Details

Autor(en) / Beteiligte

• Sheridan, Thomas
• Yayla, Hatice G.
• Lian, Yajing
• Genovino, Julien
• Monck, Nat
• Burton, Jonathan W.

Titel

Organophotochemical SNAr Reactions of Mildly Electron‐Poor Fluoroarenes

Ist Teil von

• European journal of organic chemistry, 2020-05, Vol.2020 (18), p.2766-2770

Ort / Verlag

Weinheim: Wiley Subscription Services, Inc

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• C–F functionalization of arenes with a range of alcohol and pyrazole nucleophiles has been achieved without the need for metal catalysts or highly electron‐poor substrates. Treatment of fluoroarenes with alcohols or pyrazoles and DDQ under irradiation by blue LED light provides the corresponding substituted products. The procedure is complementary to classical SNAr chemistry which generally requires basic reaction conditions and high temperatures, and provides products under non‐basic conditions at ≈ 40 °C. C–F functionalization of arenes with a range of alcohol and pyrazole nucleophiles has been achieved without the need for metal catalysts or highly electron‐poor substrates. Treatment of fluoroarenes with alcohols or pyrazoles and DDQ under irradiation by blue LED light provides the corresponding substituted products.