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The Importance of Patient-Specific Factors for Hepatic Drug Response and Toxicity

International journal of molecular sciences, 2016-10, Vol.17 (10), p.1714-1714

2016

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Genetic variation in the human cytochrome P450 supergene family

Pharmacogenetics and genomics, 2015-12, Vol.25 (12), p.584-594

2015

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Novel genetic and epigenetic factors of importance for inter-individual differences in drug disposition, response and toxicity

Pharmacology & therapeutics (Oxford), 2019-05, Vol.197, p.122-152

2019

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3D human liver spheroids for translational pharmacology and toxicology

Basic & clinical pharmacology & toxicology, 2022-01, Vol.130 (S1), p.5-15

2022

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Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions

Toxicological sciences, 2018-06, Vol.163 (2), p.655-665

2018

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Towards more accurate pharmacogenomic variant effect predictions

Pharmacogenomics, 2023-11, Vol.24 (16), p.841-844

2023

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Human hepatic 3D spheroids as a model for steatosis and insulin resistance

Scientific reports, 2018-09, Vol.8 (1), p.14297-12, Article 14297

2018

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Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation

Cell, 2018-02, Vol.172 (5), p.1079-1090.e12

2018

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Scaling of embryonic patterning based on phase―gradient encoding

Nature (London), 2013-01, Vol.493 (7430), p.101-105

2013

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Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long‐term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics

The FASEB journal, 2017-06, Vol.31 (6), p.2696-2708

2017

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In vitro and ex vivo models of adipocytes

American Journal of Physiology: Cell Physiology, 2021-05, Vol.320 (5), p.C822-C841

2021

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How to Consider Rare Genetic Variants in Personalized Drug Therapy

Clinical pharmacology and therapeutics, 2018-05, Vol.103 (5), p.745-748

2018

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Human soluble ACE2 improves the effect of remdesivir in SARS‐CoV‐2 infection

EMBO molecular medicine, 2021-01, Vol.13 (1), p.e13426-n/a

2021

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Can CYP Inhibition Overcome Chemotherapy Resistance?

Trends in pharmacological sciences (Regular ed.), 2020-08, Vol.41 (8), p.503-506

2020

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Development of the PGx‐Passport: A Panel of Actionable Germline Genetic Variants for Pre‐Emptive Pharmacogenetic Testing

Clinical pharmacology and therapeutics, 2019-10, Vol.106 (4), p.866-873

2019

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Comprehensive overview of the pharmacogenetic diversity in Ashkenazi Jews

Journal of medical genetics, 2018-09, Vol.55 (9), p.617-627

2018

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Comprehensive Evaluation of Organotypic and Microphysiological Liver Models for Prediction of Drug-Induced Liver Injury

Frontiers in pharmacology, 2019-09, Vol.10, p.1093

2019

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The role of microRNAs in liver injury at the crossroad between hepatic cell death and regeneration

Biochemical and biophysical research communications, 2017-01, Vol.482 (3), p.399-407

2017

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Computational Methods for the Pharmacogenetic Interpretation of Next Generation Sequencing Data

Frontiers in pharmacology, 2018-12, Vol.9, p.1437-1437

2018

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In vitro and ex vivo modeling of enteric bacterial infections

Gut microbes, 2023, Vol.15 (1), p.2158034-2158034

2023

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Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation

Hepatology (Baltimore, Md.), 2016-11, Vol.64 (5), p.1743-1756

2016

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Intraocular liver spheroids for non-invasive high-resolution in vivo monitoring of liver cell function

Nature communications, 2024-01, Vol.15 (1), p.767-767, Article 767

2024

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Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three‐Dimensional Spheroid Cultures of Primary Human Hepatocytes

Clinical pharmacology and therapeutics, 2020-10, Vol.108 (4), p.844-855

2020

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Global genetic diversity of human apolipoproteins and effects on cardiovascular disease risk [S]

Journal of lipid research, 2018-10, Vol.59 (10), p.1987-2000

2018

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Rare genetic variant burden in DPYD predicts severe fluoropyrimidine-related toxicity risk

Biomedicine & pharmacotherapy, 2022-10, Vol.154, p.113644-113644, Article 113644

2022

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The Importance of Patient-Specific Factors for Hepatic Drug Response and Toxicity

Genetic variation in the human cytochrome P450 supergene family

Novel genetic and epigenetic factors of importance for inter-individual differences in drug disposition, response and toxicity

3D human liver spheroids for translational pharmacology and toxicology

Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions

Towards more accurate pharmacogenomic variant effect predictions

Human hepatic 3D spheroids as a model for steatosis and insulin resistance

Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation

Scaling of embryonic patterning based on phase―gradient encoding

Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long‐term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics

In vitro and ex vivo models of adipocytes

How to Consider Rare Genetic Variants in Personalized Drug Therapy

Human soluble ACE2 improves the effect of remdesivir in SARS‐CoV‐2 infection

Can CYP Inhibition Overcome Chemotherapy Resistance?

Development of the PGx‐Passport: A Panel of Actionable Germline Genetic Variants for Pre‐Emptive Pharmacogenetic Testing

Comprehensive overview of the pharmacogenetic diversity in Ashkenazi Jews

Comprehensive Evaluation of Organotypic and Microphysiological Liver Models for Prediction of Drug-Induced Liver Injury

The role of microRNAs in liver injury at the crossroad between hepatic cell death and regeneration

Computational Methods for the Pharmacogenetic Interpretation of Next Generation Sequencing Data

In vitro and ex vivo modeling of enteric bacterial infections

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation

Intraocular liver spheroids for non-invasive high-resolution in vivo monitoring of liver cell function

Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three‐Dimensional Spheroid Cultures of Primary Human Hepatocytes

Global genetic diversity of human apolipoproteins and effects on cardiovascular disease risk [S]

Rare genetic variant burden in DPYD predicts severe fluoropyrimidine-related toxicity risk

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