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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

Nature (London), 2010-03, Vol.464 (7287), p.431-435

2010

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Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy

Cells (Basel, Switzerland), 2020-01, Vol.9 (1), p.198

2020

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Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers

Cell, 2013-08, Vol.154 (5), p.1036-1046

2013

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Targeting Alterations in the RAF-MEK Pathway

Cancer discovery, 2019-03, Vol.9 (3), p.329-341

2019

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Arabidopsis Raf‐like kinases act as positive regulators of subclass III SnRK2 in osmostress signaling

The Plant journal : for cell and molecular biology, 2020-07, Vol.103 (2), p.634-644

2020

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Regulation of RAF protein kinases in ERK signalling

Nature reviews. Molecular cell biology, 2015-05, Vol.16 (5), p.281-298

2015

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Structural basis for the action of the drug trametinib at KSR-bound MEK

Nature (London), 2020-12, Vol.588 (7838), p.509-514

2020

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A RAF-SnRK2 kinase cascade mediates early osmotic stress signaling in higher plants

Nature communications, 2020-01, Vol.11 (1), p.613-613, Article 613

2020

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Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling

Molecular cell, 2019-12, Vol.76 (6), p.872-884.e5

2019

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Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response

Oncotarget, 2012-09, Vol.3 (9), p.954-987

2012

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Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant Tumors

Cancer cell, 2014-05, Vol.25 (5), p.697-710

2014

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PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents: Structural and pharmacological perspectives

European journal of medicinal chemistry, 2016-02, Vol.109, p.314-341

2016

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A lactate-induced response to hypoxia

Cell, 2015-04, Vol.161 (3), p.595-609

2015

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Targeting the MAPK-RAS-RAF signaling pathway in cancer therapy

Expert opinion on therapeutic targets, 2012-01, Vol.16 (1), p.103-119

2012

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Cancer resistance to therapies against the EGFR-RAS-RAF pathway: the role of MEK

Cancer treatment reviews, 2017-02, Vol.53, p.61-69

2017

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Plant Raf-like kinase integrates abscisic acid and hyperosmotic stress signaling upstream of SNF1-related protein kinase2

Proceedings of the National Academy of Sciences - PNAS, 2015-11, Vol.112 (46), p.E6388-E6396

2015

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MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors

The Journal of clinical investigation, 2013-01, Vol.123 (1), p.340-347

2013

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Raf promotes dimerization of the Ras G-domain with increased allosteric connections

Proceedings of the National Academy of Sciences - PNAS, 2021-03, Vol.118 (10), p.1-11

2021

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Inhibition of RAF dimers: it takes two to tango

Biochemical Society transactions, 2021-02, Vol.49 (1), p.237-251

2021

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Consensus on the RAS dimerization hypothesis: Strong evidence for lipid-mediated clustering but not for G-domain-mediated interactions

Molecular cell, 2023-04, Vol.83 (8), p.1210-1215

2023

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Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3

The Journal of clinical investigation, 2013-05, Vol.123 (5), p.2155-2168

2013

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Current Development Status of MEK Inhibitors

Molecules (Basel, Switzerland), 2017-09, Vol.22 (10), p.1551

2017

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Allele-Specific Mechanisms of Activation of MEK1 Mutants Determine Their Properties

Cancer discovery, 2018-05, Vol.8 (5), p.648-661

2018

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Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations

Molecular cancer research, 2015-09, Vol.13 (9), p.1325-1335

2015

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Stochastic ERK activation induced by noise and cell-to-cell propagation regulates cell density-dependent proliferation

Molecular cell, 2013-11, Vol.52 (4), p.529-540

2013

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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy

Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers

Targeting Alterations in the RAF-MEK Pathway

Arabidopsis Raf‐like kinases act as positive regulators of subclass III SnRK2 in osmostress signaling

Regulation of RAF protein kinases in ERK signalling

Structural basis for the action of the drug trametinib at KSR-bound MEK

A RAF-SnRK2 kinase cascade mediates early osmotic stress signaling in higher plants

Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling

Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response

Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant Tumors

PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents: Structural and pharmacological perspectives

A lactate-induced response to hypoxia

Targeting the MAPK-RAS-RAF signaling pathway in cancer therapy

Cancer resistance to therapies against the EGFR-RAS-RAF pathway: the role of MEK

Plant Raf-like kinase integrates abscisic acid and hyperosmotic stress signaling upstream of SNF1-related protein kinase2

MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors

Raf promotes dimerization of the Ras G-domain with increased allosteric connections

Inhibition of RAF dimers: it takes two to tango

Consensus on the RAS dimerization hypothesis: Strong evidence for lipid-mediated clustering but not for G-domain-mediated interactions

Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3

Current Development Status of MEK Inhibitors

Allele-Specific Mechanisms of Activation of MEK1 Mutants Determine Their Properties

Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations

Stochastic ERK activation induced by noise and cell-to-cell propagation regulates cell density-dependent proliferation

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