Details

Autor(en) / Beteiligte

• Ceccarelli, Michele
• Salama, Sofie R.
• Manyam, Ganiraju
• Zoppoli, Pietro
• Grifford, Mia
• Rao, Arvind
• Lau, Ching C.
• Huse, Jason
• Zheng, Siyuan
• Hess, Kenneth
• Rao, Ganesh
• Beroukhim, Rameen
• Akbani, Rehan
• Wrensch, Margaret
• Haussler, David
• Aldape, Kenneth D.
• Anjum, Samreen
• Balu, Saianand
• Barnett, Gene
• Black, Keith L.
• Bristow, Christopher A.
• Chen, Qing-Rong
• Cho, Juok
• Chuah, Eric
• Chudamani, Sudha
• Cohen, Mark L.
• Couce, Marta
• Davidsen, Tanja
• Davis, Amy
• Elder, J. Bradley
• Eschbacher, Jennifer M.
• Fehrenbach, Ashley
• Ferguson, Martin
• Fuller, Gregory
• Fulop, Jordonna
• Garofano, Luciano
• Gastier-Foster, Julie M.
• Gehlenborg, Nils
• Gerken, Mark
• Gibson, William J.
• Hadjipanayis, Angela
• Hayes, D. Neil
• Hilty, Joe
• Hoyle, Alan P.
• Jones, Corbin D.
• Jones, Steven J.M.
• Ju, Zhenlin
• Kastl, Alison
• Kendler, Ady
• Kucherlapati, Raju
• Lichtenberg, Tara M.
• Lin, Pei
• Ljubimova, Julia Y.
• Lu, Yiling
• Ma, Yussanne
• Maglinte, Dennis T.
• Marra, Marco A.
• Meng, Shaowu
• Miller, C. Ryan
• Mills, Gordon B.
• Mose, Lisle E.
• Naska, Theresa
• Noble, Michael S.
• Noss, Ardene
• Palmer, Cheryl
• Parfenov, Michael
• Parker, Joel S.
• Perou, Charles M.
• Pihl, Todd
• Protopopov, Alexei
• Ramirez, Nilsa C.
• Saksena, Gordon
• Schein, Jacqueline E.
• Shen, Hui
• Shi, Yan
• Shimmel, Kristen
• Sicotte, Hugues
• Sifri, Suzanne
• Silva, Tiago
• Singh, Rosy
• Song, Xingzhi
• Souza, Camila
• Sun, Huandong
• Sun, Charlie
• Tang, Jiabin
• Trevisan, Felipe Amstalden
• Van Den Berg, David J.
• Voet, Doug
• Wang, Zhining
• Weinstein, John N.
• Weisenberger, Daniel J.
• Wilkerson, Matthew D.
• Williams, Felicia
• Wise, Lisa
• Xu, Andrew W.
• Yang, Lixing
• Zack, Travis I.
• Zhang, Jianhua
• Zhang, Wei
• Zmuda, Erik

Titel

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma

Ist Teil von

• Cell, 2016-01, Vol.164 (3), p.550-563

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• Therapy development for adult diffuse glioma is hindered by incomplete knowledge of somatic glioma driving alterations and suboptimal disease classification. We defined the complete set of genes associated with 1,122 diffuse grade II-III-IV gliomas from The Cancer Genome Atlas and used molecular profiles to improve disease classification, identify molecular correlations, and provide insights into the progression from low- to high-grade disease. Whole-genome sequencing data analysis determined that ATRX but not TERT promoter mutations are associated with increased telomere length. Recent advances in glioma classification based on IDH mutation and 1p/19q co-deletion status were recapitulated through analysis of DNA methylation profiles, which identified clinically relevant molecular subsets. A subtype of IDH mutant glioma was associated with DNA demethylation and poor outcome; a group of IDH-wild-type diffuse glioma showed molecular similarity to pilocytic astrocytoma and relatively favorable survival. Understanding of cohesive disease groups may aid improved clinical outcomes. [Display omitted] •Comprehensive molecular profiling of 1,122 adult diffuse grade II, III, and IV gliomas•Telomere length and telomere maintenance defined by somatic alterations•DNA methylation profiling reveals subtypes of IDH mutant and IDH-wild-type glioma•Integrated molecular analysis of progression from low-grade to high-grade disease Integration of a large sample size of glioma tumors with multidimensional ‘omic characterization and clinical annotation provides insights into molecular classification, telomere maintenance mechanisms, progression from low to high grade disease, driver mutations, and therapeutic options.