip Identifies Human Metabolic Response Signatures in Prediabetic Hyperglycemia

Advanced science, 2022-12, Vol.9 (34), p.e2203368-n/a

2022

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Computational Tools to Assess the Functional Consequences of Rare and Noncoding Pharmacogenetic Variability

Clinical pharmacology and therapeutics, 2021-09, Vol.110 (3), p.626-636

2021

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Two different isoforms of osteopontin modulate myelination and axonal integrity

FASEB bioAdvances, 2023-08, Vol.5 (8), p.336-353

2023

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Rewiring of catecholamine‐induced calcium signalling is an early event in non‐alcoholic fatty liver disease

The Journal of physiology, 2023-04, Vol.601 (8), p.1317-1318

2023

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Global Frequencies of Clinically Important HLA Alleles and Their Implications For the Cost‐Effectiveness of Preemptive Pharmacogenetic Testing

Clinical pharmacology and therapeutics, 2021-01, Vol.109 (1), p.160-174

2021

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Insulin‐dependent glucose consumption dynamics in 3D primary human liver cultures measured by a sensitive and specific glucose sensor with nanoliter input volume

The FASEB journal, 2021-03, Vol.35 (3), p.e21305-n/a

2021

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3D Primary Hepatocyte Culture Systems for Analyses of Liver Diseases, Drug Metabolism, and Toxicity: Emerging Culture Paradigms and Applications

Biotechnology journal, 2019-07, Vol.14 (7), p.e1800347-n/a

2019

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A paradigm shift in pharmacogenomics: From candidate polymorphisms to comprehensive sequencing

Basic & clinical pharmacology & toxicology, 2022-12, Vol.131 (6), p.452-464

2022

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Germline variant burden in multidrug resistance transporters is a therapy‐specific predictor of survival in breast cancer patients

International journal of cancer, 2020-05, Vol.146 (9), p.2475-2487

2020

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Translating pharmacogenomic sequencing data into drug response predictions—How to interpret variants of unknown significance

British journal of clinical pharmacology, 2023

2023

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PharmVar GeneFocus: CYP2B6

Clinical pharmacology and therapeutics, 2021-07, Vol.110 (1), p.82-97

2021

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Proteomic workflows for deep phenotypic profiling of 3D organotypic liver models

Biotechnology journal, 2024-03, Vol.19 (3), p.e2300684-n/a

2024

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The choice of ultra‐low attachment plates impacts primary human and primary canine hepatocyte spheroid formation, phenotypes, and function

Biotechnology journal, 2024-02, Vol.19 (2), p.e2300587-n/a

2024

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Wnt/β-catenin and NFκB signaling synergize to trigger growth factor-free regeneration of adult primary human hepatocytes

Hepatology (Baltimore, Md.), 2024-06, Vol.79 (6), p.1337-1351

2024

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3D human liver spheroids for translational pharmacology and toxicology

Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long‐term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics

How to Consider Rare Genetic Variants in Personalized Drug Therapy

Human soluble ACE2 improves the effect of remdesivir in SARS‐CoV‐2 infection

Development of the PGx‐Passport: A Panel of Actionable Germline Genetic Variants for Pre‐Emptive Pharmacogenetic Testing

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation

Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three‐Dimensional Spheroid Cultures of Primary Human Hepatocytes

Cross‐Ancestry Genome‐Wide Association Study Defines the Extended CYP2D6 Locus as the Principal Genetic Determinant of Endoxifen Plasma Concentrations

The Past, Present and Future of Intestinal In Vitro Cell Systems for Drug Absorption Studies

A 3D Cell Culture Model Identifies Wnt/β‐Catenin Mediated Inhibition of p53 as a Critical Step during Human Hepatocyte Regeneration

Robust and Seamless Integration of Thiol‐Ene‐Epoxy Thermosets with Thermoplastics and Glass as Hybrid Microfluidic Devices Suitable for Drug Studies

Bioengineered Pancreas–Liver Crosstalk in a Microfluidic Coculture Chip Identifies Human Metabolic Response Signatures in Prediabetic Hyperglycemia

Computational Tools to Assess the Functional Consequences of Rare and Noncoding Pharmacogenetic Variability

Two different isoforms of osteopontin modulate myelination and axonal integrity

Rewiring of catecholamine‐induced calcium signalling is an early event in non‐alcoholic fatty liver disease

Global Frequencies of Clinically Important HLA Alleles and Their Implications For the Cost‐Effectiveness of Preemptive Pharmacogenetic Testing

Insulin‐dependent glucose consumption dynamics in 3D primary human liver cultures measured by a sensitive and specific glucose sensor with nanoliter input volume

3D Primary Hepatocyte Culture Systems for Analyses of Liver Diseases, Drug Metabolism, and Toxicity: Emerging Culture Paradigms and Applications

A paradigm shift in pharmacogenomics: From candidate polymorphisms to comprehensive sequencing

Germline variant burden in multidrug resistance transporters is a therapy‐specific predictor of survival in breast cancer patients

Translating pharmacogenomic sequencing data into drug response predictions—How to interpret variants of unknown significance

PharmVar GeneFocus: CYP2B6

Proteomic workflows for deep phenotypic profiling of 3D organotypic liver models

The choice of ultra‐low attachment plates impacts primary human and primary canine hepatocyte spheroid formation, phenotypes, and function

Wnt/β-catenin and NFκB signaling synergize to trigger growth factor-free regeneration of adult primary human hepatocytes

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