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Finding New Tricks For Old Drugs: An Efficient Route For Public-Sector Drug Discovery

Nature reviews. Drug discovery, 2005-12, Vol.4 (12), p.1005-1014

2005

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How Ligands Illuminate GPCR Molecular Pharmacology

Cell, 2017-07, Vol.170 (3), p.414-427

2017

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Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor

Cell, 2018-01, Vol.172 (1-2), p.55-67.e15

2018

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5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology

Cell, 2018-02, Vol.172 (4), p.719-730.e14

2018

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Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization

Nature neuroscience, 2011-01, Vol.14 (1), p.22-24

2011

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Pharmacological characterization of novel synthetic opioids (NSO) found in the recreational drug marketplace

Neuropharmacology, 2018-05, Vol.134 (Pt A), p.101-107

2018

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Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

Nature reviews. Drug discovery, 2004-04, Vol.3 (4), p.353-359

2004

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Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats

Neuropsychopharmacology (New York, N.Y.), 2016-01, Vol.41 (2), p.402-409

2016

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Aripiprazole, A Novel Atypical Antipsychotic Drug with a Unique and Robust Pharmacology

Neuropsychopharmacology, 2003-08, Vol.28 (8), p.1400-1411

2003

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Nigrostriatal Dopaminergic Deficits and Hypokinesia Caused by Inactivation of the Familial Parkinsonism-Linked Gene DJ-1

Neuron (Cambridge, Mass.), 2005-02, Vol.45 (4), p.489-496

2005

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HI-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs

Neuropsychopharmacology (New York, N.Y.), 2003-03, Vol.28 (3), p.519-526

2003

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Conference Report: Psychiatric Genomics Consortium Meeting: Pathways to Drugs, London, March 2017

Biological psychiatry (1969), 2018-09, Vol.84 (6), p.e49-e50

2018

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Evidence for the Preferential Involvement of 5-HT2A Serotonin Receptors in Stress- and Drug-Induced Dopamine Release in the Rat Medial Prefrontal Cortex

Neuropsychopharmacology (New York, N.Y.), 2006-02, Vol.31 (2), p.265-277

2006

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Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression

Biological psychiatry (1969), 1999-05, Vol.45 (9), p.1085-1098

1999

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Involvement of AMPA receptor phosphorylation in antidepressant actions with special reference to tianeptine

The European journal of neuroscience, 2007-12, Vol.26 (12), p.3509-3517

2007

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G protein-coupled receptor (GPCR) trafficking in the central nervous system: relevance for drugs of abuse

Drug and alcohol dependence, 1998-06, Vol.51 (1), p.73-85

1998

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Evidence for possible involvement of 5-HT2B receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications

Circulation (New York, N.Y.), 2000-12, Vol.102 (23), p.2836-2841

2000

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Control of Serotonergic Function in Medial Prefrontal Cortex by Serotonin-2A Receptors through a Glutamate-Dependent Mechanism

The Journal of neuroscience, 2001-12, Vol.21 (24), p.9856-9866

2001

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Localization of 5-HT2A receptors on dopamine cells in subnuclei of the midbrain A10 cell group

Neuroscience, 2002-04, Vol.111 (1), p.163-176

2002

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Salvinorin A: the ‘magic mint’ hallucinogen finds a molecular target in the kappa opioid receptor

Trends in pharmacological sciences (Regular ed.), 2003-03, Vol.24 (3), p.107-109

2003

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Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting

Assay and drug development technologies, 2010-12, Vol.8 (6), p.727-742

2010

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What's all the RAVE about receptor internalization?

Neuron (Cambridge, Mass.), 1999-08, Vol.23 (4), p.629-631

1999

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Design, synthesis and pharmacological activity of new C(2)-modified salvinorin A analogues

Planta medica, 2014, Vol.80 (10)

2014

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New C(2)-sulfonyl ester-type Salvinorin A ligands to the kappa-opioid receptor

Planta medica, 2015, Vol.81 (5)

2015

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Salvinorin A: A novel and highly selective κ-opioid receptor agonist

Life sciences (1973), 2004-10, Vol.75 (22), p.2615-2619

2004

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Finding New Tricks For Old Drugs: An Efficient Route For Public-Sector Drug Discovery

How Ligands Illuminate GPCR Molecular Pharmacology

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor

5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology

Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization

Pharmacological characterization of novel synthetic opioids (NSO) found in the recreational drug marketplace

Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats

Aripiprazole, A Novel Atypical Antipsychotic Drug with a Unique and Robust Pharmacology

Nigrostriatal Dopaminergic Deficits and Hypokinesia Caused by Inactivation of the Familial Parkinsonism-Linked Gene DJ-1

HI-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs

Conference Report: Psychiatric Genomics Consortium Meeting: Pathways to Drugs, London, March 2017

Evidence for the Preferential Involvement of 5-HT2A Serotonin Receptors in Stress- and Drug-Induced Dopamine Release in the Rat Medial Prefrontal Cortex

Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression

Involvement of AMPA receptor phosphorylation in antidepressant actions with special reference to tianeptine

G protein-coupled receptor (GPCR) trafficking in the central nervous system: relevance for drugs of abuse

Evidence for possible involvement of 5-HT2B receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications

Control of Serotonergic Function in Medial Prefrontal Cortex by Serotonin-2A Receptors through a Glutamate-Dependent Mechanism

Localization of 5-HT2A receptors on dopamine cells in subnuclei of the midbrain A10 cell group

Salvinorin A: the ‘magic mint’ hallucinogen finds a molecular target in the kappa opioid receptor

Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting

What's all the RAVE about receptor internalization?

Design, synthesis and pharmacological activity of new C(2)-modified salvinorin A analogues

New C(2)-sulfonyl ester-type Salvinorin A ligands to the kappa-opioid receptor

Salvinorin A: A novel and highly selective κ-opioid receptor agonist

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