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Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late I Nai), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic Properties

Journal of medicinal chemistry, 2016-10, Vol.59 (19), p.9005-9017

2016

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Drug Annotations Series Change in Guidelines

Journal of medicinal chemistry, 2019-03, Vol.62 (5), p.2217-2217

2019

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Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII)

Bioorganic & medicinal chemistry letters, 2018-02, Vol.28 (3), p.541-546

2018

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Structure-affinity relationships of the affinity of 2-pyrazolyl adenosine analogues for the adenosine A2A receptor

Bioorganic & medicinal chemistry letters, 2002-10, Vol.12 (20), p.2935-2939

2002

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Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late I Na i) of the cardiac Na V 1.5 channel with improved efficacy and potency relative to ranolazine

Bioorganic & medicinal chemistry letters, 2016-07, Vol.26 (13), p.3202-3206

2016

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Discovery of triazolopyridinone GS-462808, a late sodium current inhibitor (Late I Na i) of the cardiac Na v 1.5 channel with improved efficacy and potency relative to ranolazine

Bioorganic & medicinal chemistry letters, 2016-07, Vol.26 (13), p.3207-3211

2016

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Partial A1 Adenosine Receptor Agonists from a Molecular Perspective and Their Potential Use as Chronic Ventricular Rate Control Agents During Atrial Fibrillation (AF)

Current topics in medicinal chemistry, 2004-04, Vol.4 (8), p.839-854

2004

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Using Patchxpress to Screen Blockers of the Cardiac Sodium Channel (Nav1.5) for Effects on Late INA, Peak INA, and Channel Kinetics

Biophysical journal, 2010-01, Vol.98 (3), p.113a-113a

2010

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Affinity and intrinsic efficacy (IE) of 5′-carbamoyl adenosine analogues for the A 1 adenosine receptor—efforts towards the discovery of a chronic ventricular rate control agent for the treatment of atrial fibrillation (AF)

Bioorganic & medicinal chemistry letters, 2004, Vol.14 (2), p.535-539

2004

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Structure–affinity relationships of 5 ′ -aromatic ethers and 5 ′ -aromatic sulfides as partial A 1 adenosine agonists, potential supraventricular anti-arrhythmic agents

Bioorganic & medicinal chemistry letters, 2004-07, Vol.14 (14), p.3793-3797

2004

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CVT-4325: A Potent Fatty Acid Oxidation Inhibitor with Favorable Oral Bioavailability

ChemInform, 2005-04, Vol.36 (15), p.no-no

2005

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Structure‐Affinity Relationships of the Affinity of 2‐Pyrazolyl Adenosine Analogues for the Adenosine A 2A Receptor

ChemInform, 2003-02, Vol.34 (8)

2003

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Structure-Affinity Relationships of the Affinity of 2-Pyrazolyl Adenosine Analogues for the Adenosine A2A Receptor

ChemInform, 2003-02, Vol.34 (8), p.no-no

2003

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Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi

Bioorganic & medicinal chemistry letters, 2019-08, Vol.29 (16), p.2428-2436

2019

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The Drug Annotations Series

Journal of medicinal chemistry, 2013-09, Vol.56 (17), p.6541-6541

2013

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Molecule Evoluator CIDRUX BV, Park Oosterspaarn 6, 2036 MB Haarlem, The Netherlands. www. cidrux.com. See Web site for pricing information

Journal of the American Chemical Society, 2007-10, Vol.129 (41), p.12586-12586

Zablocki, Jeff

2007

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Marked difference in saxitoxin and tetrodoxin affinity for the human nociceptive voltage-gated sodium channel (Naᵥ1.7)

Proceedings of the National Academy of Sciences - PNAS, 2012-10, Vol.109 (44), p.18102-18107

2012

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How Can Rates of Prostate-Specific Antigen Screening Be Reduced in Men Aged 80 and Older?

Journal of the American Geriatrics Society (JAGS), 2010-04, Vol.58 (4), p.757-759

2010

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Preface: special issue on medicinal chemistry of purines

Purinergic signalling, 2009-03, Vol.5 (1), p.1-1

2009

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The novel late Na super(+) current inhibitor, GS-6615 (eleclazine) and its anti-arrhythmic effects in rabbit isolated heart preparations

British journal of pharmacology, 2016-11, Vol.173 (21), p.3088-3098

2016

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A 1 adenosine receptor agonists and their potential therapeutic applications

Expert opinion on investigational drugs, 2008-12, Vol.17 (12), p.1901-1910

2008

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Progress in the discovery of selective, high affinity A2B adenosine receptor antagonists as clinical candidates

Purinergic signalling, 2009, Vol.5 (1), p.21-29

2009

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Progress in the discovery of selective, high affinity A(2B) adenosine receptor antagonists as clinical candidates

Purinergic signalling, 2009-03, Vol.5 (1), p.21-29

2009

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Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Nav1.7)

Proceedings of the National Academy of Sciences - PNAS, 2012-10, Vol.109 (44), p.18102-18107

2012

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The discovery of a selective, high affinity A(2B) adenosine receptor antagonist for the potential treatment of asthma

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (3), p.609-612

2005

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Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late I Nai), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic Properties

Drug Annotations Series Change in Guidelines

Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII)

Structure-affinity relationships of the affinity of 2-pyrazolyl adenosine analogues for the adenosine A2A receptor

Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late I Na i) of the cardiac Na V 1.5 channel with improved efficacy and potency relative to ranolazine

Discovery of triazolopyridinone GS-462808, a late sodium current inhibitor (Late I Na i) of the cardiac Na v 1.5 channel with improved efficacy and potency relative to ranolazine

Partial A1 Adenosine Receptor Agonists from a Molecular Perspective and Their Potential Use as Chronic Ventricular Rate Control Agents During Atrial Fibrillation (AF)

Using Patchxpress to Screen Blockers of the Cardiac Sodium Channel (Nav1.5) for Effects on Late INA, Peak INA, and Channel Kinetics

Affinity and intrinsic efficacy (IE) of 5′-carbamoyl adenosine analogues for the A 1 adenosine receptor—efforts towards the discovery of a chronic ventricular rate control agent for the treatment of atrial fibrillation (AF)

Structure–affinity relationships of 5 ′ -aromatic ethers and 5 ′ -aromatic sulfides as partial A 1 adenosine agonists, potential supraventricular anti-arrhythmic agents

CVT-4325: A Potent Fatty Acid Oxidation Inhibitor with Favorable Oral Bioavailability

Structure‐Affinity Relationships of the Affinity of 2‐Pyrazolyl Adenosine Analogues for the Adenosine A 2A Receptor

Structure-Affinity Relationships of the Affinity of 2-Pyrazolyl Adenosine Analogues for the Adenosine A2A Receptor

Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi

The Drug Annotations Series

Molecule Evoluator CIDRUX BV, Park Oosterspaarn 6, 2036 MB Haarlem, The Netherlands. www. cidrux.com. See Web site for pricing information

Marked difference in saxitoxin and tetrodoxin affinity for the human nociceptive voltage-gated sodium channel (Naᵥ1.7)

How Can Rates of Prostate-Specific Antigen Screening Be Reduced in Men Aged 80 and Older?

Preface: special issue on medicinal chemistry of purines

The novel late Na super(+) current inhibitor, GS-6615 (eleclazine) and its anti-arrhythmic effects in rabbit isolated heart preparations

A 1 adenosine receptor agonists and their potential therapeutic applications

Progress in the discovery of selective, high affinity A2B adenosine receptor antagonists as clinical candidates

Progress in the discovery of selective, high affinity A(2B) adenosine receptor antagonists as clinical candidates

Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Nav1.7)

The discovery of a selective, high affinity A(2B) adenosine receptor antagonist for the potential treatment of asthma

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