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The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2Hi Macrophages in Breast Cancer and Pancreatic Neuroendocrine Tumors

Molecular cancer therapeutics, 2017-11, Vol.16 (11), p.2486-2501

2017

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A Phase I Study of LY3009120, a Pan-RAF Inhibitor, in Patients with Advanced or Metastatic Cancer

Molecular cancer therapeutics, 2020-02, Vol.19 (2), p.460-467

2020

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Evolution of a Gram-Scale Synthesis of (+)-Discodermolide

Journal of the American Chemical Society, 2000-09, Vol.122 (36), p.8654-8664

2000

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Vimseltinib: A Precision CSF1R Therapy for Tenosynovial Giant Cell Tumors and Diseases Promoted by Macrophages

Molecular cancer therapeutics, 2021-11, Vol.20 (11), p.2098-2109

2021

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Discovery of vimseltinib (DCC-3014), a highly selective CSF1R switch-control kinase inhibitor, in clinical development for the treatment of Tenosynovial Giant Cell Tumor (TGCT)

Bioorganic & medicinal chemistry letters, 2022-10, Vol.74, p.128928-128928, Article 128928

2022

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Discovery of acyl ureas as highly selective small molecule CSF1R kinase inhibitors

Bioorganic & medicinal chemistry letters, 2022-10, Vol.74, p.128929-128929, Article 128929

2022

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Discovery of 1‑(3,3-Dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3‑d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a Pan-RAF Inhibitor with Minimal Paradoxical Activation and Activity against BRAF or RAS Mutant Tumor Cells

Journal of medicinal chemistry, 2015-05, Vol.58 (10), p.4165-4179

2015

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Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2

Molecular cancer therapeutics, 2015-09, Vol.14 (9), p.2023-2034

2015

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Abstract 4889: The highly specific CSF1R inhibitor DCC-3014 exhibits immunomodulatory and anti-invasive activities in cancer models

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.4889-4889

2016

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Update on Best Practice Recommendations for Anesthetic Perioperative Care and Pain Management in Weight Loss Surgery, 2004-2007

Obesity (Silver Spring, Md.), 2009-05, Vol.17 (5), p.889-894

2009

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Course of relapsing–remitting multiple sclerosis before, during and after natalizumab

Multiple sclerosis, 2011-04, Vol.17 (4), p.490-494

2011

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Double-lumen tubes: which lumen for the gum elastic bougie?

Anesthesia and analgesia, 2010-01, Vol.110 (1), p.258; author reply 258-258; author reply 259

2010

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Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (4), p.1046-1050

2013

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Taxol and Discodermolide Represent a Synergistic Drug Combination in Human Carcinoma Cell Lines

Clinical cancer research, 2000-05, Vol.6 (5), p.1978

2000

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Switch control pocket inhibitors of p38-MAP kinase. Durable type II inhibitors that do not require binding into the canonical ATP hinge region

Bioorganic & medicinal chemistry letters, 2010-10, Vol.20 (19), p.5793-5798

2010

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Gram-Scale Synthesis of (+)-Discodermolide

Organic letters, 1999-12, Vol.1 (11), p.1823-1826

1999

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4-Anilino-5-carboxamido-2-pyridone Derivatives as Noncompetitive Inhibitors of Mitogen-Activated Protein Kinase Kinase

Journal of medicinal chemistry, 2007-10, Vol.50 (21), p.5090-5102

2007

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Multiple sclerosis: severity and progression rate in African Americans compared with whites

American journal of physical medicine & rehabilitation, 2003-08, Vol.82 (8), p.582-590

2003

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Effective inhibition of c-MET-mediated signaling, growth and migration of ovarian cancer cells is influenced by the ovarian tissue microenvironment

Oncogene, 2015-01, Vol.34 (2), p.144-153

2015

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Intramolecular Imino Diels−Alder Reaction of a 3-Vinyl Indole: Application to a Total Synthesis of (±)-Eburnamonine

Journal of organic chemistry, 1999-10, Vol.64 (20), p.7586-7593

1999

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Sustained-release oral fampridine in multiple sclerosis: a randomised, double-blind, controlled trial

The Lancet (British edition), 2009-02, Vol.373 (9665), p.732-738

2009

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Construction of Carbocyclic Arrays Containing Nitrogen via Intramolecular Imino Diels−Alder Reactions in Polar Media. A Comparative Study: 5.0 M Lithium Perchlorate−Diethyl Ether versus Water

Journal of organic chemistry, 1999-08, Vol.64 (16), p.6041-6048

1999

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Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants

Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers

The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2Hi Macrophages in Breast Cancer and Pancreatic Neuroendocrine Tumors

A Phase I Study of LY3009120, a Pan-RAF Inhibitor, in Patients with Advanced or Metastatic Cancer

Evolution of a Gram-Scale Synthesis of (+)-Discodermolide

Vimseltinib: A Precision CSF1R Therapy for Tenosynovial Giant Cell Tumors and Diseases Promoted by Macrophages

Discovery of vimseltinib (DCC-3014), a highly selective CSF1R switch-control kinase inhibitor, in clinical development for the treatment of Tenosynovial Giant Cell Tumor (TGCT)

Conformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036

Discovery of acyl ureas as highly selective small molecule CSF1R kinase inhibitors

Discovery of 1‑(3,3-Dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3‑d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a Pan-RAF Inhibitor with Minimal Paradoxical Activation and Activity against BRAF or RAS Mutant Tumor Cells

Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2

Abstract 4889: The highly specific CSF1R inhibitor DCC-3014 exhibits immunomodulatory and anti-invasive activities in cancer models

Update on Best Practice Recommendations for Anesthetic Perioperative Care and Pain Management in Weight Loss Surgery, 2004-2007

Course of relapsing–remitting multiple sclerosis before, during and after natalizumab

Double-lumen tubes: which lumen for the gum elastic bougie?

Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase

Taxol and Discodermolide Represent a Synergistic Drug Combination in Human Carcinoma Cell Lines

Switch control pocket inhibitors of p38-MAP kinase. Durable type II inhibitors that do not require binding into the canonical ATP hinge region

Gram-Scale Synthesis of (+)-Discodermolide

4-Anilino-5-carboxamido-2-pyridone Derivatives as Noncompetitive Inhibitors of Mitogen-Activated Protein Kinase Kinase

Multiple sclerosis: severity and progression rate in African Americans compared with whites

Effective inhibition of c-MET-mediated signaling, growth and migration of ovarian cancer cells is influenced by the ovarian tissue microenvironment

Intramolecular Imino Diels−Alder Reaction of a 3-Vinyl Indole: Application to a Total Synthesis of (±)-Eburnamonine

Sustained-release oral fampridine in multiple sclerosis: a randomised, double-blind, controlled trial

Construction of Carbocyclic Arrays Containing Nitrogen via Intramolecular Imino Diels−Alder Reactions in Polar Media. A Comparative Study: 5.0 M Lithium Perchlorate−Diethyl Ether versus Water

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