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Cancer Selective Target Degradation by Folate-Caged PROTACs

Journal of the American Chemical Society, 2021-05, Vol.143 (19), p.7380-7387

2021

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Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2

Science (American Association for the Advancement of Science), 2021-08, Vol.373 (6557), p.931-936

2021

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Seed coating with a neonicotinoid insecticide negatively affects wild bees

Nature (London), 2015-05, Vol.521 (7550), p.77-80

2015

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Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

Cell metabolism, 2015-01, Vol.21 (1), p.33-38

2015

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Bees prefer foods containing neonicotinoid pesticides

Nature (London), 2015-05, Vol.521 (7550), p.74-76

2015

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Thiazoles and Thiazolidinones as COX/LOX Inhibitors

Molecules (Basel, Switzerland), 2018-03, Vol.23 (3), p.685

2018

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Direct oral anticoagulants: evidence and unresolved issues

The Lancet (British edition), 2020-11, Vol.396 (10264), p.1767-1776

2020

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An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives

Molecules (Basel, Switzerland), 2021-01, Vol.26 (3), p.624

2021

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Sphingosine 1-phosphate receptor modulators in multiple sclerosis and other conditions

The Lancet (British edition), 2021-09, Vol.398 (10306), p.1184-1194

2021

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Thiazole Ring-A Biologically Active Scaffold

Molecules (Basel, Switzerland), 2021-05, Vol.26 (11), p.3166

2021

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Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S,4R)‑1-((S)‑2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy‑N‑(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)

Journal of medicinal chemistry, 2018-01, Vol.61 (2), p.599-618

2018

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Using Graphene Oxide High Near-Infrared Absorbance for Photothermal Treatment of Alzheimer's Disease

Advanced materials (Weinheim), 2012-04, Vol.24 (13), p.1722-1728

2012

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Thiazolyl-pyrazoline derivatives: In vitro and in silico evaluation as potential acetylcholinesterase and carbonic anhydrase inhibitors

International journal of biological macromolecules, 2020-11, Vol.163, p.1970-1988

2020

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Discovery of thiazole-based-chalcones and 4-hetarylthiazoles as potent anticancer agents: Synthesis, docking study and anticancer activity

Bioorganic chemistry, 2020-05, Vol.98, p.103761, Article 103761

2020

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Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor

Nature (London), 2015-02, Vol.518 (7538), p.240-244

2015

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Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation

Nature chemical biology, 2018-02, Vol.14 (2), p.163

2018

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Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

Nature communications, 2016-11, Vol.7 (1), p.13312-13312, Article 13312

2016

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Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor

Cancer discovery, 2019-07, Vol.9 (7), p.926-943

2019

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Lusutrombopag: First Global Approval

Drugs (New York, N.Y.), 2016-01, Vol.76 (1), p.155-158

Kim, Esther S.

2016

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Selective Sirt2 inhibition by ligand-induced rearrangement of the active site

Nature communications, 2015-02, Vol.6 (1), p.6263-6263, Article 6263

2015

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Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors

Nature (London), 2016-06, Vol.534 (7605), p.129-132

2016

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Pulmonary Arterial Hypertension in Patients Treated by Dasatinib

Circulation (New York, N.Y.), 2012-05, Vol.125 (17), p.2128-2137

2012

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Cancer Selective Target Degradation by Folate-Caged PROTACs

Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2

Seed coating with a neonicotinoid insecticide negatively affects wild bees

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

Bees prefer foods containing neonicotinoid pesticides

Thiazoles and Thiazolidinones as COX/LOX Inhibitors

FDA Approval Summary: Alpelisib Plus Fulvestrant for Patients with HR-positive, HER2-negative, PIK3CA-mutated, Advanced or Metastatic Breast Cancer

Direct oral anticoagulants: evidence and unresolved issues

An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives

Sphingosine 1-phosphate receptor modulators in multiple sclerosis and other conditions

Thiazole Ring-A Biologically Active Scaffold

Using Graphene Oxide High Near-Infrared Absorbance for Photothermal Treatment of Alzheimer's Disease

Thiazolyl-pyrazoline derivatives: In vitro and in silico evaluation as potential acetylcholinesterase and carbonic anhydrase inhibitors

Discovery of thiazole-based-chalcones and 4-hetarylthiazoles as potent anticancer agents: Synthesis, docking study and anticancer activity

Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor

Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor

Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials

Lusutrombopag: First Global Approval

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site

Ponesimod Compared With Teriflunomide in Patients With Relapsing Multiple Sclerosis in the Active-Comparator Phase 3 OPTIMUM Study: A Randomized Clinical Trial

Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors

Pulmonary Arterial Hypertension in Patients Treated by Dasatinib

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