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Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes

Proceedings of the National Academy of Sciences - PNAS, 2010-08, Vol.107 (34), p.15240-15245

2010

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Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

Nature structural & molecular biology, 2004-12, Vol.11 (12), p.1192-1197

2004

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Characterization of substrate binding and catalysis in the potential antibacterial target N‐acetylglucosamine‐1‐phosphate uridyltransferase (GlmU)

Protein science, 2007-12, Vol.16 (12), p.2657-2666

2007

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Discovery of a Series of Imidazo[4,5-b]pyridines with Dual Activity at Angiotensin II Type 1 Receptor and Peroxisome Proliferator-Activated Receptor-γ

Journal of medicinal chemistry, 2011-06, Vol.54 (12), p.4219-4233

2011

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Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (3), p.767-772

2013

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The structure of a redundant enzyme: a second isoform of aspartate β-semialdehyde dehydrogenase in Vibrio cholerae

Acta crystallographica. Section D, Biological crystallography., 2008-03, Vol.64 (3), p.321-330

2008

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A New Branch in the Family: Structure of Aspartate-β-semialdehyde Dehydrogenase from Methanococcus jannaschii

Journal of molecular biology, 2005-11, Vol.353 (5), p.1055-1068

2005

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4-Anilino-5-carboxamido-2-pyridone Derivatives as Noncompetitive Inhibitors of Mitogen-Activated Protein Kinase Kinase

Journal of medicinal chemistry, 2007-10, Vol.50 (21), p.5090-5102

2007

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Synthesis and evaluation of novel α-heteroaryl-phenylpropanoic acid derivatives as PPARα/γ dual agonists

Bioorganic & medicinal chemistry, 2009-10, Vol.17 (20), p.7113-7125

2009

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Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARα/γ dual agonists, and X-ray crystallographic studies

Bioorganic & medicinal chemistry, 2008-05, Vol.16 (9), p.4883-4907

2008

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The mitogen-activated protein kinase pathway for molecular-targeted cancer treatment

Recent results in cancer research, 2007, Vol.172, p.155

2007

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Inhibitors of Bcr-abl... breaking new ground again

Nature chemical biology, 2006-02, Vol.2 (2), p.63-64

2006

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Structural asymmetry and intersubunit communication in muscle creatine kinase

Acta crystallographica. Section D, Biological crystallography., 2007-03, Vol.63 (3), p.381-389

2007

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A New Branch in the Family: Structure of Aspartate-[beta]-semialdehyde Dehydrogenase from Methanococcus jannaschii

Journal of molecular biology, 2010-07, Vol.353 ((5) ; 2005)

2010

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Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-[gamma]

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (3), p.767-772

2013

Volltextzugriff (PDF)

Discovery of a Series of Imidazo[4,5-b]pyridines with Dual Activity at Angiotensin II Type 1 Receptor and Peroxisome Proliferator-Activated Receptor-[gamma]

Journal of medicinal chemistry, 2013-03, Vol.54 ((12) ; 06, 2011)

2013

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Synthesis and evaluation of novel [alpha]-heteroaryl-phenylpropanoic acid derivatives as PPAR[alpha/gamma] dual agonists

Bioorganic & medicinal chemistry letters, 2010-09, Vol.17 ((20) ; 10, 2009)

2010

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Dynamic light-scattering analysis of full-length human RPA14/32 dimer: purification, crystallization and self-association

Acta crystallographica. Section D, Biological crystallography., 2001-02, Vol.57 (2), p.254-259

2001

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Central Modulation of Circadian Rhythm via CK1 Inhibition for Psychiatric Indications

Annual Reports in Medicinal Chemistry, 2011, Vol.46, p.33-51

2011

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Structural and functional studies of aspartate β-semialdehyde dehydrogenase, aspartokinase and creatine kinase

Ohren, Jeffrey F

2007

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Erratum: Corrigendum: Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

Nature structural & molecular biology, 2005-03, Vol.12 (3), p.278-278

2005

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Corrigendum: Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

Nature structural & molecular biology, 2005-03, Vol.12 (3), p.278-278

2005

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Synthesis and evaluation of novel alpha-heteroaryl-phenylpropanoic acid derivatives as PPARalpha/gamma dual agonists

Bioorganic & medicinal chemistry, 2009-10, Vol.17 (20), p.7113-7125

2009

Volltextzugriff (PDF)

Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARalpha/gamma dual agonists, and X-ray crystallographic studies

Bioorganic & medicinal chemistry, 2008-05, Vol.16 (9), p.4883-4907

2008

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Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

Characterization of substrate binding and catalysis in the potential antibacterial target N‐acetylglucosamine‐1‐phosphate uridyltransferase (GlmU)

Discovery of a Series of Imidazo[4,5-b]pyridines with Dual Activity at Angiotensin II Type 1 Receptor and Peroxisome Proliferator-Activated Receptor-γ

Aminopyrazole Carboxamide Bruton’s Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning

Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ

The structure of a redundant enzyme: a second isoform of aspartate β-semialdehyde dehydrogenase in Vibrio cholerae

A New Branch in the Family: Structure of Aspartate-β-semialdehyde Dehydrogenase from Methanococcus jannaschii

4-Anilino-5-carboxamido-2-pyridone Derivatives as Noncompetitive Inhibitors of Mitogen-Activated Protein Kinase Kinase

Synthesis and evaluation of novel α-heteroaryl-phenylpropanoic acid derivatives as PPARα/γ dual agonists

Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARα/γ dual agonists, and X-ray crystallographic studies

The mitogen-activated protein kinase pathway for molecular-targeted cancer treatment

Inhibitors of Bcr-abl... breaking new ground again

Structural asymmetry and intersubunit communication in muscle creatine kinase

A New Branch in the Family: Structure of Aspartate-[beta]-semialdehyde Dehydrogenase from Methanococcus jannaschii

Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-[gamma]

Discovery of a Series of Imidazo[4,5-b]pyridines with Dual Activity at Angiotensin II Type 1 Receptor and Peroxisome Proliferator-Activated Receptor-[gamma]

Synthesis and evaluation of novel [alpha]-heteroaryl-phenylpropanoic acid derivatives as PPAR[alpha/gamma] dual agonists

Dynamic light-scattering analysis of full-length human RPA14/32 dimer: purification, crystallization and self-association

Central Modulation of Circadian Rhythm via CK1 Inhibition for Psychiatric Indications

Structural and functional studies of aspartate β-semialdehyde dehydrogenase, aspartokinase and creatine kinase

Erratum: Corrigendum: Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

Corrigendum: Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

Synthesis and evaluation of novel alpha-heteroaryl-phenylpropanoic acid derivatives as PPARalpha/gamma dual agonists

Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARalpha/gamma dual agonists, and X-ray crystallographic studies

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