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Cancer Selective Target Degradation by Folate-Caged PROTACs

Journal of the American Chemical Society, 2021-05, Vol.143 (19), p.7380-7387

2021

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Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2

Science (American Association for the Advancement of Science), 2021-08, Vol.373 (6557), p.931-936

2021

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Seed coating with a neonicotinoid insecticide negatively affects wild bees

Nature (London), 2015-05, Vol.521 (7550), p.77-80

2015

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Bees prefer foods containing neonicotinoid pesticides

Nature (London), 2015-05, Vol.521 (7550), p.74-76

2015

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Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

Cell metabolism, 2015-01, Vol.21 (1), p.33-38

2015

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An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives

Molecules (Basel, Switzerland), 2021-01, Vol.26 (3), p.624

2021

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Thiazoles and Thiazolidinones as COX/LOX Inhibitors

Molecules (Basel, Switzerland), 2018-03, Vol.23 (3), p.685

2018

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Thiazole Ring-A Biologically Active Scaffold

Molecules (Basel, Switzerland), 2021-05, Vol.26 (11), p.3166

2021

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Sphingosine 1-phosphate receptor modulators in multiple sclerosis and other conditions

The Lancet (British edition), 2021-09, Vol.398 (10306), p.1184-1194

2021

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Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S,4R)‑1-((S)‑2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy‑N‑(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)

Journal of medicinal chemistry, 2018-01, Vol.61 (2), p.599-618

2018

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Direct oral anticoagulants: evidence and unresolved issues

The Lancet (British edition), 2020-11, Vol.396 (10264), p.1767-1776

2020

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Using Graphene Oxide High Near-Infrared Absorbance for Photothermal Treatment of Alzheimer's Disease

Advanced materials (Weinheim), 2012-04, Vol.24 (13), p.1722-1728

2012

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Thiazolyl-pyrazoline derivatives: In vitro and in silico evaluation as potential acetylcholinesterase and carbonic anhydrase inhibitors

International journal of biological macromolecules, 2020-11, Vol.163, p.1970-1988

2020

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Selective Sirt2 inhibition by ligand-induced rearrangement of the active site

Nature communications, 2015-02, Vol.6 (1), p.6263-6263, Article 6263

2015

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Discovery of thiazole-based-chalcones and 4-hetarylthiazoles as potent anticancer agents: Synthesis, docking study and anticancer activity

Bioorganic chemistry, 2020-05, Vol.98, p.103761, Article 103761

2020

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Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor

Nature (London), 2015-02, Vol.518 (7538), p.240-244

2015

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Synthesis, DFT Studies, Molecular Docking and Biological Activity Evaluation of Thiazole-Sulfonamide Derivatives as Potent Alzheimer's Inhibitors

Molecules (Basel, Switzerland), 2023-01, Vol.28 (2), p.559

2023

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Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation

Nature chemical biology, 2018-02, Vol.14 (2), p.163-170

2018

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Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor

Cancer discovery, 2019-07, Vol.9 (7), p.926-943

2019

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Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

Nature communications, 2016-11, Vol.7 (1), p.13312-12, Article 13312

2016

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Ponesimod Compared With Teriflunomide in Patients With Relapsing Multiple Sclerosis in the Active-Comparator Phase 3 OPTIMUM Study: A Randomized Clinical Trial

JAMA neurology, 2021-05, Vol.78 (5), p.558

2021

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Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials

Molecular cancer therapeutics, 2014-05, Vol.13 (5), p.1117-1129

2014

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Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel

Neuron (Cambridge, Mass.), 2020-03, Vol.105 (5), p.882-894.e5

2020

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Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors

Nature (London), 2016-06, Vol.534 (7605), p.129-132

2016

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Cancer Selective Target Degradation by Folate-Caged PROTACs

Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2

Seed coating with a neonicotinoid insecticide negatively affects wild bees

Bees prefer foods containing neonicotinoid pesticides

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

FDA Approval Summary: Alpelisib Plus Fulvestrant for Patients with HR-positive, HER2-negative, PIK3CA-mutated, Advanced or Metastatic Breast Cancer

An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives

Thiazoles and Thiazolidinones as COX/LOX Inhibitors

Thiazole Ring-A Biologically Active Scaffold

Sphingosine 1-phosphate receptor modulators in multiple sclerosis and other conditions

Direct oral anticoagulants: evidence and unresolved issues

Using Graphene Oxide High Near-Infrared Absorbance for Photothermal Treatment of Alzheimer's Disease

Thiazolyl-pyrazoline derivatives: In vitro and in silico evaluation as potential acetylcholinesterase and carbonic anhydrase inhibitors

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site

Discovery of thiazole-based-chalcones and 4-hetarylthiazoles as potent anticancer agents: Synthesis, docking study and anticancer activity

Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor

Synthesis, DFT Studies, Molecular Docking and Biological Activity Evaluation of Thiazole-Sulfonamide Derivatives as Potent Alzheimer's Inhibitors

Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation

Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

Ponesimod Compared With Teriflunomide in Patients With Relapsing Multiple Sclerosis in the Active-Comparator Phase 3 OPTIMUM Study: A Randomized Clinical Trial

Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials

Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel

Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors

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