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Intestinal and hepatic biotransformation of pyrrolizidine alkaloid N-oxides to toxic pyrrolizidine alkaloids

Archives of toxicology, 2019-08, Vol.93 (8), p.2197-2209

2019

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Acetylation of putative arylamine and alkylaniline carcinogens in immortalized human fibroblasts transfected with rapid and slow acetylator N-acetyltransferase 2 haplotypes

Archives of toxicology, 2021-01, Vol.95 (1), p.311-319

2021

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Identification and characterization of potent, selective, and efficacious inhibitors of human arylamine N-acetyltransferase 1

Archives of toxicology, 2022-02, Vol.96 (2), p.511-524

2022

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Effects of dose and human N-acetyltransferase 1 genetic polymorphism in benzidine metabolism and genotoxicity

Archives of toxicology, 2023-06, Vol.97 (6), p.1765-1772

2023

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Differences in β-naphthylamine metabolism and toxicity in Chinese hamster ovary cell lines transfected with human CYP1A2 and NAT24, NAT25B or NAT27B N-acetyltransferase 2 haplotypes

Archives of toxicology, 2022-11, Vol.96 (11), p.2999-3012

2022

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Genetic heterogeneity among slow acetylator N-acetyltransferase 2 phenotypes in cryopreserved human hepatocytes

Archives of toxicology, 2017-07, Vol.91 (7), p.2655-2661

2017

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The effect of the rs1799931 G857A (G286E) polymorphism on N-acetyltransferase 2-mediated carcinogen metabolism and genotoxicity differs with heterocyclic amine exposure

Archives of toxicology, 2023-10, Vol.97 (10), p.2697-2705

2023

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Rabbit N-acetyltransferase 2 genotyping method to investigate role of acetylation polymorphism on N- and O-acetylation of aromatic and heterocyclic amine carcinogens

Archives of toxicology, 2017-09, Vol.91 (9), p.3185-3188

2017

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Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose

Archives of toxicology, 2022-02, Vol.96 (2), p.453-465

2022

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Investigations on detoxification mechanisms of novel para-phenylenediamine analogues through N-acetyltransferase 1 (NAT-1)

Archives of toxicology, 2022, Vol.96 (1), p.153-165

2022

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N-Acetyl-l-cysteine and aminooxyacetic acid differentially modulate trichloroethylene reproductive toxicity via metabolism in Wistar rats

Archives of toxicology, 2021-04, Vol.95 (4), p.1303-1321

2021

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First evidence of pyrrolizidine alkaloid N-oxide-induced hepatic sinusoidal obstruction syndrome in humans

Archives of toxicology, 2017-12, Vol.91 (12), p.3913-3925

2017

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Effects of arsenic exposure on d-serine metabolism in the hippocampus of offspring mice at different developmental stages

Archives of toxicology, 2020, Vol.94 (1), p.77-87

2020

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Role of the human N-acetyltransferase 2 genetic polymorphism in metabolism and genotoxicity of 4, 4′-methylenedianiline

Archives of toxicology, 2019-08, Vol.93 (8), p.2237-2246

2019

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Key factors of susceptibility to anti-tuberculosis drug-induced hepatotoxicity

Archives of toxicology, 2015-06, Vol.89 (6), p.883-897

2015

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The essential role of CYP2E1 in metabolism and hepatotoxicity of N,N-dimethylformamide using a novel Cyp2e1 knockout mouse model and a population study

Archives of toxicology, 2019-11, Vol.93 (11), p.3169-3181

2019

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Determination of NAT2 acetylation status in the Greenlandic population

Archives of toxicology, 2016-04, Vol.90 (4), p.883-889

2016

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The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment

Archives of toxicology, 2022-05, Vol.96 (5), p.1297-1352

2022

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Metabolism-mediated cytotoxicity and genotoxicity of pyrrolizidine alkaloids

Archives of toxicology, 2021-06, Vol.95 (6), p.1917-1942

2021

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High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing

Archives of toxicology, 2023-04, Vol.97 (4), p.1163-1175

2023

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N-Acetyltransferase 2: ultra-slow acetylators enter the stage

Archives of toxicology, 2015-12, Vol.89 (12), p.2445-2447

2015

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Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models

Archives of toxicology, 2023-10, Vol.97 (10), p.2785-2798

2023

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Role of human sulfotransferase 1A1 and N-acetyltransferase 2 in the metabolic activation of 16 heterocyclic amines and related heterocyclics to genotoxicants in recombinant V79 cells

Archives of toxicology, 2017-09, Vol.91 (9), p.3175-3184

2017

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Use of HuH6 and other human-derived hepatoma lines for the detection of genotoxins: a new hope for laboratory animals?

Archives of toxicology, 2018-02, Vol.92 (2), p.921-934

2018

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Intestinal and hepatic biotransformation of pyrrolizidine alkaloid N-oxides to toxic pyrrolizidine alkaloids

Acetylation of putative arylamine and alkylaniline carcinogens in immortalized human fibroblasts transfected with rapid and slow acetylator N-acetyltransferase 2 haplotypes

Identification and characterization of potent, selective, and efficacious inhibitors of human arylamine N-acetyltransferase 1

Effects of dose and human N-acetyltransferase 1 genetic polymorphism in benzidine metabolism and genotoxicity

Differences in β-naphthylamine metabolism and toxicity in Chinese hamster ovary cell lines transfected with human CYP1A2 and NAT24, NAT25B or NAT27B N-acetyltransferase 2 haplotypes

Genetic heterogeneity among slow acetylator N-acetyltransferase 2 phenotypes in cryopreserved human hepatocytes

The effect of the rs1799931 G857A (G286E) polymorphism on N-acetyltransferase 2-mediated carcinogen metabolism and genotoxicity differs with heterocyclic amine exposure

Rabbit N-acetyltransferase 2 genotyping method to investigate role of acetylation polymorphism on N- and O-acetylation of aromatic and heterocyclic amine carcinogens

Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose

Investigations on detoxification mechanisms of novel para-phenylenediamine analogues through N-acetyltransferase 1 (NAT-1)

N-Acetyl-l-cysteine and aminooxyacetic acid differentially modulate trichloroethylene reproductive toxicity via metabolism in Wistar rats

First evidence of pyrrolizidine alkaloid N-oxide-induced hepatic sinusoidal obstruction syndrome in humans

Effects of arsenic exposure on d-serine metabolism in the hippocampus of offspring mice at different developmental stages

Role of the human N-acetyltransferase 2 genetic polymorphism in metabolism and genotoxicity of 4, 4′-methylenedianiline

Key factors of susceptibility to anti-tuberculosis drug-induced hepatotoxicity

The essential role of CYP2E1 in metabolism and hepatotoxicity of N,N-dimethylformamide using a novel Cyp2e1 knockout mouse model and a population study

Determination of NAT2 acetylation status in the Greenlandic population

The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment

Metabolism-mediated cytotoxicity and genotoxicity of pyrrolizidine alkaloids

High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing

N-Acetyltransferase 2: ultra-slow acetylators enter the stage

Salivary nitrate/nitrite and acetaldehyde in humans: potential combination effects in the upper gastrointestinal tract and possible consequences for the in vivo formation of N-nitroso compounds—a hypothesis

Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models

Role of human sulfotransferase 1A1 and N-acetyltransferase 2 in the metabolic activation of 16 heterocyclic amines and related heterocyclics to genotoxicants in recombinant V79 cells

Use of HuH6 and other human-derived hepatoma lines for the detection of genotoxins: a new hope for laboratory animals?

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