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Citral inhibits the nociception in the rat formalin test: effect of metformin and blockers of opioid receptor and the NO-cGMP-K + channel pathway

Canadian journal of physiology and pharmacology, 2022-04, Vol.100 (4), p.306-313

2022

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VU6036720: The First Potent and Selective In Vitro Inhibitor of Heteromeric Kir4.1/5.1 Inward Rectifier Potassium Channels

Molecular pharmacology, 2022-05, Vol.101 (5), p.357-370

2022

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XE991 and Linopirdine Are State-Dependent Inhibitors for Kv7/KCNQ Channels that Favor Activated Single Subunits

The Journal of pharmacology and experimental therapeutics, 2017-07, Vol.362 (1), p.177-185

2017

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Pharmacological and molecular docking studies reveal that glibenclamide competitively inhibits diazoxide-induced mitochondrial ATP-sensitive potassium channel activation and pharmacological preconditioning

European journal of pharmacology, 2021-10, Vol.908, p.174379, Article 174379

2021

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A bifunctional sea anemone peptide with Kunitz type protease and potassium channel inhibiting properties

Biochemical pharmacology, 2011-07, Vol.82 (1), p.81-90

2011

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Defensins, a novel type of animal toxin-like potassium channel inhibitor

Toxicon (Oxford), 2019-01, Vol.157, p.101-105

2019

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Studies of Conorfamide-Sr3 on Human Voltage-Gated Kv1 Potassium Channel Subtypes

Marine drugs, 2020-08, Vol.18 (8), p.425

2020

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Understanding and improving photo‐control of ion channels in nociceptors with azobenzene photo‐switches

British journal of pharmacology, 2018-06, Vol.175 (12), p.2296-2311

2018

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A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias

The Journal of pharmacology and experimental therapeutics, 2013-01, Vol.344 (1), p.23-32

2013

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Relaxation effect of narirutin on rat mesenteric arteries via nitric oxide release and activation of voltage-gated potassium channels

European journal of pharmacology, 2021-08, Vol.905, p.174190-174190, Article 174190

2021

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Optimized J to T peak and T peak to T end measurements in nonclinical species administered moxifloxacin and amiodarone

Journal of pharmacological and toxicological methods, 2024-07, Vol.128, p.107527, Article 107527

2024

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Levosimendan Relaxes Thoracic Aortic Smooth Muscle in Mice by Inhibiting PKC and Activating Inwardly Rectifying Potassium Channels

Journal of cardiovascular pharmacology, 2024-05, Vol.83 (5), p.474-481

2024

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PAP-1 ameliorates DSS-induced colitis with involvement of NLRP3 inflammasome pathway

International immunopharmacology, 2019-10, Vol.75, p.105776-105776, Article 105776

2019

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Discovery of (3-(4-(2-Oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone (AZD1979), a Melanin Concentrating Hormone Receptor 1 (MCHr1) Antagonist with Favorable Physicochemical Properties

Journal of medicinal chemistry, 2016-03, Vol.59 (6), p.2497-2511

2016

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Molecular charge associated with antiarrhythmic actions in a series of amino-2-cyclohexyl ester derivatives

European journal of pharmacology, 2019-02, Vol.844, p.241-252

2019

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Selective I Kur Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5‑[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide

Journal of medicinal chemistry, 2017-05, Vol.60 (9), p.3795-3803

2017

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Involvement of Potassium Channels and Calcium-Independent Mechanisms in Hydrogen Sulfide-Induced Relaxation of Rat Mesenteric Small Arteries

The Journal of pharmacology and experimental therapeutics, 2016-01, Vol.356 (1), p.53-63

2016

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Chronic heart failure increases negative chronotropic effects of adenosine in canine sinoatrial cells via A1R stimulation and GIRK-mediated I Kado

Life sciences (1973), 2020-01, Vol.240, p.117068

2020

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The cardioprotective effect of naringenin against ischemia-reperfusion injury through activation of ATP-sensitive potassium channel in rat

Canadian journal of physiology and pharmacology, 2016-09, Vol.94 (9), p.973-978

2016

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Role of the NO-cGMP-K + channels pathway in the peripheral antinociception induced by α-bisabolol

Canadian journal of physiology and pharmacology, 2021-10, Vol.99 (10), p.1048-1056

2021

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Myrsinane, Premyrsinane, and Cyclomyrsinane Diterpenes from Euphorbia falcata as Potassium Ion Channel Inhibitors with Selective G Protein-Activated Inwardly Rectifying Ion Channel (GIRK) Blocking Effects

Journal of natural products (Washington, D.C.), 2016-08, Vol.79 (8), p.1990-2004

2016

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Vascular KCNQ potassium channels as novel targets for the control of mesenteric artery constriction by vasopressin, based on studies in single cells, pressurized arteries, and in vivo measurements of mesenteric vascular resistance

The Journal of pharmacology and experimental therapeutics, 2008-05, Vol.325 (2), p.475-483

2008

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Geraniol Blocks Calcium and Potassium Channels in the Mammalian Myocardium: Useful Effects to Treat Arrhythmias

Basic & clinical pharmacology & toxicology, 2014-12, Vol.115 (6), p.534-544

2014

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Molecular basis involved in the blocking effect of antidepressant metergoline on C-type inactivation of Kv1.4 channel

Neuropharmacology, 2019-03, Vol.146, p.65-73

2019

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Inhibition of voltage-gated potassium channels mediates uncarboxylated osteocalcin-regulated insulin secretion in rat pancreatic β cells

European journal of pharmacology, 2016-04, Vol.777, p.41-48

2016

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Citral inhibits the nociception in the rat formalin test: effect of metformin and blockers of opioid receptor and the NO-cGMP-K + channel pathway

VU6036720: The First Potent and Selective In Vitro Inhibitor of Heteromeric Kir4.1/5.1 Inward Rectifier Potassium Channels

XE991 and Linopirdine Are State-Dependent Inhibitors for Kv7/KCNQ Channels that Favor Activated Single Subunits

Pharmacological and molecular docking studies reveal that glibenclamide competitively inhibits diazoxide-induced mitochondrial ATP-sensitive potassium channel activation and pharmacological preconditioning

A bifunctional sea anemone peptide with Kunitz type protease and potassium channel inhibiting properties

Defensins, a novel type of animal toxin-like potassium channel inhibitor

Studies of Conorfamide-Sr3 on Human Voltage-Gated Kv1 Potassium Channel Subtypes

Understanding and improving photo‐control of ion channels in nociceptors with azobenzene photo‐switches

A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias

Relaxation effect of narirutin on rat mesenteric arteries via nitric oxide release and activation of voltage-gated potassium channels

Optimized J to T peak and T peak to T end measurements in nonclinical species administered moxifloxacin and amiodarone

Levosimendan Relaxes Thoracic Aortic Smooth Muscle in Mice by Inhibiting PKC and Activating Inwardly Rectifying Potassium Channels

PAP-1 ameliorates DSS-induced colitis with involvement of NLRP3 inflammasome pathway

Discovery of (3-(4-(2-Oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone (AZD1979), a Melanin Concentrating Hormone Receptor 1 (MCHr1) Antagonist with Favorable Physicochemical Properties

Molecular charge associated with antiarrhythmic actions in a series of amino-2-cyclohexyl ester derivatives

Selective I Kur Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5‑[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide

Involvement of Potassium Channels and Calcium-Independent Mechanisms in Hydrogen Sulfide-Induced Relaxation of Rat Mesenteric Small Arteries

Chronic heart failure increases negative chronotropic effects of adenosine in canine sinoatrial cells via A1R stimulation and GIRK-mediated I Kado

The cardioprotective effect of naringenin against ischemia-reperfusion injury through activation of ATP-sensitive potassium channel in rat

Role of the NO-cGMP-K + channels pathway in the peripheral antinociception induced by α-bisabolol

Myrsinane, Premyrsinane, and Cyclomyrsinane Diterpenes from Euphorbia falcata as Potassium Ion Channel Inhibitors with Selective G Protein-Activated Inwardly Rectifying Ion Channel (GIRK) Blocking Effects

Vascular KCNQ potassium channels as novel targets for the control of mesenteric artery constriction by vasopressin, based on studies in single cells, pressurized arteries, and in vivo measurements of mesenteric vascular resistance

Geraniol Blocks Calcium and Potassium Channels in the Mammalian Myocardium: Useful Effects to Treat Arrhythmias

Molecular basis involved in the blocking effect of antidepressant metergoline on C-type inactivation of Kv1.4 channel

Inhibition of voltage-gated potassium channels mediates uncarboxylated osteocalcin-regulated insulin secretion in rat pancreatic β cells

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