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HCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy

Nature communications, 2023-07, Vol.14 (1), p.4297-4297, Article 4297

2023

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HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib

Blood, 2016-06, Vol.127 (25), p.3237-3252

2016

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The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment

The Journal of experimental medicine, 2014-09, Vol.211 (10), p.1993-2011

2014

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The HCK/BTK inhibitor KIN-8194 is active in MYD88-driven lymphomas and overcomes mutated BTKCys481 ibrutinib resistance

Blood, 2021-11, Vol.138 (20), p.1966-1979

2021

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Src family kinases, HCK and FGR, associate with local inflammation and tumour progression in colorectal cancer

Cellular signalling, 2019-04, Vol.56, p.15-22

2019

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Cocrystallization of the Src-Family Kinase Hck with the ATP-Site Inhibitor A‑419259 Stabilizes an Extended Activation Loop Conformation

Biochemistry (Easton), 2024-10, Vol.63 (20), p.2594-2601

2024

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Early-onset pulmonary and cutaneous vasculitis driven by constitutively active SRC-family kinase HCK

Journal of allergy and clinical immunology, 2022-04, Vol.149 (4), p.1464-1472.e3

2022

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The dual HCK/BTK inhibitor KIN-8194 impairs growth and integrin-mediated adhesion of BTKi-resistant mantle cell lymphoma

Leukemia, 2024-07, Vol.38 (7), p.1570-1580

2024

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Multidomain assembled states of Hck tyrosine kinase in solution

Proceedings of the National Academy of Sciences - PNAS, 2010-09, Vol.107 (36), p.15757-15762

2010

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NEF-Induced HIV-Associated Nephropathy Through HCK/LYN Tyrosine Kinases

The American journal of pathology, 2023-06, Vol.193 (6), p.702-724

2023

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Identification of the SRC-family tyrosine kinase HCK as a therapeutic target in mantle cell lymphoma

Leukemia, 2021-03, Vol.35 (3), p.881-886

2021

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A density-matrix adaptation of the Hckel method to weak covalent networks

Physical chemistry chemical physics : PCCP, 2024-02, Vol.26 (7), p.5879-5894

2024

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Novel Protacs Demonstrate Dual Kinase Inhibition and Degradation of HCK and BTK, and Are Highly Active in MYD88 Mutated WM and ABC DLBCL Cells

Blood, 2023-11, Vol.142 (Supplement 1), p.3298-3298

2023

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Inhibition of HCK in myeloid cells restricts pancreatic tumor growth and metastasis

Cell reports (Cambridge), 2022-10, Vol.41 (2), p.111479-111479, Article 111479

2022

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HIV-1 Nef Induces Hck/Lyn-Dependent Expansion of Myeloid-Derived Suppressor Cells Associated with Elevated Interleukin-17/G-CSF Levels

Journal of virology, 2021-08, Vol.95 (17), p.e0047121-e0047121

2021

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Small-molecule allosteric modulators of the AML-associated Src-family kinase, Hck

Biophysical journal, 2024-02, Vol.123 (3), p.185a-185a

2024

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hCKSAAP_UbSite: Improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties

Biochimica et biophysica acta, 2013-08, Vol.1834 (8), p.1461-1467

2013

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Revealing the Role of the Arg and Lys in Shifting Paradigm from BTK Selective Inhibition to the BTK/HCK Dual Inhibition - Delving into the Inhibitory Activity of KIN-8194 against BTK, and HCK in the Treatment of Mutated BTKCys481 Waldenström Macroglobulinemia: A Computational Approach

Anti-cancer agents in medicinal chemistry, 2024-07, Vol.24 (11), p.813-825

2024

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HCK promotes high-grade serous ovarian cancer tumorigenesis through CD44 and NOTCH3 signaling

Molecular cancer research, 2023-10, Vol.21 (10), p.1037-1049

2023

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Hematopoietic Cell Kinase (HCK) Is a Key Regulator of Macrophage Function in Kidney Fibrosis: FR-PO959

Journal of the American Society of Nephrology, 2022-11, Vol.33 (11S), p.588-589

2022

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Membrane Anchoring of Hck Kinase via the Intrinsically Disordered SH4-U and Length Scale Associated with Subcellular Localization

Journal of molecular biology, 2020-04, Vol.432 (9), p.2985-2997

2020

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Hematopoietic cell kinase (HCK) as a therapeutic target in immune and cancer cells

Oncotarget, 2015-06, Vol.6 (18), p.15752-15771

2015

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Kinase-deficient BTK mutants confer ibrutinib resistance through activation of the kinase HCK

Science signaling, 2022-05, Vol.15 (736), p.eabg5216

2022

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Abstract 1714: Small Molecule Allosteric Modulators of the AML-associated Src-family Kinase, Hck

The Journal of biological chemistry, 2023, Vol.299 (3), p.103253, Article 103253

2023

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Selective targeting of the inactive state of hematopoietic cell kinase (Hck) with a stable curcumin derivative

The Journal of biological chemistry, 2021-01, Vol.296, p.100449-100449, Article 100449

2021

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HCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy

HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib

The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment

The HCK/BTK inhibitor KIN-8194 is active in MYD88-driven lymphomas and overcomes mutated BTKCys481 ibrutinib resistance

Src family kinases, HCK and FGR, associate with local inflammation and tumour progression in colorectal cancer

Cocrystallization of the Src-Family Kinase Hck with the ATP-Site Inhibitor A‑419259 Stabilizes an Extended Activation Loop Conformation

Early-onset pulmonary and cutaneous vasculitis driven by constitutively active SRC-family kinase HCK

The dual HCK/BTK inhibitor KIN-8194 impairs growth and integrin-mediated adhesion of BTKi-resistant mantle cell lymphoma

Multidomain assembled states of Hck tyrosine kinase in solution

NEF-Induced HIV-Associated Nephropathy Through HCK/LYN Tyrosine Kinases

Identification of the SRC-family tyrosine kinase HCK as a therapeutic target in mantle cell lymphoma

A density-matrix adaptation of the Hckel method to weak covalent networks

Novel Protacs Demonstrate Dual Kinase Inhibition and Degradation of HCK and BTK, and Are Highly Active in MYD88 Mutated WM and ABC DLBCL Cells

Inhibition of HCK in myeloid cells restricts pancreatic tumor growth and metastasis

HIV-1 Nef Induces Hck/Lyn-Dependent Expansion of Myeloid-Derived Suppressor Cells Associated with Elevated Interleukin-17/G-CSF Levels

Small-molecule allosteric modulators of the AML-associated Src-family kinase, Hck

hCKSAAP_UbSite: Improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties

Revealing the Role of the Arg and Lys in Shifting Paradigm from BTK Selective Inhibition to the BTK/HCK Dual Inhibition - Delving into the Inhibitory Activity of KIN-8194 against BTK, and HCK in the Treatment of Mutated BTKCys481 Waldenström Macroglobulinemia: A Computational Approach

HCK promotes high-grade serous ovarian cancer tumorigenesis through CD44 and NOTCH3 signaling

Hematopoietic Cell Kinase (HCK) Is a Key Regulator of Macrophage Function in Kidney Fibrosis: FR-PO959

Membrane Anchoring of Hck Kinase via the Intrinsically Disordered SH4-U and Length Scale Associated with Subcellular Localization

Hematopoietic cell kinase (HCK) as a therapeutic target in immune and cancer cells

Kinase-deficient BTK mutants confer ibrutinib resistance through activation of the kinase HCK

Abstract 1714: Small Molecule Allosteric Modulators of the AML-associated Src-family Kinase, Hck

Selective targeting of the inactive state of hematopoietic cell kinase (Hck) with a stable curcumin derivative

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