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Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

Journal of the American Chemical Society, 2014-03, Vol.136 (12), p.4551-4556

2014

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Biological metals and metal-targeting compounds in major neurodegenerative diseases

Chemical Society reviews, 2014-01, Vol.43 (19), p.6727-6749

2014

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Selenium Nanoparticles as an Efficient Nanomedicine for the Therapy of Huntington’s Disease

ACS applied materials & interfaces, 2019-09, Vol.11 (38), p.34725-34735

2019

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Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington’s disease

Nature (London), 2014-05, Vol.509 (7498), p.96-100

2014

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Small molecule splicing modifiers with systemic HTT-lowering activity

Nature communications, 2021-12, Vol.12 (1), p.7299-7299, Article 7299

2021

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An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion

Nature communications, 2022-03, Vol.13 (1), p.1150-1150, Article 1150

2022

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Restoring GABAergic inhibition rescues memory deficits in a Huntington’s disease mouse model

Proceedings of the National Academy of Sciences - PNAS, 2018-02, Vol.115 (7), p.E1618-E1626

2018

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TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington’s disease

Proceedings of the National Academy of Sciences - PNAS, 2016-09, Vol.113 (38), p.E5655-E5664

2016

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Discovery of Small Molecules that Induce the Degradation of Huntingtin

Angewandte Chemie International Edition, 2017-09, Vol.56 (38), p.11530-11533

International ed. in English, 2017

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An alternative splicing modulator decreases mutant HTT and improves the molecular fingerprint in Huntington’s disease patient neurons

Nature communications, 2022-11, Vol.13 (1), p.6797-14, Article 6797

2022

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Therapeutic Effect of Berberine on Huntington's Disease Transgenic Mouse Model

PloS one, 2015-07, Vol.10 (7), p.e0134142-e0134142

2015

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Apathy and Depression in Huntington’s Disease: Distinct Longitudinal Trajectories and Clinical Correlates

The journal of neuropsychiatry and clinical neurosciences, 2023-01, Vol.35 (1), p.69-76

2023

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Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntington's disease

Proceedings of the National Academy of Sciences - PNAS, 2024-09, Vol.121 (39), p.e2406308121

2024

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6-shogaol against 3-Nitropropionic acid-induced Huntington's disease in rodents: Based on molecular docking/targeting pro-inflammatory cytokines/NF-κB-BDNF-Nrf2 pathway

PloS one, 2024-07, Vol.19 (7), p.e0305358

2024

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Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide

Proceedings of the National Academy of Sciences - PNAS, 2022-03, Vol.119 (10), p.e2114303119-e2114303119

2022

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Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington’s disease

Scientific reports, 2017-07, Vol.7 (1), p.5280-14, Article 5280

2017

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Agmatine mitigates behavioral abnormalities and neurochemical dysregulation associated with 3-Nitropropionic acid-induced Huntington's disease in rats

Neurotoxicology (Park Forest South), 2024-05, Vol.102, p.12-28

2024

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HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation

Proceedings of the National Academy of Sciences - PNAS, 2015-01, Vol.112 (1), p.E56-E64

2015

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Early epigenomic and transcriptional changes reveal Elk-1 transcription factor as a therapeutic target in Huntington’s disease

Proceedings of the National Academy of Sciences - PNAS, 2019-12, Vol.116 (49), p.24840-24851

2019

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N6-Furfuryladenine is protective in Huntington’s disease models by signaling huntingtin phosphorylation

Proceedings of the National Academy of Sciences - PNAS, 2018-07, Vol.115 (30), p.E7081-E7090

2018

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Combination therapy with Coenzyme Q₁₀ and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's Diseases

Journal of neurochemistry, 2009-06, Vol.109 (5), p.1427-1439

2009

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Discovery of a potent small molecule inhibiting Huntington’s disease (HD) pathogenesis via targeting CAG repeats RNA and Poly Q protein

Scientific reports, 2019-11, Vol.9 (1), p.16872-15, Article 16872

2019

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Fragment-based virtual screening identifies a first-in-class preclinical drug candidate for Huntington’s disease

Scientific reports, 2022-11, Vol.12 (1), p.19642-19642, Article 19642

2022

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PARP-1 Inhibition Is Neuroprotective in the R6/2 Mouse Model of Huntington's Disease

PloS one, 2015-08, Vol.10 (8), p.e0134482-e0134482

2015

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Metformin intake associates with better cognitive function in patients with Huntington's disease

PloS one, 2017-06, Vol.12 (6), p.e0179283

2017

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Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

Biological metals and metal-targeting compounds in major neurodegenerative diseases

Selenium Nanoparticles as an Efficient Nanomedicine for the Therapy of Huntington’s Disease

Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington’s disease

Small molecule splicing modifiers with systemic HTT-lowering activity

An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion

Restoring GABAergic inhibition rescues memory deficits in a Huntington’s disease mouse model

TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington’s disease

Discovery of Small Molecules that Induce the Degradation of Huntingtin

An alternative splicing modulator decreases mutant HTT and improves the molecular fingerprint in Huntington’s disease patient neurons

Therapeutic Effect of Berberine on Huntington's Disease Transgenic Mouse Model

Apathy and Depression in Huntington’s Disease: Distinct Longitudinal Trajectories and Clinical Correlates

Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntington's disease

6-shogaol against 3-Nitropropionic acid-induced Huntington's disease in rodents: Based on molecular docking/targeting pro-inflammatory cytokines/NF-κB-BDNF-Nrf2 pathway

Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide

Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington’s disease

Agmatine mitigates behavioral abnormalities and neurochemical dysregulation associated with 3-Nitropropionic acid-induced Huntington's disease in rats

HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation

Early epigenomic and transcriptional changes reveal Elk-1 transcription factor as a therapeutic target in Huntington’s disease

N6-Furfuryladenine is protective in Huntington’s disease models by signaling huntingtin phosphorylation

Combination therapy with Coenzyme Q₁₀ and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's Diseases

Discovery of a potent small molecule inhibiting Huntington’s disease (HD) pathogenesis via targeting CAG repeats RNA and Poly Q protein

Fragment-based virtual screening identifies a first-in-class preclinical drug candidate for Huntington’s disease

PARP-1 Inhibition Is Neuroprotective in the R6/2 Mouse Model of Huntington's Disease

Metformin intake associates with better cognitive function in patients with Huntington's disease

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