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Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7

Cell, 2019-08, Vol.178 (5), p.1222-1230.e10

2019

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Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody

eLife, 2017-02, Vol.6

2017

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A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence

Nature communications, 2023-12, Vol.14 (1), p.8039-8039, Article 8039

2023

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Stepwise Evolution Improves Identification of Diverse Peptides Binding to a Protein Target

Scientific reports, 2017-09, Vol.7 (1), p.12116-10, Article 12116

2017

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Synthesis, Characterization, and in vivo Evaluation of a Novel Potent Autotaxin-Inhibitor

Frontiers in pharmacology, 2022-01, Vol.12, p.699535-699535

2022

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Chimeric antigen receptor T cells engineered to recognize the P329G-mutated Fc part of effector-silenced tumor antigen-targeting human IgG1 antibodies enable modular targeting of solid tumors

Journal for immunotherapy of cancer, 2022-07, Vol.10 (7), p.e005054

2022

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Unique carbohydrate–carbohydrate interactions are required for high affinity binding between FcγRIII and antibodies lacking core fucose

Proceedings of the National Academy of Sciences - PNAS, 2011-08, Vol.108 (31), p.12669-12674

2011

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Systematic Investigation of Halogen Bonding in Protein-Ligand Interactions

Angewandte Chemie (International ed.), 2011-01, Vol.50 (1), p.314-318

International ed. in English, 2011

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Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β

Journal of Alzheimer's disease, 2012-01, Vol.28 (1), p.49

2012

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Variable heavy-variable light domain and Fab-arm CrossMabs with charged residue exchanges to enforce correct light chain assembly

Protein engineering, design and selection, 2018-07, Vol.31 (7-8), p.289-299

2018

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Structure of the acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1

Nature communications, 2012-07, Vol.3 (1), p.936-936, Article 936

2012

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Novel β‐Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization

Angewandte Chemie International Edition, 2021-03, Vol.60 (10), p.5436-5442

International ed. in English, 2021

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Mapping the conformational space accessible to catechol-O-methyltransferase

Acta crystallographica. Section D, Biological crystallography., 2014-08, Vol.70 (8), p.2163-2174

2014

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Molecular Switch in the Glucocorticoid Receptor: Active and Passive Antagonist Conformations

Journal of molecular biology, 2010-01, Vol.395 (3), p.568-577

2010

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P329G-CAR-J: a novel Jurkat-NFAT-based CAR-T reporter system recognizing the P329G Fc mutation

Protein engineering, design and selection, 2019-12, Vol.32 (5), p.207

2019

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MoFvAb: Modeling the Fv region of antibodies

mAbs, 2015-09, Vol.7 (5), p.838-852

2015

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VH-VL orientation prediction for antibody humanization candidate selection: A case study

mAbs, 2016-01, Vol.8 (2), p.288-305

2016

Volltextzugriff (PDF)

Structure of Gentlyase, the neutral metalloprotease of Paenibacillus polymyxa

Acta crystallographica. Section D, Biological crystallography., 2013-01, Vol.69 (1), p.24-31

2013

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Enhancing the Stability and Solubility of the Glucocorticoid Receptor Ligand-Binding Domain by High-Throughput Library Screening

Journal of molecular biology, 2010-11, Vol.403 (4), p.562-577

2010

Volltextzugriff (PDF)

Determination of Protein–Ligand Binding Constants of a Cooperatively Regulated Tetrameric Enzyme Using Electrospray Mass Spectrometry

ACS chemical biology, 2014-01, Vol.9 (1), p.218-226

2014

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Structure of the Human Fatty Acid Synthase KS–MAT Didomain as a Framework for Inhibitor Design

Journal of molecular biology, 2010-03, Vol.397 (2), p.508-519

2010

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BACE1 inhibitors: A head group scan on a series of amides

Bioorganic & medicinal chemistry letters, 2013-07, Vol.23 (14), p.4239-4243

2013

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Aleglitazar, a new, potent, and balanced dual PPARα/γ agonist for the treatment of type II diabetes

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (9), p.2468-2473

2009

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Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7

Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody

A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence

Stepwise Evolution Improves Identification of Diverse Peptides Binding to a Protein Target

Synthesis, Characterization, and in vivo Evaluation of a Novel Potent Autotaxin-Inhibitor

Chimeric antigen receptor T cells engineered to recognize the P329G-mutated Fc part of effector-silenced tumor antigen-targeting human IgG1 antibodies enable modular targeting of solid tumors

Unique carbohydrate–carbohydrate interactions are required for high affinity binding between FcγRIII and antibodies lacking core fucose

Targeting Tumor-Associated Macrophages with Anti-CSF-1R Antibody Reveals a Strategy for Cancer Therapy

Systematic Investigation of Halogen Bonding in Protein-Ligand Interactions

Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β

Variable heavy-variable light domain and Fab-arm CrossMabs with charged residue exchanges to enforce correct light chain assembly

Structure of the acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1

Novel β‐Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization

CD25-T reg -depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation and antitumor immunity

Mapping the conformational space accessible to catechol-O-methyltransferase

Molecular Switch in the Glucocorticoid Receptor: Active and Passive Antagonist Conformations

P329G-CAR-J: a novel Jurkat-NFAT-based CAR-T reporter system recognizing the P329G Fc mutation

MoFvAb: Modeling the Fv region of antibodies

VH-VL orientation prediction for antibody humanization candidate selection: A case study

Structure of Gentlyase, the neutral metalloprotease of Paenibacillus polymyxa

Enhancing the Stability and Solubility of the Glucocorticoid Receptor Ligand-Binding Domain by High-Throughput Library Screening

Determination of Protein–Ligand Binding Constants of a Cooperatively Regulated Tetrameric Enzyme Using Electrospray Mass Spectrometry

Structure of the Human Fatty Acid Synthase KS–MAT Didomain as a Framework for Inhibitor Design

BACE1 inhibitors: A head group scan on a series of amides

Aleglitazar, a new, potent, and balanced dual PPARα/γ agonist for the treatment of type II diabetes

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