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Novel molecular hybrids of cinnamic acids and guanylhydrazones as potential antitubercular agents

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (5), p.1623-1625

2010

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Design, synthesis, and biological evaluation of 4-(5-nitrofuran-2-yl)prop-2-en-1-one derivatives as potent antitubercular agents

Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (21), p.6175-6178

2010

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Aromatic amide derivatives of 5,6-dimethoxy-2,3-dihydro-1H -inden ( -1 -yl )acetic acid as anti-inflammatory agents free of ulcerogenic liability

Bioorganic & medicinal chemistry letters, 2007-12, Vol.17 (24), p.6790-6796

2007

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Versatile synthesis of new cytotoxic agents structurally related to hemiasterlins

Bioorganic & medicinal chemistry letters, 2010-06, Vol.20 (11), p.3431-3435

2010

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The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase

Bioorganic & medicinal chemistry, 2008-08, Vol.18 (15), p.4373-4376

2008

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HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules

Bioorganic & medicinal chemistry letters, 2019-05, Vol.29 (9), p.1106-1112

2019

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Structure–activity relationship study of beta-carboline derivatives as haspin kinase inhibitors

Bioorganic & medicinal chemistry letters, 2012-03, Vol.22 (5), p.2015-2019

2012

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Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections

Bioorganic & medicinal chemistry letters, 2019-07, Vol.29 (13), p.1665-1672

2019

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Identification of a novel class of quinoline–oxadiazole hybrids as anti-tuberculosis agents

Bioorganic & medicinal chemistry letters, 2016-01, Vol.26 (2), p.645-649

2016

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Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors

Bioorganic & medicinal chemistry letters, 2018-02, Vol.28 (4), p.577-583

2018

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Design, synthesis and antimycobacterial activity of cinnamide derivatives: A molecular hybridization approach

Bioorganic & medicinal chemistry letters, 2011-04, Vol.21 (7), p.1997-1999

2011

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Quinazolinethiones and quinazolinediones, novel inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure–activity relationships

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (3), p.751-754

2005

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Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution

Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (22), p.6483-6488

2010

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Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase

Bioorganic & medicinal chemistry letters, 2014-06, Vol.24 (12), p.2737-2740

2014

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Novel 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones as IMPDH inhibitors

Bioorganic & medicinal chemistry letters, 2005-12, Vol.15 (23), p.5335-5339

2005

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Rational drug design based synthesis of novel arylquinolines as anti-tuberculosis agents

Bioorganic & medicinal chemistry letters, 2013-11, Vol.23 (22), p.6097-6105

2013

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Synthesis and preliminary biological evaluation of novel N-(3-aryl-1,2,4-triazol-5-yl) cinnamamide derivatives as potential antimycobacterial agents: An operational Topliss Tree approach

Bioorganic & medicinal chemistry letters, 2011-11, Vol.21 (21), p.6523-6526

2011

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Approaches towards the development of chimeric DPP4/ACE inhibitors for treating metabolic syndrome

Bioorganic & medicinal chemistry letters, 2017-06, Vol.27 (11), p.2313-2318

2017

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Structure-guided design of α-amino acid-derived Pin1 inhibitors

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (2), p.586-590

2010

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Preparation of novel aza-1,7-annulated indoles and their conversion to potent indolocarbazole kinase inhibitors

Bioorganic & medicinal chemistry letters, 2004-08, Vol.14 (15), p.3925-3928

2004

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A novel class of 3-(phenoxy-phenyl-methyl)-pyrrolidines as potent and balanced norepinephrine and serotonin reuptake inhibitors: Synthesis and structure–activity relationships

Bioorganic & medicinal chemistry letters, 2013-03, Vol.23 (5), p.1456-1461

2013

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Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M 1 positive allosteric modulators

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (2), p.531-536

2010

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Quinolizidinone carboxylic acid selective M1 allosteric modulators: SAR in the piperidine series

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (6), p.1710-1715

2011

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1,7-Annulated indolocarbazoles as cyclin-dependent kinase inhibitors

Bioorganic & medicinal chemistry letters, 2004-06, Vol.14 (12), p.3217-3220

2004

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Discovery and optimization of novel, non-steroidal glucocorticoid receptor modulators

Bioorganic & medicinal chemistry letters, 2007-09, Vol.17 (17), p.4901-4905

2007

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Novel molecular hybrids of cinnamic acids and guanylhydrazones as potential antitubercular agents

Design, synthesis, and biological evaluation of 4-(5-nitrofuran-2-yl)prop-2-en-1-one derivatives as potent antitubercular agents

Aromatic amide derivatives of 5,6-dimethoxy-2,3-dihydro-1H -inden ( -1 -yl )acetic acid as anti-inflammatory agents free of ulcerogenic liability

Versatile synthesis of new cytotoxic agents structurally related to hemiasterlins

The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase

HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules

Structure–activity relationship study of beta-carboline derivatives as haspin kinase inhibitors

Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections

Identification of a novel class of quinoline–oxadiazole hybrids as anti-tuberculosis agents

Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors

Design, synthesis and antimycobacterial activity of cinnamide derivatives: A molecular hybridization approach

Quinazolinethiones and quinazolinediones, novel inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure–activity relationships

Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution

Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase

Novel 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones as IMPDH inhibitors

Rational drug design based synthesis of novel arylquinolines as anti-tuberculosis agents

Synthesis and preliminary biological evaluation of novel N-(3-aryl-1,2,4-triazol-5-yl) cinnamamide derivatives as potential antimycobacterial agents: An operational Topliss Tree approach

Approaches towards the development of chimeric DPP4/ACE inhibitors for treating metabolic syndrome

Structure-guided design of α-amino acid-derived Pin1 inhibitors

Preparation of novel aza-1,7-annulated indoles and their conversion to potent indolocarbazole kinase inhibitors

A novel class of 3-(phenoxy-phenyl-methyl)-pyrrolidines as potent and balanced norepinephrine and serotonin reuptake inhibitors: Synthesis and structure–activity relationships

Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M 1 positive allosteric modulators

Quinolizidinone carboxylic acid selective M1 allosteric modulators: SAR in the piperidine series

1,7-Annulated indolocarbazoles as cyclin-dependent kinase inhibitors

Discovery and optimization of novel, non-steroidal glucocorticoid receptor modulators

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