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Selective activation of the M₁ muscarinic acetylcholine receptor achieved by allosteric potentiation

Proceedings of the National Academy of Sciences - PNAS, 2009-09, Vol.106 (37), p.15950-15955

2009

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Dual Leucine Zipper Kinase Is Constitutively Active in the Adult Mouse Brain and Has Both Stress-Induced and Homeostatic Functions

International journal of molecular sciences, 2020-07, Vol.21 (14), p.4849

2020

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Enhanced histamine H2 excitation of striatal cholinergic interneurons in l -DOPA-induced dyskinesia

Neurobiology of disease, 2015-04, Vol.76, p.67-76

2015

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Sex-Dependent Liver Gene Expression Is Extensive and Largely Dependent upon Signal Transducer and Activator of Transcription 5b (STAT5b): STAT5b-Dependent Activation of Male Genes and Repression of Female Genes Revealed by Microarray Analysis

Molecular endocrinology (Baltimore, Md.), 2006-06, Vol.20 (6), p.1333-1351

2006

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Pathogenic tau accelerates aging-associated activation of transposable elements in the mouse central nervous system

Progress in neurobiology, 2022-01, Vol.208, p.102181-102181, Article 102181

2022

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LRRTM3 Promotes Processing of Amyloid-Precursor Protein by BACE1 and Is a Positional Candidate Gene for Late-Onset Alzheimer's Disease

Proceedings of the National Academy of Sciences - PNAS, 2006-11, Vol.103 (47), p.17967-17972

2006

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A Regulatory Circuit Mediating Convergence between Nurr1 Transcriptional Regulation and Wnt Signaling

Molecular and Cellular Biology, 2007-11, Vol.27 (21), p.7486-7496

2007

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Identification of Genetic Pathways Activated by the Androgen Receptor during the Induction of Proliferation in the Ventral Prostate Gland

The Journal of biological chemistry, 2004-01, Vol.279 (2), p.1310-1322

2004

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Identification of Anabolic Selective Androgen Receptor Modulators with Reduced Activities in Reproductive Tissues and Sebaceous Glands

The Journal of biological chemistry, 2009-12, Vol.284 (52), p.36367-36376

2009

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A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation

The Journal of experimental medicine, 2023-11, Vol.220 (11)

2023

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Evidence for a Physical Interaction between Presenilin and Notch

Proceedings of the National Academy of Sciences - PNAS, 1999-03, Vol.96 (6), p.3263-3268

1999

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Inhibition of Calcineurin-mediated Endocytosis and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors Prevents Amyloid β Oligomer-induced Synaptic Disruption

The Journal of biological chemistry, 2010-03, Vol.285 (10), p.7619-7632

2010

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Presenilin Complexes with the C-Terminal Fragments of Amyloid Precursor Protein at the Sites of Amyloid β -Protein Generation

Proceedings of the National Academy of Sciences - PNAS, 2000-08, Vol.97 (16), p.9299-9304

2000

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Hybrid Metachronal Rowing Augments Swimming Speed and Acceleration via Increased Stroke Amplitude

Integrative and comparative biology, 2021-11, Vol.61 (5), p.1619-1630

2021

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Androgenic Induction of Growth and Differentiation in the Rodent Uterus Involves the Modulation of Estrogen-Regulated Genetic Pathways

Endocrinology (Philadelphia), 2005-02, Vol.146 (2), p.564-578

2005

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Pathogenic tau-induced transposable element-derived dsRNA drives neuroinflammation

Science advances, 2023-01, Vol.9 (1), p.eabq5423

2023

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High-Throughput Screening by RNA Interference: Control of Two Distinct Types of Variance

Cell cycle (Georgetown, Tex.), 2007-04, Vol.6 (8), p.898-901

2007

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The muscarinic M1 receptor positive allosteric modulator PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque

Psychopharmacology, 2013, Vol.225 (1), p.21-30

2013

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A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

Nature (London), 1999-04, Vol.398 (6727), p.518-522

1999

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From embryonal carcinoma cells to neurons: The P19 pathway

BioEssays, 1994-05, Vol.16 (5), p.343-348

1994

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Discovery of a Selective Allosteric M1 Receptor Modulator with Suitable Development Properties Based on a Quinolizidinone Carboxylic Acid Scaffold

Journal of medicinal chemistry, 2011-07, Vol.54 (13), p.4773-4780

2011

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Identification of an anabolic selective androgen receptor modulator that actively induces death of androgen-independent prostate cancer cells

The Journal of steroid biochemistry and molecular biology, 2014-09, Vol.143, p.29-39

2014

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Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase

Bioorganic & medicinal chemistry letters, 2014-06, Vol.24 (12), p.2737-2740

2014

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Discovery of the Selective Androgen Receptor Modulator MK-0773 Using a Rational Development Strategy Based on Differential Transcriptional Requirements for Androgenic Anabolism Versus Reproductive Physiology

The Journal of biological chemistry, 2010-05, Vol.285 (22), p.17054-17064

2010

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Induction of Alzheimer's-like changes in brain of mice expressing mutant APP fed excess methionine

Journal of neurochemistry, 2011, Vol.116 (1), p.82-92

2011

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Selective activation of the M₁ muscarinic acetylcholine receptor achieved by allosteric potentiation

Dual Leucine Zipper Kinase Is Constitutively Active in the Adult Mouse Brain and Has Both Stress-Induced and Homeostatic Functions

Enhanced histamine H2 excitation of striatal cholinergic interneurons in l -DOPA-induced dyskinesia

Sex-Dependent Liver Gene Expression Is Extensive and Largely Dependent upon Signal Transducer and Activator of Transcription 5b (STAT5b): STAT5b-Dependent Activation of Male Genes and Repression of Female Genes Revealed by Microarray Analysis

Pathogenic tau accelerates aging-associated activation of transposable elements in the mouse central nervous system

LRRTM3 Promotes Processing of Amyloid-Precursor Protein by BACE1 and Is a Positional Candidate Gene for Late-Onset Alzheimer's Disease

A Regulatory Circuit Mediating Convergence between Nurr1 Transcriptional Regulation and Wnt Signaling

Identification of Genetic Pathways Activated by the Androgen Receptor during the Induction of Proliferation in the Ventral Prostate Gland

Identification of Anabolic Selective Androgen Receptor Modulators with Reduced Activities in Reproductive Tissues and Sebaceous Glands

A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation

Evidence for a Physical Interaction between Presenilin and Notch

Inhibition of Calcineurin-mediated Endocytosis and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors Prevents Amyloid β Oligomer-induced Synaptic Disruption

Presenilin Complexes with the C-Terminal Fragments of Amyloid Precursor Protein at the Sites of Amyloid β -Protein Generation

Hybrid Metachronal Rowing Augments Swimming Speed and Acceleration via Increased Stroke Amplitude

Androgenic Induction of Growth and Differentiation in the Rodent Uterus Involves the Modulation of Estrogen-Regulated Genetic Pathways

Pathogenic tau-induced transposable element-derived dsRNA drives neuroinflammation

High-Throughput Screening by RNA Interference: Control of Two Distinct Types of Variance

The muscarinic M1 receptor positive allosteric modulator PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

From embryonal carcinoma cells to neurons: The P19 pathway

Discovery of a Selective Allosteric M1 Receptor Modulator with Suitable Development Properties Based on a Quinolizidinone Carboxylic Acid Scaffold

Identification of an anabolic selective androgen receptor modulator that actively induces death of androgen-independent prostate cancer cells

Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase

Discovery of the Selective Androgen Receptor Modulator MK-0773 Using a Rational Development Strategy Based on Differential Transcriptional Requirements for Androgenic Anabolism Versus Reproductive Physiology

Induction of Alzheimer's-like changes in brain of mice expressing mutant APP fed excess methionine

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