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Design, synthesis, and evaluation of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamides as selective dopamine D3 receptor ligands

Bioorganic & medicinal chemistry letters, 2019-09, Vol.29 (18), p.2690-2694

2019

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Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches

Bioorganic & medicinal chemistry letters, 2003-05, Vol.13 (10), p.1829-1835

2003

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Discovery and structure–activity relationships of 6-(benzoylamino)benzoxaboroles as orally active anti-inflammatory agents

Bioorganic & medicinal chemistry letters, 2013-11, Vol.23 (21), p.5870-5873

2013

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Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus

Bioorganic & medicinal chemistry letters, 2017-05, Vol.27 (9), p.2069-2073

2017

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Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα)

Bioorganic & medicinal chemistry letters, 2020-02, Vol.30 (4), p.126907, Article 126907

2020

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Design, synthesis, and evaluation of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamides as selective dopamine D 3 receptor ligands

Bioorganic & medicinal chemistry letters, 2019-09, Vol.29 (18), p.2690

2019

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Synthesis of 6-hydroxyaurone analogues and evaluation of their α-glucosidase inhibitory and glucose consumption-promoting activity: Development of highly active 5,6-disubstituted derivatives

Bioorganic & medicinal chemistry letters, 2017-08, Vol.27 (15), p.3226-3230

2017

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Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus

Bioorganic & medicinal chemistry letters, 2017-05, Vol.27 (9), p.2063-2068

2017

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Structure-based design and discovery of potent and selective lysine-specific demethylase 1 (LSD1) inhibitors

Bioorganic & medicinal chemistry letters, 2019-01, Vol.29 (1), p.103-106

2019

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Small molecule modulators of Wnt/β-catenin signaling

Bioorganic & medicinal chemistry letters, 2013-04, Vol.23 (7), p.2187-2191

2013

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Identification of novel triazole inhibitors of Wnt/β-catenin signaling based on the Niclosamide chemotype

Bioorganic & medicinal chemistry letters, 2019-01, Vol.29 (2), p.317-321

2019

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Discovery of 2-aminoisobutyric acid ethyl ester (AIBEE) phosphoramidate prodrugs for delivering nucleoside HCV NS5B polymerase inhibitors

Bioorganic & medicinal chemistry letters, 2020-04, Vol.30 (7), p.126986, Article 126986

2020

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Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors

Bioorganic & medicinal chemistry, 2008-06, Vol.18 (11), p.3224-3229

2008

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Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064

Bioorganic & medicinal chemistry, 2008-08, Vol.18 (15), p.4339-4343

2008

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Identification of pyrrolo[2,1- f][1,2,4]triazine-based inhibitors of Met kinase

Bioorganic & medicinal chemistry, 2008-03, Vol.18 (6), p.1945-1951

2008

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Synthesis, iron binding and antimicrobial properties of hexadentate 3-hydroxypyridinones-terminated dendrimers

Bioorganic & medicinal chemistry letters, 2018-08, Vol.28 (14), p.2504-2512

2018

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Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents

Bioorganic & medicinal chemistry letters, 2012-11, Vol.22 (22), p.6832-6838

2012

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Identification of 1-{2-[4-chloro-1′-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4′-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y1 antagonist as an antiplatelet agent

Bioorganic & medicinal chemistry letters, 2014-03, Vol.24 (5), p.1294-1298

2014

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Conformationally constrained farnesoid X receptor (FXR) agonists: Heteroaryl replacements of the naphthalene

Bioorganic & medicinal chemistry letters, 2011-02, Vol.21 (4), p.1206-1213

2011

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Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile

Bioorganic & medicinal chemistry letters, 2012-02, Vol.22 (4), p.1750-1755

2012

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Structure–activity-relationship of amide and sulfonamide analogs of omarigliptin

Bioorganic & medicinal chemistry letters, 2015-12, Vol.25 (24), p.5767-5771

2015

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Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux

Bioorganic & medicinal chemistry letters, 2012-12, Vol.22 (24), p.7371-7375

2012

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Discovery and SAR of new benzazepines as potent and selective 5-HT2C receptor agonists for the treatment of obesity

Bioorganic & medicinal chemistry letters, 2005-03, Vol.15 (5), p.1467-1470

2005

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5-(2-Pyrimidinyl)-imidazo[1,2- a]pyridines are antibacterial agents targeting the ATPase domains of DNA gyrase and topoisomerase IV

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (18), p.5302-5306

2009

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Design, synthesis, and evaluation of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamides as selective dopamine D3 receptor ligands

Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches

Discovery and structure–activity relationships of 6-(benzoylamino)benzoxaboroles as orally active anti-inflammatory agents

Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus

Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer’s disease

Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα)

Design, synthesis, and evaluation of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamides as selective dopamine D 3 receptor ligands

Synthesis of 6-hydroxyaurone analogues and evaluation of their α-glucosidase inhibitory and glucose consumption-promoting activity: Development of highly active 5,6-disubstituted derivatives

Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus

Structure-based design and discovery of potent and selective lysine-specific demethylase 1 (LSD1) inhibitors

Small molecule modulators of Wnt/β-catenin signaling

Identification of novel triazole inhibitors of Wnt/β-catenin signaling based on the Niclosamide chemotype

Discovery of 2-aminoisobutyric acid ethyl ester (AIBEE) phosphoramidate prodrugs for delivering nucleoside HCV NS5B polymerase inhibitors

Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors

Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064

Identification of pyrrolo[2,1- f][1,2,4]triazine-based inhibitors of Met kinase

Synthesis, iron binding and antimicrobial properties of hexadentate 3-hydroxypyridinones-terminated dendrimers

Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents

Identification of 1-{2-[4-chloro-1′-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4′-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y1 antagonist as an antiplatelet agent

Conformationally constrained farnesoid X receptor (FXR) agonists: Heteroaryl replacements of the naphthalene

Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile

Structure–activity-relationship of amide and sulfonamide analogs of omarigliptin

Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux

Discovery and SAR of new benzazepines as potent and selective 5-HT2C receptor agonists for the treatment of obesity

5-(2-Pyrimidinyl)-imidazo[1,2- a]pyridines are antibacterial agents targeting the ATPase domains of DNA gyrase and topoisomerase IV

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