Details

Autor(en) / Beteiligte

• Lowes, Michelle A.
• Chamian, Francesca
• Maria Veronica Abello
• Judilyn Fuentes-Duculan
• Lin, Shao-Lee
• Nussbaum, Rachel
• Novitskaya, Inna
• Henrietta Carbonaro
• Cardinale, Irma
• Kikuchi, Toyoko
• Gilleaudeau, Patricia
• Sullivan-Whalen, Mary
• Wittkowski, Knut M.
• Kim Papp
• Marvin Garovoy
• Wolfgang Dummer
• Steinman, Ralph M.
• Krueger, James G.

Titel

Increase in TNF-α and Inducible Nitric Oxide Synthase-Expressing Dendritic Cells in Psoriasis and Reduction with Efalizumab (Anti-CD11a)

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2005-12, Vol.102 (52), p.19057-19062

Ort / Verlag

United States: National Academy of Sciences

Erscheinungsjahr

2005

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• We find that CD11c+cells with many markers of dendritic cells (DCs) are a major cell type in the skin lesions of psoriasis. These CD11c+cells, which are evident in both epidermis and dermis, are the sites for the expression of two mediators of inflammation, inducible nitric oxide synthase (iNOS) and$TNF-\alpha$in diseased skin. These cells express HLA-DR, CD40, and CD86, lack the Langerin and CD14 markers of Langerhans cells and monocytes, respectively, and to a significant extent express the DC maturation markers DC-LAMP and CD83. Treatment of psoriasis with efalizumab (anti-CD11a, Raptiva) strongly reduces infiltration by these DCs in patients responding to this agent. Disease activity after therapy was more related to DC infiltrates and iNOS mRNA levels than T cell infiltrates, and CD11c+cells responded more quickly to therapy than epidermal keratinocytes. Our results suggest that a type of DC, which resembles murine "Tip-DCs" that can accumulate during infection, has proinflammatory effects in psoriasis through nitric oxide and$TNF-\alpha$production, and can be an important target for suppressive therapies.