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Stability effects of mutations and protein evolvability

Current opinion in structural biology, 2009-10, Vol.19 (5), p.596-604

2009

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Mutational effects and the evolution of new protein functions

Nature reviews. Genetics, 2010-08, Vol.11 (8), p.572

2010

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Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability

Molecular cell, 2016-07, Vol.63 (2), p.337-346

2016

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Identification of the algal dimethyl sulfide–releasing enzyme: A missing link in the marine sulfur cycle

Science (American Association for the Advancement of Science), 2015-06, Vol.348 (6242), p.1466-1469

2015

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De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints

Cell, 2016-01, Vol.164 (3), p.476-486

2016

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On the Potential Origins of the High Stability of Reconstructed Ancestral Proteins

Molecular biology and evolution, 2016-10, Vol.33 (10), p.2633-2641

2016

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Bridging Themes: Short Protein Segments Found in Different Architectures

Molecular biology and evolution, 2021-05, Vol.38 (6), p.2191-2208

2021

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A Bird’s-Eye View of Enzyme Evolution: Chemical, Physicochemical, and Physiological Considerations

Chemical reviews, 2018-09, Vol.118 (18), p.8786-8797

2018

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Determining the interaction status and evolutionary fate of duplicated homomeric proteins

PLoS computational biology, 2020-08, Vol.16 (8), p.e1008145-e1008145

2020

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Automated Design of Efficient and Functionally Diverse Enzyme Repertoires

Molecular cell, 2018-10, Vol.72 (1), p.178-186.e5

2018

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An Ancient Fingerprint Indicates the Common Ancestry of Rossmann-Fold Enzymes Utilizing Different Ribose-Based Cofactors

PLoS biology, 2016-03, Vol.14 (3), p.e1002396-e1002396

2016

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Rescue of conformational dynamics in enzyme catalysis by directed evolution

Nature communications, 2018-04, Vol.9 (1), p.1314-11, Article 1314

2018

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Evolution of chalcone isomerase from a noncatalytic ancestor

Nature chemical biology, 2018-06, Vol.14 (6), p.548

2018

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Systematic Mapping of Protein Mutational Space by Prolonged Drift Reveals the Deleterious Effects of Seemingly Neutral Mutations

PLoS computational biology, 2015-08, Vol.11 (8), p.e1004421

2015

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Noise-mean relationship in mutated promoters

Genome research, 2012-12, Vol.22 (12), p.2409

2012

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Short and simple sequences favored the emergence of N-helix phospho-ligand binding sites in the first enzymes

Proceedings of the National Academy of Sciences - PNAS, 2020-03, Vol.117 (10), p.5310-5318

2020

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Primordial emergence of a nucleic acid-binding protein via phase separation and statistical ornithine-to-arginine conversion

Proceedings of the National Academy of Sciences - PNAS, 2020-07, Vol.117 (27), p.15731-15739

2020

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Diminishing returns and tradeoffs constrain the laboratory optimization of an enzyme

Nature communications, 2012, Vol.3 (1), p.1257, Article 1257

2012

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Functional Proteins from Short Peptides: Dayhoff's Hypothesis Turns 50

Angewandte Chemie (International ed.), 2016-12, Vol.55 (52), p.15966-15971

International ed. in English, 2016

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Initial mutations direct alternative pathways of protein evolution

PLoS genetics, 2011-03, Vol.7 (3), p.e1001321

2011

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Helicase-like functions in phosphate loop containing beta-alpha polypeptides

Proceedings of the National Academy of Sciences - PNAS, 2021-04, Vol.118 (16), p.1

2021

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Simple yet functional phosphate-loop proteins

Proceedings of the National Academy of Sciences - PNAS, 2018-12, Vol.115 (51), p.E11943-E11950

2018

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The molecular basis of phosphate discrimination in arsenate―rich environments

Nature (London), 2012-11, Vol.491 (7422), p.134-137

2012

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On the emergence of P-Loop NTPase and Rossmann enzymes from a Beta-Alpha-Beta ancestral fragment

eLife, 2020-12, Vol.9

2020

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Methanol-free biosynthesis of fatty acid methyl ester (FAME) in Synechocystis sp. PCC 6803

Metabolic engineering, 2020-01, Vol.57, p.217-227

2020

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Stability effects of mutations and protein evolvability

Mutational effects and the evolution of new protein functions

Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability

Identification of the algal dimethyl sulfide–releasing enzyme: A missing link in the marine sulfur cycle

De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints

On the Potential Origins of the High Stability of Reconstructed Ancestral Proteins

Bridging Themes: Short Protein Segments Found in Different Architectures

A Bird’s-Eye View of Enzyme Evolution: Chemical, Physicochemical, and Physiological Considerations

Determining the interaction status and evolutionary fate of duplicated homomeric proteins

Automated Design of Efficient and Functionally Diverse Enzyme Repertoires

An Ancient Fingerprint Indicates the Common Ancestry of Rossmann-Fold Enzymes Utilizing Different Ribose-Based Cofactors

Rescue of conformational dynamics in enzyme catalysis by directed evolution

Evolution of chalcone isomerase from a noncatalytic ancestor

Systematic Mapping of Protein Mutational Space by Prolonged Drift Reveals the Deleterious Effects of Seemingly Neutral Mutations

Noise-mean relationship in mutated promoters

Short and simple sequences favored the emergence of N-helix phospho-ligand binding sites in the first enzymes

Primordial emergence of a nucleic acid-binding protein via phase separation and statistical ornithine-to-arginine conversion

Diminishing returns and tradeoffs constrain the laboratory optimization of an enzyme

Functional Proteins from Short Peptides: Dayhoff's Hypothesis Turns 50

Initial mutations direct alternative pathways of protein evolution

Helicase-like functions in phosphate loop containing beta-alpha polypeptides

Simple yet functional phosphate-loop proteins

The molecular basis of phosphate discrimination in arsenate―rich environments

On the emergence of P-Loop NTPase and Rossmann enzymes from a Beta-Alpha-Beta ancestral fragment

Methanol-free biosynthesis of fatty acid methyl ester (FAME) in Synechocystis sp. PCC 6803

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