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Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7

Cell, 2019-08, Vol.178 (5), p.1222-1230.e10

2019

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Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody

eLife, 2017-02, Vol.6

2017

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A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence

Nature communications, 2023-12, Vol.14 (1), p.8039-8039, Article 8039

2023

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Stepwise Evolution Improves Identification of Diverse Peptides Binding to a Protein Target

Scientific reports, 2017-09, Vol.7 (1), p.12116-10, Article 12116

2017

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Systematic Investigation of Halogen Bonding in Protein-Ligand Interactions

Angewandte Chemie (International ed.), 2011-01, Vol.50 (1), p.314-318

International ed. in English, 2011

Volltextzugriff (PDF)

Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β

Journal of Alzheimer's disease, 2012-01, Vol.28 (1), p.49

2012

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Variable heavy-variable light domain and Fab-arm CrossMabs with charged residue exchanges to enforce correct light chain assembly

Protein engineering, design and selection, 2018-07, Vol.31 (7-8), p.289-299

2018

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Structure of the acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1

Nature communications, 2012-07, Vol.3 (1), p.936-936, Article 936

2012

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Mapping the conformational space accessible to catechol-O-methyltransferase

Acta crystallographica. Section D, Biological crystallography., 2014-08, Vol.70 (8), p.2163-2174

2014

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Molecular Switch in the Glucocorticoid Receptor: Active and Passive Antagonist Conformations

Journal of molecular biology, 2010-01, Vol.395 (3), p.568-577

2010

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MoFvAb: Modeling the Fv region of antibodies

mAbs, 2015-09, Vol.7 (5), p.838-852

2015

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VH-VL orientation prediction for antibody humanization candidate selection: A case study

mAbs, 2016-01, Vol.8 (2), p.288-305

2016

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Structure of Gentlyase, the neutral metalloprotease of Paenibacillus polymyxa

Acta crystallographica. Section D, Biological crystallography., 2013-01, Vol.69 (1), p.24-31

2013

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Enhancing the Stability and Solubility of the Glucocorticoid Receptor Ligand-Binding Domain by High-Throughput Library Screening

Journal of molecular biology, 2010-11, Vol.403 (4), p.562-577

2010

Volltextzugriff (PDF)

Determination of Protein–Ligand Binding Constants of a Cooperatively Regulated Tetrameric Enzyme Using Electrospray Mass Spectrometry

ACS chemical biology, 2014-01, Vol.9 (1), p.218-226

2014

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Structure of the Human Fatty Acid Synthase KS–MAT Didomain as a Framework for Inhibitor Design

Journal of molecular biology, 2010-03, Vol.397 (2), p.508-519

2010

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BACE1 inhibitors: A head group scan on a series of amides

Bioorganic & medicinal chemistry letters, 2013-07, Vol.23 (14), p.4239-4243

2013

Volltextzugriff (PDF)

The structure of human α-2,6-sialyltransferase reveals the binding mode of complex glycans

Acta crystallographica. Section D, Biological crystallography., 2013-09, Vol.69 (9), p.1826-1838

2013

Volltextzugriff (PDF)

Halogen Bonding at the Active Sites of Human Cathepsin L and MEK1 Kinase: Efficient Interactions in Different Environments

ChemMedChem, 2011-11, Vol.6 (11), p.2048-2054

2011

Volltextzugriff (PDF)

Comparative Molecular Profiling of the PPARα/γ Activator Aleglitazar: PPAR Selectivity, Activity and Interaction with Cofactors

ChemMedChem, 2012-06, Vol.7 (6), p.1101-1111

2012

Volltextzugriff (PDF)

Structural basis for the cyclophilin A binding affinity and immunosuppressive potency of E-ISA247 (voclosporin)

Acta crystallographica. Section D, Biological crystallography., 2011-02, Vol.67 (2), p.119-123

2011

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Fragment-Based Screening Using Surface Plasmon Resonance Technology

Journal of biomolecular screening, 2009-04, Vol.14 (4), p.337-349

2009

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Identification of Potent and Selective Cathepsin S Inhibitors Containing Different Central Cyclic Scaffolds

Journal of medicinal chemistry, 2013-12, Vol.56 (23), p.9789-9801

2013

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Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7

Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody

A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence

Stepwise Evolution Improves Identification of Diverse Peptides Binding to a Protein Target

Targeting Tumor-Associated Macrophages with Anti-CSF-1R Antibody Reveals a Strategy for Cancer Therapy

Systematic Investigation of Halogen Bonding in Protein-Ligand Interactions

Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β

Variable heavy-variable light domain and Fab-arm CrossMabs with charged residue exchanges to enforce correct light chain assembly

Structure of the acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1

CD25-T reg -depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation and antitumor immunity

Mapping the conformational space accessible to catechol-O-methyltransferase

Molecular Switch in the Glucocorticoid Receptor: Active and Passive Antagonist Conformations

MoFvAb: Modeling the Fv region of antibodies

VH-VL orientation prediction for antibody humanization candidate selection: A case study

Structure of Gentlyase, the neutral metalloprotease of Paenibacillus polymyxa

Enhancing the Stability and Solubility of the Glucocorticoid Receptor Ligand-Binding Domain by High-Throughput Library Screening

Determination of Protein–Ligand Binding Constants of a Cooperatively Regulated Tetrameric Enzyme Using Electrospray Mass Spectrometry

Structure of the Human Fatty Acid Synthase KS–MAT Didomain as a Framework for Inhibitor Design

BACE1 inhibitors: A head group scan on a series of amides

The structure of human α-2,6-sialyltransferase reveals the binding mode of complex glycans

Halogen Bonding at the Active Sites of Human Cathepsin L and MEK1 Kinase: Efficient Interactions in Different Environments

Comparative Molecular Profiling of the PPARα/γ Activator Aleglitazar: PPAR Selectivity, Activity and Interaction with Cofactors

Structural basis for the cyclophilin A binding affinity and immunosuppressive potency of E-ISA247 (voclosporin)

Fragment-Based Screening Using Surface Plasmon Resonance Technology

Identification of Potent and Selective Cathepsin S Inhibitors Containing Different Central Cyclic Scaffolds

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