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Catabolic fate and pharmacokinetic characterization of trastuzumab emtansine (T-DM1): an emphasis on preclinical and clinical catabolism

Current drug metabolism, 2012-09, Vol.13 (7), p.901-910

2012

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Microtubule and tubulin binding and regulation of microtubule dynamics by the antibody drug conjugate (ADC) payload, monomethyl auristatin E (MMAE): Mechanistic insights into MMAE ADC peripheral neuropathy

Toxicology and applied pharmacology, 2021-06, Vol.421, p.115534, Article 115534

2021

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Clinical pharmacology strategies to accelerate the development of polatuzumab vedotin and summary of key findings

Advanced drug delivery reviews, 2024-04, Vol.207, p.115193, Article 115193

2024

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Vascular Endothelial Growth Factor Governs Endothelial Nitric-oxide Synthase Expression via a KDR/Flk-1 Receptor and a Protein Kinase C Signaling Pathway

The Journal of biological chemistry, 1999-11, Vol.274 (46), p.33057-33063

1999

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Non-Clinical Disposition and Metabolism of DM1, a Component of Trastuzumab Emtansine (T-DM1), in Sprague Dawley Rats

Drug metabolism letters, 2015-11, Vol.9 (2), p.119-131

2015

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Characterization of Tissue Distribution, Catabolism, and Elimination of an Anti- Staphylococcus aureus THIOMAB Antibody-Antibiotic Conjugate in Rats

Drug metabolism and disposition, 2020-11, Vol.48 (11), p.1161-1168

2020

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Utilizing PK and PD Biomarkers to Guide the First-in-Human Starting Dose Selection of MTBT1466A: A Novel Humanized Monoclonal Anti-TGFβ3 Antibody for the Treatment of Fibrotic Diseases

Journal of pharmaceutical sciences, 2023-11, Vol.112 (11), p.2910-2920

2023

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Homologous Up-regulation of KDR/Flk-1 Receptor Expression by Vascular Endothelial Growth Factor in Vitro

The Journal of biological chemistry, 1998-11, Vol.273 (45), p.29979-29985

1998

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A novel approach to quantitate biodistribution and transduction of adeno-associated virus gene therapy using radiolabeled AAV vectors in mice

Molecular therapy. Methods & clinical development, 2024-09, Vol.32 (3), p.101326, Article 101326

2024

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Preclinical Characterization of the Distribution, Catabolism, and Elimination of a Polatuzumab Vedotin-Piiq (POLIVY ® ) Antibody-Drug Conjugate in Sprague Dawley Rats

Journal of clinical medicine, 2021-03, Vol.10 (6), p.1323

2021

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Preclinical pharmacokinetics and pharmacodynamics of DCLL9718A: An antibody-drug conjugate for the treatment of acute myeloid leukemia

mAbs, 2018-11, Vol.10 (8), p.1312-1321

2018

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Monomethyl Auristatin E (MMAE), a Payload for Multiple Antibody Drug Conjugates (ADCs), Demonstrates Differential Red Blood Cell Partitioning Across Human and Animal Species

Xenobiotica, 2024-09, Vol.54 (8), p.1-520

2024

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Exaggerated Hypotensive Effect of Vascular Endothelial Growth Factor in Spontaneously Hypertensive Rats

Hypertension (Dallas, Tex. 1979), 2002-03, Vol.39 (3), p.815-820

2002

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Anti-Lymphocyte Antigen 6 Complex, Locus E- Seco -Cyclopropabenzindol-4-One-Dimer Antibody-Drug Conjugate That Forms Adduct with α 1-Microglobulin Demonstrates Slower Systemic Antibody Clearance and Reduced Tumor Distribution in Animals

Drug metabolism and disposition, 2020-12, Vol.48 (12), p.1247-1256

2020

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Abstract LB242: Characterizing the fate<tissue distribution and excretion route> of cancer vaccine lipoplex-RNA following intravenous injection of 14C-DOTMA-lipoplex-mRNA in mice

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (8_Supplement), p.LB242-LB242

2023

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Abstract A136: Nonclinical disposition, metabolism, and in vitro drug-drug interaction assessment of DM1, a component of trastuzumab emtansine (T-DM1)

Molecular cancer therapeutics, 2011-11, Vol.10 (11_Supplement), p.A136-A136

2011

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Non-Clinical Disposition and Metabolism of DM1, a Component of Trastuzumab Emtansine (T-DM1), in Sprague Dawley Rats

Drug metabolism letters, 2015, Vol.9 (2), p.119

2015

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Abstract 696: Anti-NRP1 tumor uptake is impacted by normal tissue sinks in a tumor bearing mouse model

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.696-696

2010

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Abstract 4396: Conjugation site modulates the stability and biological activity of antibody drug conjugates

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.4396-4396

2010

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Pharmacokinetics of Anti-CD22 Antibody Conjugates with Uncleavable and Cleavable Linkers in Rats

Blood, 2007-11, Vol.110 (11), p.2361-2361

2007

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Effects of lovastatin on trafficking of cystic fibrosis transmembrane conductance regulator in human tracheal epithelium

The Journal of biological chemistry, 1996-01, Vol.271 (2), p.1250-1250

1996

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Hepatocyte growth factor stimulates the differentiation of human tracheal epithelia in vitro

American journal of physiology. Lung cellular and molecular physiology, 1997-06, Vol.16 (6), p.L1115-L1120

1997

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Preclinical pharmacokinetics and pharmacodynamics of DCLL9718A: An antibody-drug conjugate for the treatment of acute myeloid leukemia

mAbs, 2018, Vol.10 (8), p.1312-1321

2018

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Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice

mAbs, 2014, Vol.6 (6), p.1631-1637

2014

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A homogeneous high-DAR antibody-drug conjugate platform combining THIOMAB antibodies and XTEN polypeptides

Catabolic fate and pharmacokinetic characterization of trastuzumab emtansine (T-DM1): an emphasis on preclinical and clinical catabolism

Microtubule and tubulin binding and regulation of microtubule dynamics by the antibody drug conjugate (ADC) payload, monomethyl auristatin E (MMAE): Mechanistic insights into MMAE ADC peripheral neuropathy

Clinical pharmacology strategies to accelerate the development of polatuzumab vedotin and summary of key findings

Vascular Endothelial Growth Factor Governs Endothelial Nitric-oxide Synthase Expression via a KDR/Flk-1 Receptor and a Protein Kinase C Signaling Pathway

Non-Clinical Disposition and Metabolism of DM1, a Component of Trastuzumab Emtansine (T-DM1), in Sprague Dawley Rats

Characterization of Tissue Distribution, Catabolism, and Elimination of an Anti- Staphylococcus aureus THIOMAB Antibody-Antibiotic Conjugate in Rats

Utilizing PK and PD Biomarkers to Guide the First-in-Human Starting Dose Selection of MTBT1466A: A Novel Humanized Monoclonal Anti-TGFβ3 Antibody for the Treatment of Fibrotic Diseases

Homologous Up-regulation of KDR/Flk-1 Receptor Expression by Vascular Endothelial Growth Factor in Vitro

A novel approach to quantitate biodistribution and transduction of adeno-associated virus gene therapy using radiolabeled AAV vectors in mice

Preclinical Characterization of the Distribution, Catabolism, and Elimination of a Polatuzumab Vedotin-Piiq (POLIVY ® ) Antibody-Drug Conjugate in Sprague Dawley Rats

Preclinical pharmacokinetics and pharmacodynamics of DCLL9718A: An antibody-drug conjugate for the treatment of acute myeloid leukemia

Monomethyl Auristatin E (MMAE), a Payload for Multiple Antibody Drug Conjugates (ADCs), Demonstrates Differential Red Blood Cell Partitioning Across Human and Animal Species

Exaggerated Hypotensive Effect of Vascular Endothelial Growth Factor in Spontaneously Hypertensive Rats

Anti-Lymphocyte Antigen 6 Complex, Locus E- Seco -Cyclopropabenzindol-4-One-Dimer Antibody-Drug Conjugate That Forms Adduct with α 1-Microglobulin Demonstrates Slower Systemic Antibody Clearance and Reduced Tumor Distribution in Animals

Abstract LB242: Characterizing the fate<tissue distribution and excretion route> of cancer vaccine lipoplex-RNA following intravenous injection of 14C-DOTMA-lipoplex-mRNA in mice

Abstract A136: Nonclinical disposition, metabolism, and in vitro drug-drug interaction assessment of DM1, a component of trastuzumab emtansine (T-DM1)

Non-Clinical Disposition and Metabolism of DM1, a Component of Trastuzumab Emtansine (T-DM1), in Sprague Dawley Rats

Abstract 696: Anti-NRP1 tumor uptake is impacted by normal tissue sinks in a tumor bearing mouse model

Abstract 4396: Conjugation site modulates the stability and biological activity of antibody drug conjugates

Pharmacokinetics of Anti-CD22 Antibody Conjugates with Uncleavable and Cleavable Linkers in Rats

Effects of lovastatin on trafficking of cystic fibrosis transmembrane conductance regulator in human tracheal epithelium

Hepatocyte growth factor stimulates the differentiation of human tracheal epithelia in vitro

Preclinical pharmacokinetics and pharmacodynamics of DCLL9718A: An antibody-drug conjugate for the treatment of acute myeloid leukemia

Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice

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