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Allele-Specific Mechanisms of Activation of MEK1 Mutants Determine Their Properties

Cancer discovery, 2018-05, Vol.8 (5), p.648-661

2018

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Role of Raf-like kinases in SnRK2 activation and osmotic stress response in plants

Nature communications, 2020-12, Vol.11 (1), p.6184-6184, Article 6184

2020

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A Structure is Worth a Thousand Words: New Insights for RAS and RAF Regulation

Cancer discovery, 2022-04, Vol.12 (4), p.899-912

2022

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Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations

Molecular cancer research, 2015-09, Vol.13 (9), p.1325-1335

2015

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Ras-Mediated Activation of the Raf Family Kinases

Cold Spring Harbor perspectives in medicine, 2019-01, Vol.9 (1), p.a033746

2019

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Stochastic ERK activation induced by noise and cell-to-cell propagation regulates cell density-dependent proliferation

Molecular cell, 2013-11, Vol.52 (4), p.529-540

2013

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A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas

Neuro-oncology (Charlottesville, Va.), 2017-06, Vol.19 (6), p.774-785

2017

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KLF4 is regulated by RAS/RAF/MEK/ERK signaling through E2F1 and promotes melanoma cell growth

Oncogene, 2017-06, Vol.36 (23), p.3322-3333

2017

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Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells

Cancer letters, 2017-11, Vol.408, p.73-81

2017

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Effects of Raf Dimerization and Its Inhibition on Normal and Disease-Associated Raf Signaling

Molecular cell, 2013-02, Vol.49 (4), p.751-758

2013

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Kinases and Pseudokinases: Lessons from RAF

Molecular and cellular biology, 2014-05, Vol.34 (9), p.1538-1546

2014

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G protein-coupled receptor 37 is a negative regulator of oligodendrocyte differentiation and myelination

Nature communications, 2016-03, Vol.7 (1), p.10884-10884, Article 10884

2016

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Raf/MEK/ERK can regulate cellular levels of LC3B and SQSTM1/p62 at expression levels

Experimental cell research, 2014-10, Vol.327 (2), p.340-352

2014

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Molecular recognition of RAS/RAF complex at the membrane: Role of RAF cysteine-rich domain

Scientific reports, 2018-05, Vol.8 (1), p.8461-15, Article 8461

2018

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{V600E} BRAF$is Associated with Disabled Feedback Inhibition of RAF–MEK Signaling and Elevated Transcriptional Output of the Pathway

Proceedings of the National Academy of Sciences - PNAS, 2009-03, Vol.106 (11), p.4519-4524

2009

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Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling

Nature (London), 2016-09, Vol.537 (7618), p.112-116

2016

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Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways

Journal of cellular physiology, 2011-11, Vol.226 (11), p.2762-2781

2011

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Regulation of RAF family kinases: new insights from recent structural and biochemical studies

Biochemical Society transactions, 2024-06, Vol.52 (3), p.1061-1069

2024

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Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance

Biochimica et biophysica acta, 2007-08, Vol.1773 (8), p.1263-1284

2007

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Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies

Signal transduction and targeted therapy, 2023-12, Vol.8 (1), p.455-455, Article 455

2023

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Novel RAF‐directed approaches to overcome current clinical limits and block the RAS/RAF node

Molecular oncology, 2024-06, Vol.18 (6), p.1355-1377

2024

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Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling

Proceedings of the National Academy of Sciences - PNAS, 2017-01, Vol.114 (3), p.E317-E326

2017

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Pan-RAF:MEK Molecular Glues Take Center Stage

Cancer discovery, 2024-07, Vol.14 (7), p.1143-1144

2024

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PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation

Cell reports (Cambridge), 2018-10, Vol.25 (3), p.690-701.e8

2018

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Allele-Specific Mechanisms of Activation of MEK1 Mutants Determine Their Properties

Role of Raf-like kinases in SnRK2 activation and osmotic stress response in plants

A Structure is Worth a Thousand Words: New Insights for RAS and RAF Regulation

Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations

Ras-Mediated Activation of the Raf Family Kinases

Stochastic ERK activation induced by noise and cell-to-cell propagation regulates cell density-dependent proliferation

A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas

KLF4 is regulated by RAS/RAF/MEK/ERK signaling through E2F1 and promotes melanoma cell growth

Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells

Effects of Raf Dimerization and Its Inhibition on Normal and Disease-Associated Raf Signaling

Kinases and Pseudokinases: Lessons from RAF

G protein-coupled receptor 37 is a negative regulator of oligodendrocyte differentiation and myelination

Raf/MEK/ERK can regulate cellular levels of LC3B and SQSTM1/p62 at expression levels

Molecular recognition of RAS/RAF complex at the membrane: Role of RAF cysteine-rich domain

{V600E} BRAF$is Associated with Disabled Feedback Inhibition of RAF–MEK Signaling and Elevated Transcriptional Output of the Pathway

Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling

Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways

Regulation of RAF family kinases: new insights from recent structural and biochemical studies

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance

Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies

Novel RAF‐directed approaches to overcome current clinical limits and block the RAS/RAF node

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling

Pan-RAF:MEK Molecular Glues Take Center Stage

PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation

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