Nature communications, 2020-02, Vol.11 (1), p.1091-1091, Article 1091
2020
Details
- Autor(en) / Beteiligte
- Titel
- Mass cytometry reveals cellular fingerprint associated with IgE+ peanut tolerance and allergy in early life
- Ist Teil von
- Nature communications, 2020-02, Vol.11 (1), p.1091-1091, Article 1091
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- Alma/SFX Local Collection
- Beschreibungen/Notizen
- IgE-mediated peanut allergic is common, often serious, and usually lifelong. Not all individuals who produce peanut-specific IgE will react upon consumption of peanut and can eat the food without adverse reactions, known as sensitized tolerance. Here, we employ high-dimensional mass cytometry to define the circulating immune cell signatures associated with sensitized tolerance and clinical allergy to peanut in the first year of life. Key features of clinical peanut allergic are increased frequency of activated B cells (CD19 HLADR ), overproduction of TNFα and increased frequency of peanut-specific memory CD4 T cells. Infants with sensitized tolerance display reduced frequency but hyper-responsive naive CD4 T cells and an increased frequency of plasmacytoid dendritic cells. This work demonstrates the utility and power of high-dimensional mass cytometry analysis to interrogate the cellular interactions that are associated with allergic sensitization and clinical food allergy in the first year of life.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2041-1723eISSN: 2041-1723DOI: 10.1038/s41467-020-14919-4Titel-ID: cdi_doaj_primary_oai_doaj_org_article_966c4c38a8dd4e93886f0419ac4fec6a
- Format
- –
- Schlagworte
- Allergens - immunology, Arachis - immunology, B-Lymphocytes - immunology, B-Lymphocytes - metabolism, CD4 antigen, CD4-Positive T-Lymphocytes - immunology, CD4-Positive T-Lymphocytes - metabolism, Cells, Cultured, Cytometry, Dendritic cells, Dendritic Cells - immunology, Dendritic Cells - metabolism, Dimensional analysis, Dimensional tolerances, Female, Food, Food allergies, Humans, Immune system, Immune Tolerance - immunology, Immunoglobulin E, Immunoglobulin E - immunology, Immunoglobulin E - metabolism, Immunologic Memory, Immunological memory, Immunological tolerance, Infant, Infants, Lymphocytes, Lymphocytes B, Lymphocytes T, Male, Mass Spectrometry - methods, Memory cells, Nuts, Peanut Hypersensitivity - diagnosis, Peanut Hypersensitivity - immunology, Peanuts, Primary Cell Culture, Tumor Necrosis Factor-alpha - immunology, Tumor Necrosis Factor-alpha - metabolism, Tumor necrosis factor-α