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Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle

Neuron (Cambridge, Mass.), 2014-01, Vol.81 (1), p.49-60

2014

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Region-specific permeability of the blood–brain barrier upon pericyte loss

Journal of cerebral blood flow and metabolism, 2017-12, Vol.37 (12), p.3683-3694

2017

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Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood-Brain Barrier

Scientific reports, 2016-05, Vol.6 (1), p.25658-25658, Article 25658

2016

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Separation of Fast from Slow Anabolism by Site-specific PEGylation of Insulin-like Growth Factor I (IGF-I)

The Journal of biological chemistry, 2011-06, Vol.286 (22), p.19501-19510

2011

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Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport

EBioMedicine, 2017-10, Vol.24 (C), p.76-92

2017

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Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span

Neurobiology of disease, 2005-02, Vol.18 (1), p.32-39

2005

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In vitro pharmacological selectivity profile of oseltamivir prodrug (Tamiflu ®) and active metabolite

European journal of pharmacology, 2010-02, Vol.628 (1), p.6-10

2010

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Presenilins Are Processed by Caspase-type Proteases

The Journal of biological chemistry, 1997-08, Vol.272 (33), p.20655-20659

1997

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Is caspase-3 inhibition a valid therapeutic strategy in cerebral ischemia?

Drug Discovery Today, 2001-07, Vol.6 (13), p.671-680

2001

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Amyloidogenic Function of the Alzheimer's Disease-Associated Presenilin 1 in the Absence of Endoproteolysis

Biochemistry (Easton), 1999-11, Vol.38 (44), p.14600-14605

1999

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Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β

Journal of Alzheimer's disease, 2012-01, Vol.28 (1), p.49

2012

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Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor

Cell, 1990-04, Vol.61 (2), p.351-359

1990

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Cargo Delivery into the Brain by in vivo identified Transport Peptides

Scientific reports, 2015-09, Vol.5 (1), p.14104-14104, Article 14104

2015

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Disturbed Cross Talk between Insulin-Like Growth Factor I and AMP-Activated Protein Kinase as a Possible Cause of Vascular Dysfunction in the Amyloid Precursor Protein/Presenilin 2 Mouse Model of Alzheimer's Disease

The Journal of neuroscience, 2007-01, Vol.27 (4), p.824-831

2007

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Mechanism of amyloid removal in patients with Alzheimer disease treated with gantenerumab

Archives of neurology (Chicago), 2012-02, Vol.69 (2), p.198

2012

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Tumor necrosis factor receptors―structure and function

Immunologic research, 1992-01, Vol.11 (2), p.81-90

1992

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Two human TNF receptors have similar extracellular, but distinct intracellular, domain sequences

Cytokine (Philadelphia, Pa.), 1990-07, Vol.2 (4), p.231-237

1990

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PS2APP Transgenic Mice, Coexpressing hPS2mut and hAPPswe, Show Age-Related Cognitive Deficits Associated with Discrete Brain Amyloid Deposition and Inflammation

The Journal of neuroscience, 2003-10, Vol.23 (26), p.8989-9003

2003

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Crystal structure of the novel aspartic proteinase zymogen proplasmepsin II from Plasmodium falciparum

Nature structural biology, 1999-01, Vol.6 (1), p.32-37

1999

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Role of Caspase-3 Activation in Cerebral Ischemia-Induced Neurodegeneration in Adult and Neonatal Brain

Journal of cerebral blood flow and metabolism, 2002-04, Vol.22 (4), p.420-430

2002

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Distribution of BACE1 in the rodent, monkey and human brain

Alzheimer's & dementia, 2012-07, Vol.8 (4), p.P154-P154

2012

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P1‐138: Distribution of BACE1 in the rodent, monkey and human brain

Alzheimer's & dementia, 2012-07, Vol.8 (4S_Part_4), p.P154-P154

2012

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Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation

Cell, 1993-05, Vol.73 (3), p.431-445

1993

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Sembragiline: A Novel, Selective Monoamine Oxidase Type B Inhibitor for the Treatment of Alzheimer's Disease

The Journal of pharmacology and experimental therapeutics, 2017-09, Vol.362 (3), p.413

2017

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Tumor necrosis factor α (TNF-α)-induced cell adhesion to human endothelial cells is under dominant control of one TNF receptor type, TNF-R55

The Journal of experimental medicine, 1993-05, Vol.177 (5), p.1277-1286

1993

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Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle

Region-specific permeability of the blood–brain barrier upon pericyte loss

Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood-Brain Barrier

Separation of Fast from Slow Anabolism by Site-specific PEGylation of Insulin-like Growth Factor I (IGF-I)

Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport

Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span

In vitro pharmacological selectivity profile of oseltamivir prodrug (Tamiflu ®) and active metabolite

Presenilins Are Processed by Caspase-type Proteases

Is caspase-3 inhibition a valid therapeutic strategy in cerebral ischemia?

Amyloidogenic Function of the Alzheimer's Disease-Associated Presenilin 1 in the Absence of Endoproteolysis

Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β

Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor

Cargo Delivery into the Brain by in vivo identified Transport Peptides

Disturbed Cross Talk between Insulin-Like Growth Factor I and AMP-Activated Protein Kinase as a Possible Cause of Vascular Dysfunction in the Amyloid Precursor Protein/Presenilin 2 Mouse Model of Alzheimer's Disease

Mechanism of amyloid removal in patients with Alzheimer disease treated with gantenerumab

Tumor necrosis factor receptors―structure and function

Two human TNF receptors have similar extracellular, but distinct intracellular, domain sequences

PS2APP Transgenic Mice, Coexpressing hPS2mut and hAPPswe, Show Age-Related Cognitive Deficits Associated with Discrete Brain Amyloid Deposition and Inflammation

Crystal structure of the novel aspartic proteinase zymogen proplasmepsin II from Plasmodium falciparum

Role of Caspase-3 Activation in Cerebral Ischemia-Induced Neurodegeneration in Adult and Neonatal Brain

Distribution of BACE1 in the rodent, monkey and human brain

P1‐138: Distribution of BACE1 in the rodent, monkey and human brain

Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation

Sembragiline: A Novel, Selective Monoamine Oxidase Type B Inhibitor for the Treatment of Alzheimer's Disease

Tumor necrosis factor α (TNF-α)-induced cell adhesion to human endothelial cells is under dominant control of one TNF receptor type, TNF-R55

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