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Immunohistochemical Analysis for Neural Markers of the Lateral Retinaculum in Patients with Isolated Symptomatic Patellofemoral Malalignment
Ist Teil von
The American journal of sports medicine, 2000-09, Vol.28 (5), p.725-731
Ort / Verlag
Los Angeles, CA: American Orthopaedic Society for Sports Medicine
Erscheinungsjahr
2000
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
We evaluated 13 lateral retinacula excised at the time of Insall proximal realignments or isolated lateral retinacular releases
performed in patients with isolated symptomatic patellofemoral malalignment recalcitrant to nonoperative treatment. Evaluation
was performed by means of conventional histologic and immunohistochemical analysis for neural markers (S-100 protein, neurofilament
protein, substance P, and neural growth factor). The observations reported here provide a neuroanatomic basis for anterior
knee pain syndrome in active young patients with isolated symptomatic patellofemoral malalignment and support the clinical
observation that the lateral retinaculum may have a key role in the origin of this pain as a result of increased neural growth
factor production, which induces proliferation of nociceptive axons, mainly in a perivascular location.